-
1
-
-
0141528828
-
Chronic myeloid leukemia-advances in biology and new approaches to treatment
-
Goldman JM, Melo JV. Chronic myeloid leukemia-advances in biology and new approaches to treatment. N Engl J Med 2003; 349: 1451-1464.
-
(2003)
N Engl J Med
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
2
-
-
4344623889
-
Imatinib as a paradigm of targeted therapies
-
Druker BJ. Imatinib as a paradigm of targeted therapies. Adv Cancer Res 2004; 91: 1-30.
-
(2004)
Adv Cancer Res
, vol.91
, pp. 1-30
-
-
Druker, B.J.1
-
3
-
-
4344672552
-
Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
-
Hochhaus A, La Rosée P. Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance. Leukemia 2004; 18: 1321-1331.
-
(2004)
Leukemia
, vol.18
, pp. 1321-1331
-
-
Hochhaus, A.1
La Rosée, P.2
-
4
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
Hughes TP, Kaeda J, Branford S et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349: 1423-1432.
-
(2003)
N Engl J Med
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
Kaeda, J.2
Branford, S.3
-
5
-
-
9144253153
-
Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C
-
Mueller MC, Gattermann N, Lahaye T et al. Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C. Leukemia 2003; 17: 2392-2400.
-
(2003)
Leukemia
, vol.17
, pp. 2392-2400
-
-
Mueller, M.C.1
Gattermann, N.2
Lahaye, T.3
-
6
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian H, Sawyers C, Hochhaus A et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346: 645-652.
-
(2002)
N Engl J Med
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
Sawyers, C.2
Hochhaus, A.3
-
7
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Gullhot F, Larson RA et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Gullhot, F.2
Larson, R.A.3
-
8
-
-
0037085785
-
Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
-
Talpaz M, Silver RT, Druker BJ et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study. Blood 2002; 99: 1928-1937.
-
(2002)
Blood
, vol.99
, pp. 1928-1937
-
-
Talpaz, M.1
Silver, R.T.2
Druker, B.J.3
-
9
-
-
0037093092
-
Imatinib induces hematologic and cytogenetic responses in patents with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
-
Sawyers CL, Hochhaus A, Feldman E et al. Imatinib induces hematologic and cytogenetic responses in patents with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study. Blood 2002; 99: 3530-3539.
-
(2002)
Blood
, vol.99
, pp. 3530-3539
-
-
Sawyers, C.L.1
Hochhaus, A.2
Feldman, E.3
-
10
-
-
20144388183
-
Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5-year follow-up
-
Lahaye T, Riehm B, Berger U et al. Response and resistance in 300 patients with BCR-ABL-positive leukemias treated with imatinib in a single center: A 4.5-year follow-up. Cancer 2005; 103: 1659-1669.
-
(2005)
Cancer
, vol.103
, pp. 1659-1669
-
-
Lahaye, T.1
Riehm, B.2
Berger, U.3
-
11
-
-
0036850514
-
Molecular and chromosomal mechanisms of resistance to imatinib (ST1571) therapy
-
Hochhaus A, Kreil S, Corbin AS et al. Molecular and chromosomal mechanisms of resistance to imatinib (ST1571) therapy. Leukemia 2002; 16: 2190-2196.
-
(2002)
Leukemia
, vol.16
, pp. 2190-2196
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.S.3
-
12
-
-
0035800507
-
Clinical resistance to ST1-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to ST1-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-880.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
13
-
-
23044458596
-
ABL mutations in late chronic phase chronic myeloid leukemia patents with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S, Martinelli G, Rosti G et al. ABL mutations in late chronic phase chronic myeloid leukemia patents with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: A study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005; 23: 4100-4109.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4100-4109
-
-
Soverini, S.1
Martinelli, G.2
Rosti, G.3
-
14
-
-
3042612211
-
Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib
-
Soverini S, Martinelli G, Amabile M et al. Denaturing-HPLC-based assay for detection of ABL mutations in chronic myeloid leukemia patients resistant to Imatinib. Clin Chem 2004; 50: 1205-1213.
-
(2004)
Clin Chem
, vol.50
, pp. 1205-1213
-
-
Soverini, S.1
Martinelli, G.2
Amabile, M.3
-
15
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (ST1571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (ST1571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2: 117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
-
16
-
-
0038700994
-
Cytogenetic and molecular mechanisms of resistance to imatinib
-
Hochhaus A. Cytogenetic and molecular mechanisms of resistance to imatinib. Semin Hematol 2003; 40 (Suppl 2): 69-79.
