Biological monitoring of exposure to organophosphate pesticides in children living in peri-urban areas of the Province of Quebec, Canada

International Archives of Occupational and Environmental Health

Volumn 79, Issue 7, 2006, Pages 568-577

  Valcke, Mathieu ^a   Samuel, Onil ^a   Bouchard, Michèle ^b   Dumas, Pierre ^a   Belleville, Denis ^a   Tremblay, Claude ^c  

^a INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c Direction de la Santé Publique de la Montérégie   (Canada)

Author keywords

Alkylphosphate urinary metabolites; Biological monitoring; Organophosphate pesticides; Peri urban children; Pesticide exposure

Indexed keywords

ALKYL GROUP; CREATININE; DIETHYLTHIOPHOSPHATE; DITHIOPHOSPHORIC ACID DIMETHYL ESTER; O,O DIMETHYLTHIOPHOSPHORIC ACID; ORGANOPHOSPHATE; ORGANOPHOSPHATE PESTICIDE; PHOSPHORIC ACID DIETHYL ESTER; PHOSPHORIC ACID DIMETHYL ESTER; PHOSPHORODITHIOIC ACID O,O DIETHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL MONITORING; CANADA; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE URINE LEVEL; DIETARY INTAKE; DOMESTIC ANIMAL; ENVIRONMENTAL EXPOSURE; FEMALE; FOOD CONTAMINATION; FRUIT; HUMAN; MAJOR CLINICAL STUDY; MALE; QUESTIONNAIRE; SEASONAL VARIATION; SIBLING; SPRING; STATISTICAL SIGNIFICANCE; SUMMER; URBAN AREA; URINALYSIS; VEGETABLE;

CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MALE; PESTICIDES; PHOSPHORIC ACID ESTERS; QUEBEC; SUBURBAN POPULATION;

EID: 33749591557     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-006-0085-8     Document Type: Article

References (44)

