A new potent calmodulin antagonist with arylalkylamine structure: Crystallographic, spectroscopic and functional studies

Journal of Molecular Biology

Volumn 297, Issue 3, 2000, Pages 747-755

  Harmat, Veronika ^a   Böcskei, Zsolt ^b   Náray Szabó, Gábor ^a   Bata, Imre ^b   Csutor, Andrea S ^b   Hermecz, István ^b   Arányi, Péter ^b   Szabó, Beáta ^c   Liliom, Károly ^c   Vértessy, Beáta G ^c   Ovádi, Judit ^c  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b Chinoin Pharmaceutical and Chemical Works Ltd   (Hungary)

^c INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

Calmodulin antagonists; Circular dichroism spectroscopy; Fendiline analogue; Hydrophobic interactions; X ray diffraction

Indexed keywords

ARALKYLAMINE; CALCIUM ION; CALMODULIN; CALMODULIN INHIBITOR; N (3,3 DIPHENYLPROPYL) N' [1 (3,4 BIS BUTOXYPHENYL)ETHYL]PROPYLENEDIAMINE; PHOSPHODIESTERASE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENTROPY; ENZYME ACTIVITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; REACTION ANALYSIS; STOICHIOMETRY; STRUCTURE ANALYSIS;

EID: 0034737308     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3607     Document Type: Article

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