-
(2003)
Semin Hematol
, vol.40
, Issue.SUPPL. 2
, pp. 69-79
-
-
Hochhaus, A.1
-
17
-
-
0035929652
-
Roots of clinical resistance to ST1-571 cancer therapy
-
Hochhaus A, Kreil S, Corbin A et al. Roots of clinical resistance to ST1-571 cancer therapy. Science 2001; 293: 2163.
-
(2001)
Science
, vol.293
, pp. 2163
-
-
Hochhaus, A.1
Kreil, S.2
Corbin, A.3
-
18
-
-
0034665713
-
Structural mechanism for ST1-571 inhibition of abelson tyrosine kinase
-
Schindler T, Bornmann W, Pellicena P et al, Structural mechanism for ST1-571 inhibition of abelson tyrosine kinase. Science 2000; 289: 1938-1942.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
-
19
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001; 344: 1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
20
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
21
-
-
10744231480
-
Result of high-dose imatinib mesylate in patents with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha
-
Cortes J, Giles F, O'Brien S et al. Result of high-dose imatinib mesylate in patents with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon-alpha. Blood 2003; 102: 83-86.
-
(2003)
Blood
, vol.102
, pp. 83-86
-
-
Cortes, J.1
Giles, F.2
O'Brien, S.3
-
22
-
-
0037438467
-
Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
-
Kantarjian HM, Talpaz M, O'Brien S et al. Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood 2003; 101: 473-475.
-
(2003)
Blood
, vol.101
, pp. 473-475
-
-
Kantarjian, H.M.1
Talpaz, M.2
O'Brien, S.3
-
23
-
-
1542713480
-
P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
-
Illmer T, Schaich M, Platzbecker U et al. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004; 18: 401-408.
-
(2004)
Leukemia
, vol.18
, pp. 401-408
-
-
Illmer, T.1
Schaich, M.2
Platzbecker, U.3
-
24
-
-
0042305479
-
Apha1 acid glycoprotein binds to imatinib (ST1571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
-
Gambacorti-Passerini C, Zucchetti M, Russo D et al. Apha1 acid glycoprotein binds to imatinib (ST1571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 2003; 9: 625-632.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 625-632
-
-
Gambacorti-Passerini, C.1
Zucchetti, M.2
Russo, D.3
-
25
-
-
0037130992
-
Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells
-
Muller MC, Lahaye T, Hochhaus A. [Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells]. Dtsch Med Wochenschr 2002; 127: 2205-2207.
-
(2002)
Dtsch Med Wochenschr
, vol.127
, pp. 2205-2207
-
-
Muller, M.C.1
Lahaye, T.2
Hochhaus, A.3
-
26
-
-
9144271748
-
In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines
-
La Rosée P, Johnson K, Corbin AS et al. In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines. Blood 2004; 103: 208-215.
-
(2004)
Blood
, vol.103
, pp. 208-215
-
-
La Rosée, P.1
Johnson, K.2
Corbin, A.S.3
-
27
-
-
0036320754
-
In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia
-
La Rosée P, Johnson K, O'Dwyer ME, Druker BJ. In vitro studies of the combination of imatinib mesylate (Gleevec) and arsenic trioxide (Trisenox) in chronic myelogenous leukemia. Exp Hematol 2002; 30: 729-737.
-
(2002)
Exp Hematol
, vol.30
, pp. 729-737
-
-
La Rosée, P.1
Johnson, K.2
O'Dwyer, M.E.3
Druker, B.J.4
-
28
-
-
0036045378
-
Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: A translational perspective
-
La Rosée P, O'Dwyer ME, Druker BJ. Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: A translational perspective. Leukemia 2002; 16: 1213-1219.
-
(2002)
Leukemia
, vol.16
, pp. 1213-1219
-
-
La Rosée, P.1
O'Dwyer, M.E.2
Druker, B.J.3
-
29
-
-
1842477418
-
Imatinib and beyond-to new CML study IV. A randomized controlled comparison of imatinib vs imatinib/Interferon-alpha vs. imatinib/low-dose AraC vs. imatinib after interferon-alpha failure in newly diagnosed chronic phase chronic myeloid leukemia
-
Berger U, Engelich G, Relter A et al. Imatinib and beyond-to new CML study IV. A randomized controlled comparison of imatinib vs imatinib/ Interferon-alpha vs. imatinib/low-dose AraC vs. imatinib after interferon-alpha failure in newly diagnosed chronic phase chronic myeloid leukemia. Ann Hematol 2004; 83: 258-264.
