Circulating Endothelial Cells in Cardiovascular Disease

Journal of the American College of Cardiology

Volumn 48, Issue 8, 2006, Pages 1538-1547

  Boos, Christopher J ^a   Lip, Gregory Y H ^a   Blann, Andrew D ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE HEART INFARCTION; BLOOD CELL; BONE MARROW; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL COUNT; CELL ISOLATION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CORONARY ARTERY DISEASE; DEATH; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ESSENTIAL HYPERTENSION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; IMMUNOMAGNETIC SEPARATION; INTERMITTENT CLAUDICATION; INTIMA; LIMB ISCHEMIA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STEM CELL; STROKE; UNSTABLE ANGINA PECTORIS;

CARDIOVASCULAR DISEASES; CELL COUNT; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS;

EID: 33749682424     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2006.02.078     Document Type: Review

References (103)

1. Murray C.J., and Lopez A.D. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 349 (1997) 1436-1442
2. De Backer G., Ambrosioni E., Borch-Johnsen K., et al., European Society of Cardiology, American Heart Association, American College of Cardiology. European guidelines on cardiovascular disease prevention in clinical practice. Atherosclerosis 173 (2004) 381-391
3. Goodacre S., Cross E., Arnold J., Angelini K., Capewell S., and Nicholl J. The health care burden of acute chest pain. Heart 91 (2005) 229-230
4. EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J 22 (2001) 554-572
5. Blann A.D. Assessment of endothelial dysfunction: focus on atherothrombotic disease. Pathophysiol Haemost Thromb 33 (2004) 256-261
6. Zeiher A.M., Drexler H., Saurbier B., and Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 92 (1993) 652-662
7. Anderson T.J., Uehata A., Gerhard M.D., et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26 (1995) 1235-1241
8. Boneu B., Abbal M., Plante J., and Bierme R. Factor VIII-complex and endothelial damage. Lancet i (1975) 1430
9. Blann A.D., Woywodt A., Bertolini F., et al. Circulating endothelial cells. Biomarker of vascular disease. Thromb Haemost 93 (2005) 228-235
10. Ruegg C., Yilmaz A., Bieler G., Bamat J., Chaubert P., and Lejeune F.J. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumour vasculature induced by TNF and IFN-gamma. Nat Med 4 (1998) 408-414
11. Re F., Zanetti A., Sironi M., et al. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 127 (1994) 537-546
12. Rafii S., Shapiro F., Rimarachin J., et al. Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion. Blood 84 (1994) 10-19
13. Boyer M., Townsend L.E., Vogel L.M., et al. Isolation of endothelial cells and their progenitor cells from human peripheral blood. J Vasc Surg 31 (2000) 181-189
14. Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275 (1997) 964-967
15. Hristov M., Erl W., and Weber P.C. Endothelial progenitor cells: mobilization, differentiation, and homing. Arterioscler Thromb Vasc Biol 23 (2003) 1185-1189
16. Bompais H., Chagraoui J., Canron X., et al. Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells. Blood 103 (2004) 2577-2584
17. George F., Brisson C., Poncelet P., et al. Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost 67 (1992) 147-153
18. George F., Poncelet P., Laurent J.C., et al. Cytofluorometric detection of human endothelial cells in whole blood using S-Endo 1 monoclonal antibody. J Immunol Methods 139 (1991) 65-75
19. Bardin N., Anfosso F., Masse J.M., et al. Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 98 (2001) 3677-3684
20. Anfosso F., Bardin N., Vivier E., Sabatier F., Sampol J., and Dignat-George F. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. J Biol Chem 276 (2001) 1564-1569
21. Woywodt A., Goldberg C., Scheer J., Regelsberger H., Haller H., and Haubitz M. An improved assay for enumeration of circulating endothelial cells. Ann Hematol 83 (2004) 491-494
22. Forgione M.A., Leopold J.A., and Loscalzo J. Roles of endothelial dysfunction in coronary artery disease. Curr Opin Cardiol 15 (2000) 409-415
23. Jambrik Z., Venneri L., Varga A., Rigo F., Borges A., and Picano E. Peripheral vascular endothelial function testing for the diagnosis of coronary artery disease. Am Heart J 148 (2004) 684-689
24. Brevetti G., Silvestro A., Schiano V., and Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 108 (2003) 2093-2098
