메뉴 건너뛰기




Volumn 408, Issue 3, 2006, Pages 214-219

Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder

Author keywords

Association study; Borderline personality disorder; Candidate gene; Genetics; Personality trait; Serotonin 2A receptor gene

Indexed keywords

SEROTONIN 2A RECEPTOR;

EID: 33749508987     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.09.002     Document Type: Article
Times cited : (52)

References (58)
  • 1
    • 0042121277 scopus 로고    scopus 로고
    • A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior
    • Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol. Psychiatry 8 (2003) 646-653
    • (2003) Mol. Psychiatry , vol.8 , pp. 646-653
    • Anguelova, M.1    Benkelfat, C.2    Turecki, G.3
  • 2
    • 0035490583 scopus 로고    scopus 로고
    • Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association
    • APA. Practice guideline for the treatment of patients with borderline personality disorder. American Psychiatric Association. Am. J. Psychiatry 158 (2001) 1-52
    • (2001) Am. J. Psychiatry , vol.158 , pp. 1-52
    • APA1
  • 3
    • 0025149638 scopus 로고
    • Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims
    • Arango V., Ernsberger P., Marzuk P.M., Chen J.S., Tierney H., Stanley M., Reis D.J., and Mann J.J. Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Arch. Gen. Psychiatry 47 (1990) 1038-1047
    • (1990) Arch. Gen. Psychiatry , vol.47 , pp. 1038-1047
    • Arango, V.1    Ernsberger, P.2    Marzuk, P.M.3    Chen, J.S.4    Tierney, H.5    Stanley, M.6    Reis, D.J.7    Mann, J.J.8
  • 4
    • 0003112316 scopus 로고    scopus 로고
    • Serotonin chemistry in the brain of suicide victims
    • Mans R., Silverman M., and Canetto S. (Eds), Guilford Press, New York
    • Arango V., and Underwood M.D. Serotonin chemistry in the brain of suicide victims. In: Mans R., Silverman M., and Canetto S. (Eds). Review of Suicidology (1997), Guilford Press, New York
    • (1997) Review of Suicidology
    • Arango, V.1    Underwood, M.D.2
  • 5
    • 4043174258 scopus 로고    scopus 로고
    • Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
    • Assal F., Alarcon M., Solomon E.C., Masterman D., Geschwind D.H., and Cummings J.L. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch. Neurol. 61 (2004) 1249-1253
    • (2004) Arch. Neurol. , vol.61 , pp. 1249-1253
    • Assal, F.1    Alarcon, M.2    Solomon, E.C.3    Masterman, D.4    Geschwind, D.H.5    Cummings, J.L.6
  • 7
    • 0842286644 scopus 로고    scopus 로고
    • The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain
    • Bray N.J., Buckland P.R., Hall H., Owen M.J., and O'Donovan M.C. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Mol. Psychiatry 9 (2004) 109-114
    • (2004) Mol. Psychiatry , vol.9 , pp. 109-114
    • Bray, N.J.1    Buckland, P.R.2    Hall, H.3    Owen, M.J.4    O'Donovan, M.C.5
  • 9
    • 0025641667 scopus 로고
    • Personality disorders and the five-factor model of personality
    • Costa P.T., and McCrae R.R. Personality disorders and the five-factor model of personality. J. Personal Disord. 4 (1990) 362-371
    • (1990) J. Personal Disord. , vol.4 , pp. 362-371
    • Costa, P.T.1    McCrae, R.R.2
  • 10
  • 11
    • 0034615109 scopus 로고    scopus 로고
    • Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
    • Du L., Bakish D., Lapierre Y.D., Ravindran A.V., and Hrdina P.D. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am. J. Med. Genet. 96 (2000) 56-60
    • (2000) Am. J. Med. Genet. , vol.96 , pp. 56-60
    • Du, L.1    Bakish, D.2    Lapierre, Y.D.3    Ravindran, A.V.4    Hrdina, P.D.5
  • 13
    • 0041857847 scopus 로고    scopus 로고
    • Pedigree disequilibrium tests for multilocus haplotypes
    • Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 (2003) 115-121
    • (2003) Genet. Epidemiol. , vol.25 , pp. 115-121
    • Dudbridge, F.1
  • 14
    • 3242774471 scopus 로고    scopus 로고
    • Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims
    • Escriba P.V., Ozaita A., and Garcia-Sevilla J.A. Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. Neuropsychopharmacology 29 (2004) 1512-1521
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1512-1521
    • Escriba, P.V.1    Ozaita, A.2    Garcia-Sevilla, J.A.3
  • 18
    • 0027178051 scopus 로고
    • 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala
    • Hrdina P.D., Demeter E., Vu T.B., Sotonyi P., and Palkovits M. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain Res. 614 (1993) 37-44
