Zinc is a negative regulator of hepatitis C virus RNA replication

Liver International

Volumn 26, Issue 9, 2006, Pages 1111-1118

  Yuasa, Kazuhisa ^a   Naganuma, Atsushi ^a   Sato, Ken ^a   Ikeda, Masanori ^b   Kato, Nobuyuki ^b   Takagi, Hitoshi ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Genome length HCV RNA; Hepatitis C virus; Replication; Subgenomic HCV replicon; Zinc

Indexed keywords

ALPHA INTERFERON; IRON SALT; TRACE ELEMENT; VIRUS PROTEIN; VIRUS RNA; ZINC;

ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPLICON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS GENOME; VIRUS REPLICATION; WESTERN BLOTTING;

CELL LINE; CELL SURVIVAL; CYTOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOME, VIRAL; HEPACIVIRUS; HUMANS; INTERFERON-ALPHA; IRON COMPOUNDS; LUCIFERASES, RENILLA; REPLICON; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRAL PROTEINS; VIRUS REPLICATION; ZINC COMPOUNDS;

EID: 33749589705     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01352.x     Document Type: Article

References (35)

1. Seeff L B. Natural history of chronic hepatitis C. Hepatology 2002; 36: S35-46.
2. Yoshida H, Arakawa Y, Sata M, et al. Interferon therapy prolonged life expectancy among chronic hepatitis C patients. Gastroenterology 2002; 123: 483-91.
3. Fried M W, Shiffman M L, Reddy K R, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-82.
4. Manns M P, McHutchison J G, Gordon S C, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Lancet 2001; 358: 958-65.
5. Shi S T, Lai M M. Hepatitis C viral RNA: Challenges and promises. Cell Mol Life Sci 2001; 58: 1276-95.
6. Bartenschlager R, Lohmann V. Replication of hepatitis C virus. J Gen Virol 2000; 81: 1631-48.
7. MacDonald R S. The role of zinc in growth and cell proliferation. J Nutr 2000; 130: 1500S-8S.
8. Powell S R. The antioxidant properties of zinc. J Nutr 2000; 130: 1447S-54S.
9. Hijikata M, Mizushima H, Tanji Y, et al. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc Natl Acad Sci 1993; 90: 10773-7.
10. Thibeault D, Maurice R, Pilote L, Lamarre D, Pause A. In vitro characterization of a purified NS2/3 protease variant of hepatitis virus. J Biol Chem 2001; 276: 46678-84.
11. Stempniak M, Hostomska Z, Nodes B R, Hostomsky Z. The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme. J Biol Chem 1997; 71: 2881-6.
12. Tellinghuisen T L, Marcotrigiano J, Gorbalenya A E, Rice C M. The NS5A protein of hepatitis C virus is a zinc metalloprotein. J Biol Chem 2004; 279: 48576-87.
13. Tellinghuisen T L, Marcotrigiano J, Rice C M. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 2005; 435: 374-9.
14. Haraguchi Y, Sakurai H, Hussain S, Anner B M, Hoshino H. Inhibition of HIV-1 infection by zinc group metal compounds. Antiviral Res 1999; 43: 123-33.
15. Novick S G, Godfrey J C, Pollack R L, Wilder H R. Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants. Med Hypotheses 1997; 49: 347-57.
16. Kumel G, Schrader S, Zentgraf H, Brendel M. Therapy of banal HSV lesions: Molecular mechanisms of the antiviral activity of zinc sulfate. Hautarzt 1991; 42: 439-45.
17. Suara R O, Crowe J E Jr. Effect of zinc salts on respiratory syncytial virus replication. Antimicrob Agents Chemother 2004; 48: 783-90.
18. Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005; 11: 791-6.
19. Lohmann V, Korner F, Koch J, Herian U, Theilmann L, Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999; 285: 110-3.
20. Bartenschlager R. The hepatitis C virus replicon system: From basic research to clinical application. J Hepatol 2005; 43: 210-6.
21. Ikeda M, Yi M, Li K, Lemon S M. Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells. J Virol 2002; 76: 2997-3006.
22. Blight K J, McKeating J A, Marcotrigiano J, Rice C M. Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture. J Virol 2003; 77: 3181-90.
23. Pietschmann T, Lohmann V, Kaul A, et al. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. J Virol 2002; 76: 4008-21.
24. Ikeda M, Abe K, Dansako H, Nakamura T, Naka K, Kato N. Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system. Biochem Biophys Res Commun 2005; 329: 1350-9.
25. Ebara M, Fukuda H, Hatano R, et al. Metal contents in the liver of patients with chronic liver disease caused by hepatitis C virus. Oncology 2003; 65: 323-30.
26. Chapoutot C, Esslimani M, Joomaye Z, et al. Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis. Gut 2000; 46: 711-4.
27. Nagamine T, Takagi H, Takayama H, et al. Preliminary study of combination therapy with IFN-alpha and zinc in chronic hepatitis C patients with genotype Ib. Biol Trace Element Res 2000; 75: 53-63.
28. Takagi H, Nagamine T, Abe T, et al. Zinc supplementation enhances the response to interferon therapy in patients with hepatitis C. J Viral Hepat 2001; 8: 367-71.
29. Kato N, Sugiyama K, Namba K, et al. Establishment of a hepatitis C virus subgenomic replicon derived from human hepatocytes infected in vitro. Biochem Biophys Res Commun 2003; 306: 756-66.
30. Pietschmann T, Lohmann V, Rutter G, Kurpanek K, Bartenschlager R. Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. J Virol 2001; 75: 1252-64.
31. Fillebeen C, Rivas-Estilla A M, Bisaillon M, et al. Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C virus. J Biol Chem 2005; 280: 9049-57.
32. Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotono K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282-8.
33. Naganuma A, Nozaki A, Tanaka T, et al. Activation of the interferon-inducible 2′-5′-oligoadenylate synthetase gene by hepatitis C virus core protein. J Virol 2000; 74: 8744-50.
34. Tanabe Y, Sakamoto N, Enomoto N, et al. Synergistic inhibition of intercellular hepatitis C virus replication by combination of ribavirin and interferon-alpha. J Infect Dis 2004; 189: 1129-39.
35. Naka K, Ikeda M, Abe K, Dansako H, Kato N. Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-alpha. Biochem Biophys Res Commun 2005; 330: 871-9.