25. Perticone F., Ceravolo R., Pujia A., et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104 (2001) 191-196
26. Schmieder R.E., Weihprecht H., Schobel H., et al. Is endothelial function of the radial artery altered in human essential hypertension?. Am J Hypertens 10 (1997) 323-331
27. Zvan B., Zaletel M., Pogacnik T., and Kiauta T. Testing of cerebral endothelium function with L-arginine after stroke. Int Angiol 21 (2002) 256-259
28. Landmesser U., Spiekermann S., Dikalov S., et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 106 (2002) 3073-3078
29. de Jong R.M., Blanksma P.K., Cornel J.H., et al. Endothelial dysfunction and reduced myocardial perfusion reserve in heart failure secondary to coronary artery disease. Am J Cardiol 91 (2003) 497-500
30. Marin F., Roldan V., Climent V.E., et al. Plasma von Willebrand factor, soluble thrombomodulin, and fibrin D-dimer concentrations in acute onset non-rheumatic atrial fibrillation. Heart 90 (2004) 1162-1166
31. Conway D.S., Pearce L.A., Chin B.S., Hart R.G., and Lip G.Y. Prognostic value of plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 994 patients with nonvalvular atrial fibrillation. Circulation 107 (2003) 3141-3145
32. Conway D.S., Pearce L.A., Chin B.S., Hart R.G., and Lip G.Y. Plasma von Willebrand factor and soluble P-selectin as indices of endothelial damage and platelet activation in 1321 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors. Circulation 106 (2002) 1962-1967
33. Dandona P., Chaudhuri A., and Aljada A. Endothelial dysfunction and hypertension in diabetes mellitus. Med Clin North Am 88 (2004) 911-931
34. Kimura Y., Matsumoto M., Miyauchi E., Deng Y.B., Iwai K., and Hattori H. Noninvasive detection of endothelial dysfunction in elderly with NIDDM by ultrasonography. Echocardiography 18 (2001) 559-564
35. Grefte A., van der Giessen M., van Son W., and The T.H. Circulating cytomegalovirus (CMV)-infected endothelial cells in patients with an active CMV infection. J Infect Dis 167 (1993) 270-277
36. Rajagopalan S., Somers E.C., Brook R.D., et al. Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity. Blood 103 (2004) 3677-3683
37. Chong A.Y., Blann A.D., Patel J., Freestone B., Hughes E., and Lip G.Y. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. Circulation 110 (2004) 1794-1798
38. Mancuso P., Calleri A., Cassi C., et al. Circulating endothelial cells as a novel marker of angiogenesis. Adv Exp Med Biol 522 (2003) 83-97
39. Makin A., Chung N.A.Y., Silverman S.H., Blann A., and Lip G.Y. Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Eur Heart J 25 (2004) 371-376
40. Butthep P., Rummavas S., Wisedpanichkij R., Jindadamrongwech S., Fucharoen S., and Bunyaratvej A. Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia. Am J Hematol 70 (2002) 100-106
41. Janssens D., Michiels C., Guillaume G., Cuisinier B., Louagie Y., and Remacle J. Increase in circulating endothelial cells in patients with primary chronic venous insufficiency: protective effect of Ginkor Fort in a randomized double-blind, placebo-controlled clinical trial. J Cardiovasc Pharmacol 33 (1999) 7-11
42. Dang A., Wang B., Li W., et al. Plasma endothelin-1 levels and circulating endothelial cells in patients with aortoarteritis. Hypertens Res 23 (2000) 541-544
43. Bull T.M., Golpon H., Hebbel R.P., et al. Circulating endothelial cells in pulmonary hypertension. Thromb Haemost 90 (2003) 698-703
44. Camoin-Jau L., Kone-Paut I., Chabrol B., Sampol J., and Dignat-George F. Circulating endothelial cells in Behcet's disease with cerebral thrombophlebitis. Thromb Haemost 83 (2000) 631-632
45. Mutunga M., Fulton B., Bullock R., et al. Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 163 (2001) 195-200
46. Furstenberger G., von Moos R., Senn H.J., and Boneberg E.M. Real-time PCR of CD146 mRNA in peripheral blood enables the relative quantification of circulating endothelial cells and is an indicator of angiogenesis. Br J Cancer 93 (2005) 793-798
47. Solovey A., Lin Y., Browne P., Choong S., Wayner E., and Hebbel R.P. Circulating activated endothelial cells in sickle cell anaemia. N Engl J Med 337 (1997) 1584-1590
48. Lefevre P., George F., Durand J.M., and Sampol J. Detection of circulating endothelial cells in thrombotic thrombocytopenic purpura. Thromb Haemost 69 (1993) 522
49. Drancourt M., George F., Brouqui P., Sampol J., and Raoult D. Diagnosis of Mediterranean spotted fever by indirect immunofluorescence of Rickettsia conorii in circulating endothelial cells isolated with monoclonal antibody-coated immunomagnetic beads. J Infect Dis 166 (1992) 660-663
50. Woywodt A., Streiber F., de Groot K., Regelsberger H., Haller H., and Haubitz M. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 361 (2003) 206-210
51. Nakatani K., Takeshita S., Tsujimoto H., Kawamura Y., Tokutomi T., and Sekine I. Circulating endothelial cells in Kawasaki disease. Clin Exp Immunol 131 (2003) 536-540
52. Clancy R., Marder G., Martin V., Belmont H.M., Abramson S.B., and Buyon J. Circulating activated endothelial cells in systemic lupus erythematosus: further evidence for diffuse vasculopathy. Arthritis Rheum 44 (2001) 1203-1208
53. Del Papa N., Colombo G., Fracchiolla N., et al. Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis. Arthritis Rheum 50 (2004) 1296-1304
54. Popa E.R., Kas-Deelen A.M., Hepkema B.G., Van Son W.J., The T.H., and Harmsen M.C. Donor-derived circulating endothelial cells after kidney transplantation. Transplantation 74 (2002) 1320-1327
55. Woywodt A., Schroeder M., Gwinner W., et al. Elevated numbers of circulating endothelial cells in renal transplant recipients. Transplantation 76 (2003) 1-4
56. Woywodt A., Scheer J., Hambach L., et al. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood 103 (2004) 3603-3605
57. Mancuso P., Calleri A., Cassi C., et al. Circulating endothelial cells as a novel marker of angiogenesis. Adv Exp Med Biol 522 (2003) 83-97
58. Mancuso P., Burlini A., Pruneri G., Goldhirsch A., Martinelli G., and Bertolini F. Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 97 (2001) 3658-3661
59. Beerepoot L.V., Mehra N., Vermaat J.S., Zonnenberg B.A., Gebbink M.F., and Voest E.E. Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients. Ann Oncol 15 (2004) 139-145
60. George F., Brouqui P., Boffa M.C., et al. Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood 82 (1993) 2109-2116
61. Percivalle E., Revello M.G., Vago L., Morini F., and Gerna G. Circulating endothelial giant cells permissive for human cytomegalovirus (HCMV) are detected in disseminated HCMV infections with organ involvement. Circulating endothelial giant cells permissive for human cytomegalovirus (HCMV) are detected in disseminated HCMV infections with organ involvement. J Clin Invest 92 (1993) 663-670
62. Beerepoot L.V., Mehra N., Linschoten F., et al. Circulating endothelial cells in cancer patients do not express tissue factor. Cancer Lett 213 (2004) 241-248
63. Mutin M., Canavy I., Blann A., Bory M., Sampol J., and Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood 93 (1999) 2951-2958
64. Quilici J., Banzet N., Paule P., et al. Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary syndromes. Circulation 110 (2004) 1586-1591
65. Lee K.W., Lip G.Y., Tayebjee M., Foster W., and Blann A.D. Circulating endothelial cells, von Willebrand factor, interleukin-6, and prognosis in patients with acute coronary syndromes. Blood 105 (2005) 526-532
66. Wang C., Li H., Fu P., Zhang S., and Xiu R. Serum C-reactive protein and circulating endothelial cells in patients with acute myocardial infarction. Clin Hemorheol Microcirc 32 (2005) 287-296
67. Freestone B., Chong A.Y., Nadar S., Lee K.W., Lip G.Y.H., and Blann A.D. Circulating endothelial cells in atrial fibrillation with and without acute cardiovascular disease. Thromb Haemost 94 (2005) 702-706
68. Nadar S., Lip G.Y.H., and Blann A.D. Circulating endothelial cells in acute ischaemic stroke. Thromb Haemost 94 (2005) 707-712
69. Blann A.D., Naqvi T., Waite M., and McCollum C.N. von Willebrand factor and endothelial cell damage in essential hypertension. J Hum Hypertens 7 (1993) 107-111
70. Chong A.Y., Lip G.Y.H., Freestone B., and Blann A.D. Increased circulating endothelial cells in acute congestive heart failure: comparison with von Willebrand factor and soluble E selectin. Eur J Heart Fail 8 (2006) 167-172
71. McClung J.A., Naseer N., Saleem M., et al. Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia 48 (2005) 345-350
72. Koc M., Richards H.B., Bihorac A., Ross E.A., Schold J.D., and Segal M.S. Circulating endothelial cells are associated with future vascular events in hemodialysis patients. Kidney Int 67 (2005) 1078-1083