    • (1993) Brain Res. , vol.614 , pp. 37-44
    • Hrdina, P.D.1    Demeter, E.2    Vu, T.B.3    Sotonyi, P.4    Palkovits, M.5
  • 19
    • 0035169677 scopus 로고    scopus 로고
    • Levels of serotonin receptor 2A higher in suicide victims?
    • Hrdina P.D., and Du L. Levels of serotonin receptor 2A higher in suicide victims?. Am. J. Psychiatry 158 (2001) 147-148
    • (2001) Am. J. Psychiatry , vol.158 , pp. 147-148
    • Hrdina, P.D.1    Du, L.2
  • 20
    • 0027992234 scopus 로고
    • Glutamatergic control of dopamine release during stress in the rat prefrontal cortex
    • Jedema H.P., and Moghaddam B. Glutamatergic control of dopamine release during stress in the rat prefrontal cortex. J. Neurochem. 63 (1994) 785-788
    • (1994) J. Neurochem. , vol.63 , pp. 785-788
    • Jedema, H.P.1    Moghaddam, B.2
  • 22
    • 0031582414 scopus 로고    scopus 로고
    • 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia
    • Kouzmenko A.P., Hayes W.L., Pereira A.M., Dean B., Burnet P.W., and Harrison P.J. 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia. Lancet 349 (1997) 1815
    • (1997) Lancet , vol.349 , pp. 1815
    • Kouzmenko, A.P.1    Hayes, W.L.2    Pereira, A.M.3    Dean, B.4    Burnet, P.W.5    Harrison, P.J.6
  • 23
    • 0033031019 scopus 로고    scopus 로고
    • No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia
    • Kouzmenko A.P., Scaffidi A., Pereira A.M., Hayes W.L., Copolov D.L., and Dean B. No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia. Hum. Hered. 49 (1999) 103-105
    • (1999) Hum. Hered. , vol.49 , pp. 103-105
    • Kouzmenko, A.P.1    Scaffidi, A.2    Pereira, A.M.3    Hayes, W.L.4    Copolov, D.L.5    Dean, B.6
  • 24
    • 3042855136 scopus 로고    scopus 로고
    • 5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease
    • Lam L.C., Tang N.L., Ma S.L., Zhang W., and Chiu H.F. 5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease. Int. J. Geriatr. Psychiatry 19 (2004) 523-526
    • (2004) Int. J. Geriatr. Psychiatry , vol.19 , pp. 523-526
    • Lam, L.C.1    Tang, N.L.2    Ma, S.L.3    Zhang, W.4    Chiu, H.F.5
  • 26
    • 0036734874 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressant and mood-stabilizing drugs: a review of candidate-gene studies and future research directions
    • Lerer B., and Macciardi F. Pharmacogenetics of antidepressant and mood-stabilizing drugs: a review of candidate-gene studies and future research directions. Int. J. Neuropsychopharmacol. 5 (2002) 255-275
    • (2002) Int. J. Neuropsychopharmacol. , vol.5 , pp. 255-275
    • Lerer, B.1    Macciardi, F.2
  • 28
    • 0022930193 scopus 로고
    • Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims
    • Mann J.J., Stanley M., McBride P.A., and McEwen B.S. Increased serotonin2 and beta-adrenergic receptor binding in the frontal cortices of suicide victims. Arch. Gen. Psychiatry 43 (1986) 954-959
    • (1986) Arch. Gen. Psychiatry , vol.43 , pp. 954-959
    • Mann, J.J.1    Stanley, M.2    McBride, P.A.3    McEwen, B.S.4
  • 29
    • 0032402426 scopus 로고    scopus 로고
    • The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis
    • Marek G.J., and Aghajanian G.K. The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis. Biol. Psychiatry 44 (1998) 1118-1127
    • (1998) Biol. Psychiatry , vol.44 , pp. 1118-1127
    • Marek, G.J.1    Aghajanian, G.K.2
  • 30
    • 0033981186 scopus 로고    scopus 로고
    • Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex
    • Marek G.J., Wright R.A., Schoepp D.D., Monn J.A., and Aghajanian G.K. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. J. Pharmacol. Exp. Ther. 292 (2000) 76-87
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 76-87
    • Marek, G.J.1    Wright, R.A.2    Schoepp, D.D.3    Monn, J.A.4    Aghajanian, G.K.5
  • 32
    • 0029860939 scopus 로고    scopus 로고
    • Rapid reverse transcription-PCR detection of hepatitis C virus RNA in serum by using the TaqMan fluorogenic detection system
    • Morris T., Robertson B., and Gallagher M. Rapid reverse transcription-PCR detection of hepatitis C virus RNA in serum by using the TaqMan fluorogenic detection system. J. Clin. Microbiol. 34 (1996) 2933-2936
    • (1996) J. Clin. Microbiol. , vol.34 , pp. 2933-2936
    • Morris, T.1    Robertson, B.2    Gallagher, M.3
  • 33
    • 0038777244 scopus 로고    scopus 로고
    • Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder
    • Ni X., Trakalo J.M., Mundo E., Lee L., Parikh S., and Kennedy J.L. Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder. Neuromol. Med. 2 (2002) 251-259
    • (2002) Neuromol. Med. , vol.2 , pp. 251-259
    • Ni, X.1    Trakalo, J.M.2    Mundo, E.3    Lee, L.4    Parikh, S.5    Kennedy, J.L.6
  • 34
    • 0028436350 scopus 로고
    • Genetics of personality disorders: perspectives from personality and psychopathology research
    • Nigg J.T., and Goldsmith H.H. Genetics of personality disorders: perspectives from personality and psychopathology research. Psychol. Bull. 115 (1994) 346-380
    • (1994) Psychol. Bull. , vol.115 , pp. 346-380
    • Nigg, J.T.1    Goldsmith, H.H.2
  • 35
    • 0035878558 scopus 로고    scopus 로고
    • Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients
    • Nishiguchi N., Matsushita S., Suzuki K., Murayama M., Shirakawa O., and Higuchi S. Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients. Biol. Psychiatry 50 (2001) 123-128
    • (2001) Biol. Psychiatry , vol.50 , pp. 123-128
    • Nishiguchi, N.1    Matsushita, S.2    Suzuki, K.3    Murayama, M.4    Shirakawa, O.5    Higuchi, S.6
  • 36
    • 17844377615 scopus 로고    scopus 로고
    • HTR2A: association and expression studies in neuropsychiatric genetics
    • Norton N., and Owen M.J. HTR2A: association and expression studies in neuropsychiatric genetics. Ann. Med. 37 (2005) 121-129
    • (2005) Ann. Med. , vol.37 , pp. 121-129
    • Norton, N.1    Owen, M.J.2
  • 38
  • 39
    • 0030911906 scopus 로고    scopus 로고
    • A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization
    • Ozaki N., Manji H., Lubierman V., Lu S.J., Lappalainen J., Rosenthal N.E., and Goldman D. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. J. Neurochem. 68 (1997) 2186-2193
    • (1997) J. Neurochem. , vol.68 , pp. 2186-2193
    • Ozaki, N.1    Manji, H.2    Lubierman, V.3    Lu, S.J.4    Lappalainen, J.5    Rosenthal, N.E.6    Goldman, D.7
  • 40
    • 0030589453 scopus 로고    scopus 로고
    • Two naturally occurring amino acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls
    • Ozaki N., Rosenthal N.E., Pesonen U., Lappalainen J., Feldman-Naim S., Schwartz P.J., Turner E.H., and Goldman D. Two naturally occurring amino acid substitutions of the 5-HT2A receptor: similar prevalence in patients with seasonal affective disorder and controls. Biol. Psychiatry 40 (1996) 1267-1272
    • (1996) Biol. Psychiatry , vol.40 , pp. 1267-1272
    • Ozaki, N.1    Rosenthal, N.E.2    Pesonen, U.3    Lappalainen, J.4    Feldman-Naim, S.5    Schwartz, P.J.6    Turner, E.H.7    Goldman, D.8
  • 41
    • 0031590705 scopus 로고    scopus 로고
    • Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies
    • Pandey G.N. Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies. Ann. N.Y. Acad. Sci. 836 (1997) 182-200
    • (1997) Ann. N.Y. Acad. Sci. , vol.836 , pp. 182-200
    • Pandey, G.N.1
  • 42
    • 0037086178 scopus 로고    scopus 로고
    • Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics
    • Polesskaya O.O., and Sokolov B.P. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J. Neurosci. Res. 67 (2002) 812-822
    • (2002) J. Neurosci. Res. , vol.67 , pp. 812-822
    • Polesskaya, O.O.1    Sokolov, B.P.2
  • 43
    • 30544435620 scopus 로고    scopus 로고
    • Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors
    • Popa D., Lena C., Fabre V., Prenat C., Gingrich J., Escourrou P., Hamon M., and Adrien J. Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J. Neurosci. 25 (2005) 11231-11238
    • (2005) J. Neurosci. , vol.25 , pp. 11231-11238
    • Popa, D.1    Lena, C.2    Fabre, V.3    Prenat, C.4    Gingrich, J.5    Escourrou, P.6    Hamon, M.7    Adrien, J.8
  • 44
    • 0034606210 scopus 로고    scopus 로고
    • No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependents
    • Preuss U.W., Koller G., Bahlmann M., Soyka M., and Bondy B. No association between suicidal behavior and 5-HT2A-T102C polymorphism in alcohol dependents. Am. J. Med. Genet. 96 (2000) 877-878
    • (2000) Am. J. Med. Genet. , vol.96 , pp. 877-878
    • Preuss, U.W.1    Koller, G.2    Bahlmann, M.3    Soyka, M.4    Bondy, B.5
  • 45
    • 0035068793 scopus 로고    scopus 로고
    • Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders
    • Preuss U.W., Koller G., Bondy B., Bahlmann M., and Soyka M. Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. Neuropsychobiology 43 (2001) 186-191
    • (2001) