Capsaicin and nicotine both activate a subset of rat trigeminal ganglion neurons

American Journal of Physiology - Cell Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Liu, L ^a   Simon, S A ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

calcium; irritant; pain; taste

Indexed keywords

CAPSAICIN; NICOTINE; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; NERVE POTENTIAL; NERVE STIMULATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; TACHYPHYLAXIS; TRIGEMINUS GANGLION;

EID: 0029770120     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.270.6.c1807     Document Type: Article

References (28)

1. Amann, R., and C. A. Maggi. Ruthenium red as a capsaicin agonist. Life Sci. 49: 849-856, 1991.
2. Benowitz, N. L., H. Porchet, and P. Jacob III. Pharmokinetics, metabolism, and pharmacodynamics of nicotine. In: Nicotine Psychopharmacology: Molecular, Cellular, and Behavioural Aspects, edited by S. Wonnacott, M. A. H. Russell and I. P Stolerman. Oxford, UK: Oxford University Press, 1990, p. 112-157.
3. Bevan, S., and R. J. Docherty. Cellular mechanisms of the action of capsaicin. In: Capsaicin in the Study of Pain, edited by J. Wood. London: Academic, 1993, p. 27-44.
4. Chard, P. S., D. Bleakman, J. R. Savidge, and R. J. Miller. Capsaicin-induced neurotoxicity in cultured doral root ganglion neurons: involvement of calcium-activated proteases. Neuroscience 65: 1099-1108, 1995.
5. Collins, A. C., Y. Luo, S. Selvaag, and M. L. Marks. Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mercamylamine infusion. J. Pharmacol. Exp. Ther. 271: 125-133, 1994.
6. Dray, A., J. Bettaney, and P. Forster. Actions of capsaicin on peripherial nociceptors of the neonatal rat spinal cord-tail in vitro: dependence of extracellular ions and independence of second messengers. Br. J. Pharmacol. 101: 727-733, 1990.
7. Duner-Engstrom, M., B. B. Fredholm, O. Larsson, J. M. Lundberg, and A. Saria. Autonomic mechanisms underlying capsaicin induced oral sensations and salivation in man. J. Physiol. Lond. 373: 87-95, 1986.
8. Franco-Cereceda, A., G. Kallner, and J. M. Lundberg. Capsazepine-sensitive release of calcitonin gene related peptide from C-fibre afferents in the guinea pig heart by low pH and lactic acid. Eur. J. Pharmacol. 238: 311-316, 1993.
9. Holzer, P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 43: 143-201, 1991.
10. Jancso, N., A. Jancso-Gabor, and I. Tataks. Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizating agents. Acta Physiol. Hung. 19: 119-132, 1961.
11. Jinno, S., X. Y. Hus, and T. L. Yaksh. Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea. J. Appl. Physiol. 76: 1651-1656, 1994.
12. Kuo, H.-P., J. A. L. Rohde, P. J. Barnes, and D. F. Rogers. Cigarette smoke-induced airway goblet cell secretion: dose-dependent differential nerve activation. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L161-L167, 1992.
13. Liu, L., H. Ma, W. Pugh, and S. A. Simon. Identification of acetylcholine receptors in adult rat trigeminal ganglion neurons. Brain Res. 617: 37-42, 1993.
14. Liu, L., and S. A. Simon. A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc. Natl. Acad. Sci. USA. 91: 738-741, 1994.
15. 2+ dependence in rat trigeminal ganglion cells. J. Neurophysiol. 75: 1503-1514, 1996.
16. Lou, Y.-P., and J. M. Lundberg. Inhibition of low pH evoked activation of airway sensory nerves by capsazepine, a novel capsaicin-receptor antagonist. Biochem. Biophys. Res. Commun. 189: 537-544, 1992.
17. Lundberg, J. M.,A. Franco-Cereceda, Y. Lou, A. Modin, and J. Prenow. Differential release of classical transmitters and peptides. In: Molecular and Cellular Mechanisms of Neurotransmitter Release, edited by L. Stjarne, P. Greengard, S. Grilner, T. Hokfelt, and D. Ottoson. New York: Raven, 1994, p. 223-234.
18. Mathie, A., S. G. Cull-Candy, and D. Colquhoun. Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons in the rat. Proc. R. Soc. Lond. B Biol. Sci. 232: 239-248, 1987.
19. Mulle, C., D. Choquet, H. Korn, and J.-P. Changeux. Calcium influx through nicotinic receptor in rat central neurons: its relevance to cellular regulation. Neuron 8: 135-143, 1992.
20. Mulle, C., C. Lena, and J.-P. Changeux. Potentiation of nicotinic response by external calcium in rat central neurons. Neuron 8: 937-945, 1992.
21. Patrick, J., P. Sequela, S. Vernino, M. Amador, C. Leutje, and J. Dani. Functional diversity of neuronal nicotinic acetylcholine receptors. In: Progress in Brain Research, edited by A. C. Cuello. Amsterdam: Elsevier, 1993, vol. 98, p. 113-120.
22. Pearce, R. J., and M. R. Duchen. Differential expression of membrane currents in dissociated mouse primary sensory neurons. Neuroscience 63: 1041-1056, 1994.
23. Roberts, R. G. D., C. A. Stevenson, R. A. Westerman, and J. Pennyfeather. Nicotinic acetylcholine receptors on capsaicin-sensitive afferents. Neuroreport 6: 1578-1582, 1995.
24. Sekizawa, S.-I., and H. Tsubone. Nasal receptors responding to noxious chemical irritants. Respir. Physiol. 96: 37-48, 1994.
25. Stjarne, P., L. Lundblad, and J. Rinder. Ruthenium red selectively attenuates capsaicin induced vasodilation in pig nasal mucosa. Acta Oto-Laryngol. 114: 651-656, 1994.
26. Szallasi, A. The vanilloid (capsaicin) receptor: receptor types and species differences. Gen. Pharmacol. 25: 223-243, 1994.
27. Szolcsanyi, J. Actions of capsaicin on sensory receptors. In: Capsaicin in the Study of Pain, edited by J. Wood. London: Academic, 1993, p. 1-26.
28. Zhang, Z. W., and P. Feltz. Nicotinic acetylcholine receptors in porcine hypophyseal intermediate lobe cells. J. Physiol. Lond. 422: 83-101, 1990.