73. Mutunga M., Fulton B., Bullock R., et al. Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 163 (2001) 195-200
74. Kocher A.A., Schuster M.D., Szabolcs M.J., et al. Neovascularisation of ischaemic myocardium by human bone marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodelling and improves cardiac function. Nat Med 7 (2001) 430-436
75. Asahara T., Matsuda H., Takahashi T., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularisation. Circ Res 85 (1999) 221-228
76. Szmitko P.E., Fedak P.W., Weisel R.D., Stewart D.J., Kutryk M.J., and Verma S. Endothelial progenitor cells: new hope for a broken heart. Circulation 107 (2003) 3093-3100
77. Rafii S., Meeus S., Dias S., et al. Contribution of marrow-derived progenitors to vascular and cardiac regeneration. Semin Cell Dev Biol 13 (2002) 61-67
78. Adams V., Lenk K., Linke A., et al. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol 24 (2004) 684-690
79. Hill J.M., Zalos G., Halcox J.P., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348 (2003) 593-600
80. Eizawa T., Ikeda U., Murakami Y., et al. Decrease in circulating endothelial progenitor cells in patients with stable coronary artery disease. Heart 90 (2004) 685-686
81. Roberts N., Jahangiri M., and Xu Q. Progenitor cells in vascular disease. J Cell Mol Med 9; (2005) 583-591
82. Leone A.M., Rutella S., Bonanno G., et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 26 (2005) 1196-1204
83. Massa M., Rosti V., Ferrario M., et al. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood 105 (2005) 199-206
84. Shintani S., Murohara T., Ikeda H., et al. Mobilisation of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 103 (2001) 2776-2779
85. Steiner S., Niessner A., Ziegler S., et al. Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 181 (2005) 305-310
86. Walter D.H., Rittig K., Bahlmann F.H., et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 105 (2002) 3017-3024
87. Vasa M., Fichtlscherer S., Adler K., et al. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 103 (2001) 2885-2890
88. Ingram D.A., Mead L.E., Tanaka H., et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 104 (2004) 2752-2760
89. Burger P.E., Coetzee S., McKeehan W.L., et al. Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells. Blood 100 (2002) 3527-3535
90. Walenta K., Friedrich E.B., Sehnert F., Werner N., and Nickenig G. In vitro differentiation characteristics of cultured human mononuclear cells-implications for endothelial progenitor cell biology. Biochem Biophys Res Commun 333 (2005) 476-482
91. Nakatani K., Takeshita S., Tsujimoto H., Kawamura Y., Tokutomi T., and Sekine I. Circulating endothelial cells in Kawasaki disease. Clin Exp Immunol 131 (2003) 536-540
92. Ingram D.A., Caplice N.M., and Yoder M.C. Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood 106 (2005) 1525-1531
93. Schmeisser A., Garlichs C.D., Zhang H., et al. Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions. Cardiovasc Res 49 (2001) 671-680
94. Rehman J., Li J., Orschell C.M., and March K.L. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107 (2003) 1164-1169
95. Rohde E., Malischnik C., Thaler D., et al. Blood monocytes mimic endothelial progenitor cells. Stem Cells 24 (2006) 351-367
96. Gulati R., Jevremovic D., Peterson T.E., et al. Diverse origin and function of cells with endothelial phenotype obtained from adult human blood. Circ Res 93 (2003) 1023-1025
97. Romagnani P., Annunziato F., Liotta F., et al. CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res 97 (2005) 314-322
98. Lin Y., Weisdorf D.J., Solovey A., et al. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105 (2000) 71-77
99. Rehman J., Li J., Orschell C.M., and March K.L. Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107 (2003) 1164-1169
100. Fernandez Fernandez Pujol B., Lucibello F.C., Gehling U.M., et al. Endothelial-like cells derived from human C14 positive monocytes. Differentiation 65 (2000) 287-300
101. Werner N., Kosiol S., Schiegl T., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353 (2005) 999-1007
102. Woywodt A., Blann A.D., Kirsch T., et al. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 4 (2006) 671-677
103. Bonello L., Basire A., Sabatier F., Paganelli F., and Dignat-George F. Endothelial injury induced by coronary angioplasty triggers moblization of endothelial progenitor cells in patients with stable coronary artery disease. J Thromb Haemost 4 (2006) 979-981