-
(2004)
Ann Hematol
, vol.83
, pp. 258-264
-
-
Berger, U.1
Engelich, G.2
Relter, A.3
-
30
-
-
10744230175
-
The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase
-
Sneed TB, Kantarjian HM, Talpaz M et al. The significance of myelosuppression during therapy with imatinib mesylate in patients with chronic myelogenous leukemia in chronic phase. Cancer 2004; 100: 116-121.
-
(2004)
Cancer
, vol.100
, pp. 116-121
-
-
Sneed, T.B.1
Kantarjian, H.M.2
Talpaz, M.3
-
31
-
-
0141539511
-
Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI)
-
Gozzetti A, Tozzuoli D, Crupi R et al. Emergence of Ph negative clones in chronic myeloid leukemia (CML) patients in complete cytogenetic remission after therapy with imatinib mesylate (STI), Eur J Haematol 2003; 71: 313-314.
-
(2003)
Eur J Haematol
, vol.71
, pp. 313-314
-
-
Gozzetti, A.1
Tozzuoli, D.2
Crupi, R.3
-
32
-
-
0036720397
-
The impact of clonal evolution on response to imatinib mesylate (ST1571) in accelerated phase CML
-
O'Dwyer ME, Mauro MJ, Kurilik G et al. The impact of clonal evolution on response to imatinib mesylate (ST1571) in accelerated phase CML. Blood 2002; 100: 1628-1633.
-
(2002)
Blood
, vol.100
, pp. 1628-1633
-
-
O'Dwyer, M.E.1
Mauro, M.J.2
Kurilik, G.3
-
33
-
-
0038092769
-
Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority
-
Bumm T, Muller C, Al-Ali HK et al. Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority. Blood 2003; 101: 1941-1949.
-
(2003)
Blood
, vol.101
, pp. 1941-1949
-
-
Bumm, T.1
Muller, C.2
Al-Ali, H.K.3
-
34
-
-
0037346124
-
Chronic myeloid leukemia in chronic phase responding to imatinib: The occurrence of additional cytogenetic abnormalities predicts disease progression
-
Marktel S, Marin D, Foot N, et al. Chronic myeloid leukemia in chronic phase responding to imatinib: The occurrence of additional cytogenetic abnormalities predicts disease progression. Haematologica 2003; 88: 260-267.
-
(2003)
Haematologica
, vol.88
, pp. 260-267
-
-
Marktel, S.1
Marin, D.2
Foot, N.3
-
35
-
-
15044341318
-
Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha
-
Bacher U, Hochhaus A, Berger U et al. Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha. Leukemia 2006; 19: 460-463.
-
(2006)
Leukemia
, vol.19
, pp. 460-463
-
-
Bacher, U.1
Hochhaus, A.2
Berger, U.3
-
36
-
-
0345382731
-
Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate
-
O'Dwyer ME, Gatter KM, Loriaux M et al. Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate. Leukemia 2003; 17: 481-487.
-
(2003)
Leukemia
, vol.17
, pp. 481-487
-
-
O'Dwyer, M.E.1
Gatter, K.M.2
Loriaux, M.3
-
37
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
Shah NP, Tran C, Lee FY et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305: 399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
-
38
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
Weisberg E, Manley PW, Breitenstein W et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005; 7: 129-141.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
-
39
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro
-
Graham SM, Jorgensen HG, Allan E et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro. Blood 2002; 99: 319-325.
-
(2002)
Blood
, vol.99
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
-
40
-
-
0345874513
-
No correlation between the proliferative status of Bcr-Abl positive cell lines and the proapoptotic activity of imatinib mesylate (Gleevec/Glivec)
-
La Rosée P, Shen L, Stoffregen EP et al. No correlation between the proliferative status of Bcr-Abl positive cell lines and the proapoptotic activity of imatinib mesylate (Gleevec/Glivec). Hematol J 2003; 4: 413-419.
-
(2003)
Hematol J
, vol.4
, pp. 413-419
-
-
La Rosée, P.1
Shen, L.2
Stoffregen, E.P.3
|