-
1
-
-
0036800592
-
A genetic view of iron homeostasis
-
Andrews NC. A genetic view of iron homeostasis. Semin Hematol 2002; 39:227-34.
-
(2002)
Semin Hematol
, vol.39
, pp. 227-234
-
-
Andrews, N.C.1
-
2
-
-
0041672570
-
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
-
Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003; 102:783-8.
-
(2003)
Blood
, vol.102
, pp. 783-788
-
-
Ganz, T.1
-
3
-
-
20844460608
-
Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine
-
Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 2004; 89: 1187-93.
-
(2004)
Haematologica
, vol.89
, pp. 1187-1193
-
-
Borgna-Pignatti, C.1
Rugolotto, S.2
De Stefano, P.3
Zhao, H.4
Cappellini, M.D.5
Del Vecchio, G.C.6
-
4
-
-
33749991316
-
Phase II clinical evaluation of deferasirox (Exjade, ICL670) a once-daily oral chelatgin agent, in paediatric patients with β-thalassaemia major
-
Galanello R, Piga A, Forni GL, Bertrand Y, Foschini ML, Bordone E, et al. Phase II clinical evaluation of deferasirox (Exjade, ICL670) a once-daily oral chelatgin agent, in paediatric patients with β-thalassaemia major. Haematologica 2006; 91:XXX.
-
(2006)
Haematologica
, vol.91
-
-
Galanello, R.1
Piga, A.2
Forni, G.L.3
Bertrand, Y.4
Foschini, M.L.5
Bordone, E.6
-
7
-
-
0141705304
-
Labile plasma iron in iron overload: Redox activity and sucsceptibility to chelation
-
Esposito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, Cabantchik ZI. Labile plasma iron in iron overload: redox activity and sucsceptibility to chelation Blood 2003;102:2670-7.
-
(2003)
Blood
, vol.102
, pp. 2670-2677
-
-
Esposito, B.P.1
Breuer, W.2
Sirankapracha, P.3
Pootrakul, P.4
Hershko, C.5
Cabantchik, Z.I.6
-
8
-
-
15744397395
-
Monitoring and treatment of iron overload: State of the art and new approaches
-
Porter JB. Monitoring and treatment of iron overload: state of the art and new approaches. Semin Hematol 2005; 42: S14-8.
-
(2005)
Semin Hematol
, vol.42
-
-
Porter, J.B.1
-
9
-
-
11244355277
-
Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
-
St. Pierre TG, Clark PR, Chua-anusom W, Fleming AJ, Jeffrey GP, Olynyk JK, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105: 855-61.
-
(2005)
Blood
, vol.105
, pp. 855-861
-
-
St. Pierre, T.G.1
Clark, P.R.2
Chua-anusom, W.3
Fleming, A.J.4
Jeffrey, G.P.5
Olynyk, J.K.6
-
10
-
-
0028059813
-
Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major
-
Brittenham GM, Griffith PM, Nienhuis AW, McLaren CE, Young NS, Tucker EE, et al. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med 1994; 331:567-73.
-
(1994)
N Engl J Med
, vol.331
, pp. 567-573
-
-
Brittenham, G.M.1
Griffith, P.M.2
Nienhuis, A.W.3
McLaren, C.E.4
Young, N.S.5
Tucker, E.E.6
-
11
-
-
0028086414
-
Survival in medically treated patients with homozygous β-thalassemia
-
Olivieri NF, Nathan DG, MacMillan JH, Wayne AS, Liu PP, McGee A, et al. Survival in medically treated patients with homozygous β-thalassemia. N Engl J Med 1994;331:574-8.
-
(1994)
N Engl J Med
, vol.331
, pp. 574-578
-
-
Olivieri, N.F.1
Nathan, D.G.2
MacMillan, J.H.3
Wayne, A.S.4
Liu, P.P.5
McGee, A.6
-
12
-
-
18044399191
-
Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload
-
Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 2001;22:2171-9.
-
(2001)
Eur Heart J
, vol.22
, pp. 2171-2179
-
-
Anderson, L.J.1
Holden, S.2
Davis, B.3
Prescott, E.4
Charrier, C.C.5
Bunce, N.H.6
-
13
-
-
7944230624
-
Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: A prospective study using T2* cardiovascular magnetic resonance
-
Anderson LJ, Westwood MA, Holden S, Davis B, Prescott E, Wonke B, et al. Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance. Br J Haematol 2004;127: 348-55.
-
(2004)
Br J Haematol
, vol.127
, pp. 348-355
-
-
Anderson, L.J.1
Westwood, M.A.2
Holden, S.3
Davis, B.4
Prescott, E.5
Wonke, B.6
-
14
-
-
0034651775
-
Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk β-thalassemia
-
Davis BA, Porter JB. Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk β-thalassemia. Blood 2000;95:1229-36.
-
(2000)
Blood
, vol.95
, pp. 1229-1236
-
-
Davis, B.A.1
Porter, J.B.2
-
15
-
-
0038133426
-
Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation
-
Miskin H, Yaniv I, Berant M, Hershko C, Tamary H. Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation Eur J Haematol 2003; 70:398-403.
-
(2003)
Eur J Haematol
, vol.70
, pp. 398-403
-
-
Miskin, H.1
Yaniv, I.2
Berant, M.3
Hershko, C.4
Tamary, H.5
-
16
-
-
3042746877
-
Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
-
Davis BA, O'Sullivan C, Jarritt PH, Porter JB. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 2004;104:263-9.
-
(2004)
Blood
, vol.104
, pp. 263-269
-
-
Davis, B.A.1
O'Sullivan, C.2
Jarritt, P.H.3
Porter, J.B.4
-
17
-
-
0034631379
-
Survival in β-thalassaemia major in the UK: Data from the UK Thalassaemia Register
-
Modell B, Khan M, Darlison M: Survival in β-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 2000;355:2051-2.
-
(2000)
Lancet
, vol.355
, pp. 2051-2052
-
-
Modell, B.1
Khan, M.2
Darlison, M.3
-
18
-
-
3042758517
-
Complications of β-thalassemia major in North America
-
Cunningham MJ, Macklin EA, Neufeld EJ. Complications of β-thalassemia major in North America. Blood 2004; 104:34-9.
-
(2004)
Blood
, vol.104
, pp. 34-39
-
-
Cunningham, M.J.1
Macklin, E.A.2
Neufeld, E.J.3
-
19
-
-
0032887235
-
Deferiprone. A review of its clinical potential in iron overload in β-thalassaemia major and other transfusion-dependent diseases
-
Barman Balfour JA, Foster RH. Deferiprone. A review of its clinical potential in iron overload in β-thalassaemia major and other transfusion-dependent diseases. Drugs 1999;58: 553-78.
-
(1999)
Drugs
, vol.58
, pp. 553-578
-
-
Barman Balfour, J.A.1
Foster, R.H.2
-
20
-
-
0037630378
-
Role of deferiprone in chelation therapy for transfusional iron overload
-
Hoffbrand AV, Cohen A, Hershko C. Role of deferiprone in chelation therapy for transfusional iron overload. Blood 2003; 102:17-24.
-
(2003)
Blood
, vol.102
, pp. 17-24
-
-
Hoffbrand, A.V.1
Cohen, A.2
Hershko, C.3
-
21
-
-
0038187626
-
Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
-
Piga A, Gaglioti C, Fogliacco E, Tricta F. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica 2003;88:489-96.
-
(2003)
Haematologica
, vol.88
, pp. 489-496
-
-
Piga, A.1
Gaglioti, C.2
Fogliacco, E.3
Tricta, F.4
-
22
-
-
0037125595
-
Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia
-
Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennell DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in β-thalassaemia. Lancet 2002;360:516-20.
-
(2002)
Lancet
, vol.360
, pp. 516-520
-
-
Anderson, L.J.1
Wonke, B.2
Prescott, E.3
Holden, S.4
Walker, J.M.5
Pennell, D.J.6
-
23
-
-
33646387405
-
Randomized controlled trial of deferiprone or deferoxamine in β-thalassemia major patients with asymptomatic myocardial siderosis
-
Pennell DJ, Berdoukas V, Karagiorga M, Ladis V, Piga A, Aessopos A, et al. Randomized controlled trial of deferiprone or deferoxamine in β-thalassemia major patients with asymptomatic myocardial siderosis. Blood 2006;107: 3738-44.
-
(2006)
Blood
, vol.107
, pp. 3738-3744
-
-
Pennell, D.J.1
Berdoukas, V.2
Karagiorga, M.3
Ladis, V.4
Piga, A.5
Aessopos, A.6
-
24
-
-
27144560152
-
Combined therapy with deferiprone and desferrioxamine in thalassemia major
-
Origa R, Bina P, Agus A, Crobu G, Defraia E, Dessi C, et al. Combined therapy with deferiprone and desferrioxamine in thalassemia major. Haematologica 2005;90:1309-14.
-
(2005)
Haematologica
, vol.90
, pp. 1309-1314
-
-
Origa, R.1
Bina, P.2
Agus, A.3
Crobu, G.4
Defraia, E.5
Dessi, C.6
-
25
-
-
33646407268
-
Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
-
Borgna-Pignatti C, Cappellini MD, De Stefano P, Del Vecchio GC, Forni GL, Gamberini MR, et al Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood 2006;107:3733-7.
