Nicotine suppression of gustatory responses of neurons in the nucleus of the solitary tract

Journal of Neurophysiology

Volumn 96, Issue 4, 2006, Pages 1877-1886

  Simons, Christopher T ^b   Boucher, Yves ^c   Carstens, Mirela Iodi ^a   Carstens, E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Givaudan Roure Corporation   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CITRIC ACID; GLUTAMATE SODIUM; MECAMYLAMINE; NICOTINE; PENTOBARBITAL; QUININE; SODIUM CHLORIDE; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; EVOKED RESPONSE; EXCITATION; GANGLIONECTOMY; GUSTATORY NERVOUS SYSTEM; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECORDING; SOLITARY TRACT NUCLEUS; TONGUE; TRIGEMINAL NERVE;

ANIMALS; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SENSORY; GANGLIONIC STIMULANTS; MALE; MECAMYLAMINE; NEURONS, AFFERENT; NICOTINE; NICOTINIC ANTAGONISTS; RATS; RATS, SPRAGUE-DAWLEY; SOLITARY NUCLEUS; TASTE; TONGUE;

EID: 33749538094     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00345.2006     Document Type: Article

References (38)

1. Boucher Y, Simons CT, Faurion A, Azerad J, and Carstens E. Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract. Brain Res 973: 265-274, 2003.
2. Bradley RM and Grabauskas G. Neural circuits for taste. Excitation, inhibition, and synaptic plasticity in the rostral gustatory zone of the nucleus of the solitary tract. Ann NY Acad Sci 855C: 467-474, 1998.
3. Carstens E, Kuenzler N, and Handwerker HO. Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. J Neurophysiol 80: 465-492, 1998.
4. Carstens E, Simons CT, Dessirier JM, Carstens MI, and Jinks SL. Role of neuronal nicotinic-acetylcholine receptors in the activation of neurons in trigeminal subnucleus caudalis by nicotine delivered to the oral mucosa. Exp Brain Res 132: 375-383, 2000.
5. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zucker CS, and Ryba NJ. T2Rs function as bitter taste receptors. Cell 100: 703-711, 2000.
6. Dahl M, Erickson RP, and Simon SA. Neural responses to bitter compounds in rats. Brain Res 756: 22-34, 1997.
7. Davis BJ. GABA-like immunoreactivity in the gustatory zone of the nucleus of the solitary tract in the hamster: light and electron microscopic studies. Brain Res Bull 30: 69-77, 1993.
8. Davis BJ and Kream RM. Distribution of tachykinin- and opioid-expressing neurons in the hamster solitary nucleus: an immuno- and in situ hybridization histochemical study. Brain Res 616: 6-16, 1993.
9. Dessirier JM, Chang HK, O'Mahony M, and Carstens E. Cross-desensitization of capsaicin-evoked oral irritation by high but not low concentrations of nicotine in human subjects. Neurosci Lett 290: 133-136, 2000a.
10. Dessirier JM, O'Mahony M, and Carstens E. Oral irritant effects of nicotine: psychophysical evidence for decreased sensation following repeated application and lack of cross-desensitization to capsaicin. Chem Senses 22: 483-492, 1997.
11. Dessirier JM, O'Mahony M, Sieffermann JM, and Carstens E. Mecamylamine inhibits nicotine but not capsaicin irritation on the tongue: psychophysical evidence that nicotine and capsaicin activate separate molecular receptors. Neurosci Lett 240: 65-68, 1998.
12. Dessirier JM, Simons CT, Sudo M, Sudo S, and Carstens E. Sensitization, desensitization, and stimulus-induced recovery of trigeminal neuronal responses to oral capsaicin and nicotine. J Neurophysiol 84: 1851-1862, 2000b.
13. Forster C and Handwerker HO. Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 31: 109-118, 1990.
14. Frank ME, Formaker BK, and Hettinger TP. Peripheral gustatory processing of sweet stimuli by golden hamsters. Brain Res Bull 66: 70-84, 2005.
15. Gotti C and Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74: 363-396, 2004.
16. Green BG and Schullery MT. Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Chem Senses 28: 45-55, 2003.
17. Grunberg NE. The effects of nicotine and cigarette smoking on food consumption and taste preferences. Addict Behav 7: 317-331, 1982.
18. Hamilton RB and Norgren R. Central projections of gustatory nerves in the rat. J Comp Neurol 222: 560-577, 1984.
19. Holladay MW, Dart MJ, and Lynch JK. Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Chem 40: 4169-4194, 1997.
20. Jacquin MF, Semba K, Egger MD, and Rhoades RW. Organization of HRP-labeled trigeminal mandibular primary afferent neurons in the rat. J Comp Neurol 215: 397-420, 1983.
21. Jarvik ME and Assil KM. Mecamylamine blocks the burning sensation of nicotine on the tongue. Chem Senses 13: 213-217, 1988.
22. Jinks SL and Carstens E. Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine. J Neurophysiol 82: 3046-3055, 1999.
23. Katz DB, Simon SA, and Nicolelis MA. Dynamic and multimodal responses of gustatory cortical neurons in awake rats. J Neurosci 21: 4478-4489, 2001.
24. Lemon CH and Smith DV. Neural representation of bitter taste in the nucleus of the solitary tract. J Neurophysiol 94: 3719-3729, 2005.
25. Liu L, Pugh W, Ma H, and Simon SA. Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons. Brain Res 617: 37-42, 1993.
26. Liu L and Simon SA. Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons. Am J Physiol Cell Physiol 270: C1807-C1814, 1996.
27. Liu L, Zhu W, Zhang ZS, Yang T, Grant A, Oxford G, and Simon SA. Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. J Neurophysiol 91: 1482-1491, 2004.
28. Lynch WC, Watt J, Krall S, and Paden CM. Autoradiographic localization of κ opiate receptors in CNS taste and feeding areas. Pharmacol Biochem Behav 22: 699-705, 1985.
29. Marfurt CF and Rajchert DM. Trigeminal primary afferent projections to "non-trigeminal" areas of the rat central nervous system. J Comp Neurol 303: 483-511, 1991.
30. Mueller KL, Hoon MA, Erlenbach I, Chandrashekar J, Zuker CS, and Ryba NJ. The receptors and coding logic for bitter taste. Nature 434: 225-229, 2005.
31. 2+ in taste cells via activation of muscarinic receptors. J Neurophysiol 87: 2643-2649, 2002.
32. Scott TR, Giza BK, and Yan J. Gustatory neural coding in the cortex of the alert cynomolgus macaque: the quality of bitterness. J Neurophysiol 81: 60-71, 1999.
33. Simons CT, Boucher Y, and Carstens E. Suppression of central taste transmission by oral capsaicin. J Neurosci 23: 978-985, 2003a.
34. Simons CT, O'Mahony M, and Carstens E. Taste suppression following lingual capsaicin pre-treatment in humans. Chem Senses 27: 353-365, 2002.
35. Simons CT, Sudo S, Sudo M, and Carstens E. Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation. Brain Res 991: 249-253, 2003b.
36. Smith DV, Ye MK, and Li CS. Medullary taste responses are modulated by the bed nucleus of the stria terminalis. Chem Senses 30: 421-434, 2005.
37. Sudo S, Sudo M, Simons CT, Dessirier JM, and Carstens E. Sensitization of trigeminal caudalis neuronal responses to intraoral acid and salt stimuli and desensitization by nicotine. Pain 98: 277-286, 2002.
38. Whitehead MC and Frank ME. Anatomy of the gustatory system in the hamster: central projections of the chorda-tympani and the lingual nerve. J Comp Neurol 220: 378-395, 1983.