Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity

British Journal of Pharmacology

Volumn 121, Issue 5, 1997, Pages 947-954

  Orosz, Ferenc ^a   Kovács, János ^c   Löw, Péter ^c   Vértessy, Beáta G ^a   Urbányi, Zoltán ^b   Ács, Tibor ^b   Keve, Tibor ^b   Ovádi, Judit ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b GEDEON RICHTER LTD   (Hungary)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Bis indols; Microtubule; Vinblastine; Vinca alkaloids; Vincristine

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ANTIMITOTIC AGENT; CATHARANTHINE; INDOLE DERIVATIVE; KAR 2; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CELL DAMAGE; CELL DIFFERENTIATION; CELL SURFACE; CELL ULTRASTRUCTURE; CHO CELL; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG RESISTANCE; IMMUNOFLUORESCENCE; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA P 388; MICROTUBULE ASSEMBLY; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CALMODULIN; CATTLE; CHO CELLS; CRICETINAE; DRUG SCREENING ASSAYS, ANTITUMOR; IMMUNOHISTOCHEMISTRY; INSECTS; LEUKEMIA P388; MICE; MICROSCOPY, ELECTRON; PROTEIN BINDING; RATS; TUBULIN; TUMOR CELLS, CULTURED; VINBLASTINE; VINCRISTINE;

EID: 0030926468     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701189     Document Type: Article

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