-
(2006)
Blood
, vol.107
, pp. 3733-3737
-
-
Borgna-Pignatti, C.1
Cappellini, M.D.2
De Stefano, P.3
Del Vecchio, G.C.4
Forni, G.L.5
Gamberini, M.R.6
-
26
-
-
33748807736
-
Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004
-
Telfer P, Coen PG, Christou S, Hadjigavriel M, Kolnakou A, Pangalou E, et al. Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004. Haematologica 2006;91:1187-92.
-
(2006)
Haematologica
, vol.91
, pp. 1187-1192
-
-
Telfer, P.1
Coen, P.G.2
Christou, S.3
Hadjigavriel, M.4
Kolnakou, A.5
Pangalou, E.6
-
27
-
-
33748783066
-
A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia
-
Galanello R, Kattamis A, Piga A, Fischer R, Leoni G, Ladis V, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica 2006;91:1241-3.
-
(2006)
Haematologica
, vol.91
, pp. 1241-1243
-
-
Galanello, R.1
Kattamis, A.2
Piga, A.3
Fischer, R.4
Leoni, G.5
Ladis, V.6
-
28
-
-
0038324389
-
Development of tridentate iron chelators from desferrithiocin to ICL670
-
Nick H, Acklin P, Lattmann R, Buehlmayer P, Hauffe S, Schupp J, et al. Development of tridentate iron chelators from desferrithiocin to ICL670. Curr Med Chem 2003; 10:1065-76.
-
(2003)
Curr Med Chem
, vol.10
, pp. 1065-1076
-
-
Nick, H.1
Acklin, P.2
Lattmann, R.3
Buehlmayer, P.4
Hauffe, S.5
Schupp, J.6
-
29
-
-
33750001927
-
Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
-
Epub ahead of print
-
Glickstein H, Ben El R, Link G, Breuer W, Konijn AM, Hershko C, et al. Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 2006;(Epub ahead of print).
-
(2006)
Blood
-
-
Glickstein, H.1
Ben El, R.2
Link, G.3
Breuer, W.4
Konijn, A.M.5
Hershko, C.6
-
30
-
-
0035865702
-
ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
-
Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 2001;97:1115-22.
-
(2001)
Blood
, vol.97
, pp. 1115-1122
-
-
Hershko, C.1
Konijn, A.M.2
Nick, H.P.3
Breuer, W.4
Cabantchik, Z.I.5
Link, G.6
-
31
-
-
0037906104
-
Safety, tolerability and pharmacolinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron-overload due to β-thalassemia
-
Galanello R, Piga A, Alberti D, Rouan MC, Bigler H, Sechaud R. Safety, tolerability and pharmacolinetics of ICL670, a new orally active iron-chelating agent in patients with transfusion-dependent iron-overload due to β-thalassemia. J Clin Pharmacol 2003;43:565-72.
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 565-572
-
-
Galanello, R.1
Piga, A.2
Alberti, D.3
Rouan, M.C.4
Bigler, H.5
Sechaud, R.6
-
32
-
-
10744230223
-
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
-
Nisbet-Brown E, Olivieri NT, Giardina PJ, Grady RW, Neufeld EJ, Sechaud R, et al. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2003;361:1597-602.
-
(2003)
Lancet
, vol.361
, pp. 1597-1602
-
-
Nisbet-Brown, E.1
Olivieri, N.T.2
Giardina, P.J.3
Grady, R.W.4
Neufeld, E.J.5
Sechaud, R.6
-
33
-
-
33646414765
-
A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia
-
Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia. Blood 2006; 107: 3455-62.
-
(2006)
Blood
, vol.107
, pp. 3455-3462
-
-
Cappellini, M.D.1
Cohen, A.2
Piga, A.3
Bejaoui, M.4
Perrotta, S.5
Agaoglu, L.6
-
34
-
-
33745774771
-
Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
-
Piga A, Galanello R, Forni GL et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica 2006;91:873-80.
-
(2006)
Haematologica
, vol.91
, pp. 873-880
-
-
Piga, A.1
Galanello, R.2
Forni, G.L.3
-
35
-
-
33646402757
-
Improved myocardial T2* in transfusion dependent anemias receiving ICL670 (Deferasirox)
-
abstract
-
Porter JB, Tanner MA, Pennell DJ, Eleftheriou P. Improved myocardial T2* in transfusion dependent anemias receiving ICL670 (Deferasirox) Blood 2005; 106:3600[abstract].
-
(2005)
Blood
, vol.106
, pp. 3600
-
-
Porter, J.B.1
Tanner, M.A.2
Pennell, D.J.3
Eleftheriou, P.4
|