Reversal of cardiac complications in thalassemia major by long-term intermittent daily intensive iron chelation

European Journal of Haematology

Volumn 70, Issue 6, 2003, Pages 398-403

  Miskin, H ^a   Yaniv, I ^a   Berant, M ^a,b   Hershko, C ^c   Tamary, Hannah ^a  

^a SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

Arrhythmia; Congestive heart failure; Intravenous deferoxamine; Iron overload; Thalassemia major

Indexed keywords

CHELATING AGENT; DEFEROXAMINE;

ADOLESCENT; ARTICLE; CARDIOTOXICITY; CHILD; CLINICAL ARTICLE; CONGESTIVE HEART FAILURE; CONTINUOUS INFUSION; DRUG EFFECT; DRUG INTERMITTENT THERAPY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; FERRITIN BLOOD LEVEL; HEART ARRHYTHMIA; HEART DISEASE; HUMAN; IRON CHELATION; IRON OVERLOAD; MALE; PRIORITY JOURNAL; SURVIVAL; THALASSEMIA MAJOR;

ADOLESCENT; ADULT; ARRHYTHMIA; CATHETERIZATION, CENTRAL VENOUS; CHELATION THERAPY; DEFEROXAMINE; FOLLOW-UP STUDIES; HEART DISEASES; HUMANS; IRON CHELATING AGENTS; RETROSPECTIVE STUDIES; STROKE VOLUME; THALASSEMIA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0038133426     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2003.00075.x     Document Type: Article

References (15)

1. WOLFE L, OLIVIERI N, SALLAN D, COLAN S, ROSE V, PROPPER R, FREEDMAN MH, NATHAN DG. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. N Engl J Med 1985;312:1600-1603.
2. ZURLO MG, DE STEFANO P, BORGNA-PIGNATTI C, DI PALMA A, PIGA A, MELEVENDI C, DI GREGORIO F, BURATTINI MG, TERZOLI S. Survival and causes of death in thalassemia major. Lancet 1989;8653:27-30.
3. BRITTENHAM GM, GRIFFITH PM, NIENHUIS AW, MCLAREN CE, YOUNG NS, TUCKER EE, ALLEN CJ, FARRELL DE, HARRIS JW. Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med 1994;331:567-573.
4. OLIVIERI NF, NATHAN DG, MACMILLAN JH, WAYNE AS, LIU ZP, MCGEE A, MARTIN M, KOREN G, COHEN AR. Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med 1994;331:574-578.
5. MODELL B, KHAN M, DARLISON M. Survival in beta thalassemia major in the United Kingdom: data from the U.K. Thalassemia Register. Lancet 2000;355:2051-2052.
6. MARCUS RE, DAVIES SC, BANTOCK HM, UNDERWOOD SR, WALTON S, HUEHNS ER. Desferrioxamine to improve cardiac function in iron-overloaded patients with thalassemia major. Lancet 1984;8373:392-393.
7. ALDOURI MA, WONKE B, HOFFBRAND AV, FLYNN DM, WARD SE, AGNEW JE, HILSON AJ. High incidence of cardiomyopathy in beta-thalassemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematol 1990;84:113-117.
8. COHEN AR, MARTIN M, SCHWARTZ E. Current treatment of Cooley's anemia. Intravenous chelation therapy. Ann N Y Acad Sci 1990;612:286-292.
9. TAMARY H, GOSHEN J, CARMI D, YANIV I, KAPLINSKY C, COHEN IJ, ZAIZOV R. Long-term intravenous deferoxamine treatment for noncompliant transfusion-dependent beta-thalassemia patients. Isr J of Med Sci 1994;30:658-664.
10. DAVIS BA, PORTER JB. Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia. Blood 2000;95:1229-1236.
11. ENGLE MA, ERLANDSON M, SMITH CH. Late cardiac complications ofchronic severe, refractory anemia with hemochromatosis. Circulation 1964;30:698-705.
12. OLIVIERI NF, SNIDER MA, NATHAN DG, GEE B, MUROFF A, MARTIN M, VICHINSKY EP, COHEN AR. Survival following the onset of iron-induced cardiac disease in thalassemia major. Blood 1995;86:250a.
13. KREMASTINOS DT, TSETSOS GA, TSIAPRAS DP, KARAVOLIAS GK, LADIS VA, KETTAMIS CA. Heart failure in beta thalassemia: a 5-year follow-up study. Am J Med 2001;111:349-354.
14. PORTER JB, ABEYSINGHE RD, MARSHALL L, HIDER RC, SINGH S. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood 1996;88:705-713.
15. DECKER MD, EDWARDS KM. Central venous catheter infections. Pediatr Clin North Am 1988;35:579-612.