1. Adgate JL, Barr DB, Clayton A, Eberly LE, Freeman NCG, Lioy P, et al (2001) Measurement of children's exposure to pesticides: Analysis of urinary metabolite levels in a probability-based sample. Environ Health Perspect 109:583-590
2. Aprea C, Strambi M, Novelli MT, Lunghini L, Bozzi N (2000) Biologic monitoring of exposure to organophosphorus pesticides in 195 Italian children. Environ Health Perspect 108:521-525
3. Barr DB, Bravo R, Weerasekera G, Caltabiano LM, Whitehead RD Jr, Olsson AO, et al (2004) Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the US population. Environ Health Perspect 112:186-200
4. Bearer CF (1995) How are children different from adults? Environ Health Perspect 103 [Suppl 6]:7-12
5. Bell EM, Hertz-Picciotto I, Beaumont JJ (2001) A case-control study of pesticides and fetal death due to congenital anomalies. Epidemiology 12:148-156
6. Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J Liu Z et al (2003) Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ Health Perspect 111:79-84
7. Bhargava A, Hays J (2004) Behavioral variables and education are predictors of dietary change in the Women's Health Trial: Feasibility study in minority populations. Prev Med 38:442-451
8. Bouchard M, Carrier G, Brunet RC, Gosselin NH, Bonvalot Y (2005) Determination of biological reference values for chlorpyrifos metabolites in human urine using a toxicokinetic model. J Occup Environ Hyg 2:155-168
9. Bouchard M, Gosselin NH, Brunet RC, Samuel O, Dumoulin MJ, Carrier G (2003) A toxicokinetic model of malathion and its metabolites as a tool to assess human exposure and risk through measurements of urinary biomarkers. Toxicol Sci 73:182-94
10. Carrier G, Brunet RC (1999) A toxicokinetic model to assess the risk of azinphosmethyl exposure in humans through measures of urinary elimination of alkylphosphates. Toxicol Sci 47:23-32
11. CDC (2001) National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:NAtional Center for Environmental Health, Centers for Disease Control and Prevention
12. CDC (2003) Second National Report on Human Exposure to Environmental Chemicals. Atlanta, GA:NAtional Center for Environmental Health, Centers for Disease Control and Prevention
13. Curl CL, Fenske RA, Elgethun K (2003) Organophosphorus pesticides exposure of urban and suburban preschool children with organic and conventional diets. Environ Health Perspect 111:377-382
14. Eaton L (2000) Biotransformation enzyme polymorphism and pesticide susceptibility. Neurotoxicology 21:101-111
15. Eskenazi B, Bradman A, Castorina R (1999) Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ Health Perspect 107 [Suppl 3]:409-419
16. Fenske RA, Black KG, Elkner KP, Lee CL, Methner MM, Soto R (1990) Potential exposure and health risks of infants following indoor residential pesticide applications. Am J Public Health 80:689-693
17. Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL (2002) Assessment of organophosphorus pesticide exposure in the diets of pre-school children in Washington State. J Expo Anal Environ Epidemiol 12:21-28
18. Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH et al (2000) Biologically based pesticide dose estimates for children in an agricultural community. Environ Health Perspect 108:515-520
19. Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E et al (2000) Genetic and temporal determinants of pesticide sensitivity: Role of paraoxonase (PON1). Neurotoxicology 21:91-100
20. Goldman LR (1995) Children-unique and vulnerable. Environmental risks facing children and recommendations for response. Environ Health Perspect 103[Suppl 6]:13-18
21. Gorse I (2004) Quebec's Pesticide sales balance sheet for the year 2000 (in French). Québec, Ministère de l'Environnement, Envirodoq ENV/2004/0320. 70 p
22. Heudorf U, Angerer J (2001) Metabolites of organophosphorus insecticides in urine specimens from inhabitants of a residential area. Environ Res 86:80-87
23. Heudorf U, Angerer J, Drexler H (2004) Current internal exposure to pesticides in children and adolescents in Germany: Urinary levels of metabolites of pyrethroid and organophosphorus insecticides. Int Arch Occup Environ Health 77:67-72
24. Johnson RA, Harris RE, Wilke RA (2000) Are pesticides really endocrine disruptors? WMJ 99:34-38
25. Koch D, Lu C, Fisker-Andersen J, Jolley L, Fenske RA (2002) Temporal association of children's pesticide exposure and agricultural spraying: report of a longitudinal monitoring study. Environ Health Perspect 110:829-833
26. Lambert WE, Lasarev M, Muniz J, Scherer J, Rothlein J, Santana J et al (2005) Variation in organophosphate pesticide metabolites in urine of children living in agricultural communities. Environ Health Perspect 113:504-508
27. Landrigan PJ, Claudio L, Markowitz CL, Berkowitz GS, Brenner BL, Romero H, et al (1999) Pesticides and inner-city children: Exposures, risks, and prevention. Environ Health Perspect 107 [Suppl 3]: 431-437
28. Lowenherz C, Fenske RA, Simcox NJ, Bellamy G, Kalman D (1997) Biological monitoring of organophosphorus pesticide exposure among children of agricultural workers in central Washington State. Environ Health Perspect 105:1344-1353
29. Lu C, Knutson DE, Fisker-Andersen J, Fenske RA (2001) Biological monitoring survey of organophosphorus pesticide exposure among pre-school children in the Seattle metropolitan area. Environ Health Perspect 109:299-303
30. MacIntosh DL, Kabiru CW, Ryan B (2001) Longitudinal investigation of dietary exposure to selected pesticides. Environ Health Perspect 109:1-6
31. Melnyk LJ, Berry MR, Sheldon LS (1997) Dietary exposure from pesticide application on farms in the Agricultural Health Pilot Study. J Expo Anal Environ Epidemiol 7:61-80
32. National Research Council. Committee on Pesticides in the Diets of Infants and Children. (1993) Pesticides in the Diets of Infants and Children. National Academy Press, Washington DC
33. O'Rourke MK, Lizardi PS, Rogan SP, Freeman NC, Aguirre A, Saint CG (2000) Pesticide exposure and creatinine variation among young children. J Expo Anal Environ Epidemiol 10:678-681
34. Reed KJ, Jimenez M, Freeman NC, Lioy PJ (1999) Quantification of children's hand and mouthing activities through a videotaping methodology. J Expo Anal Environ Epidemiol 9:513-520
35. Repetto R, Baliga SS (1997) Pesticides and immunosuppression: The risks to public health. Health Policy Plan 12:97-106
36. Shalat ST, Donnelly KC, Freeman NCG, Calvin JA, Ramesh S, Jimenez M et al (2003) Nondietary ingestion of pesticides by children in an agricultural community on the US/Mexico border: Preliminary results. J Expo Anal Environ Epidemiol 13:42-50
37. Shaw GM, Wasserman CR, O'Malley CD, Nelson V, Jackson RJ (1999) Maternal pesticide exposure from multiple sources and selected congenital anomalies. Epidemiology 10:60-66
38. Shurdut BA, Barraj L, Francis M (1998) Aggregate exposures under the Food Quality Protection Act: An approach using chlorpyrifos. Regul Toxicol Pharmacol 28:165-177
39. Simcox NJ, Fenske RA, Wolz SA, Lee I, Kalman DA (1995) Pesticides in household dust and soil: Exposure pathways for children of agricultural families. Environ Health Perspect 103:1126-1134
40. Timchalk C, Kousba A, Poet TS (2002) Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. Toxicol Lett 135:51-59
41. Vereecken CA, Keukelier E, Maes L (2004) Influence of mother's educational level on food parenting practices and food habits of young children. Appetite 43:93-103
42. Zahm SH, Ward M (1998) Pesticides and childhood cancer. Environ Health Perspect 106:893-908
43. Zartarian V, Ferguson AC, Leckie JO (1997) Quantified dermal activity data from a four-child pilot field study. J Expo Anal Environ Epidemiol 7:543-553
44. Zartarian V, Streicker J, Rivera A, Cornejo C, Molina S, Valedex O et al (1995) A pilot study to collect microactivity data on two-to-four-year-old farm labor children in Salinas Valley, California. J Expo Anal Environ Epidemiol 5:21-34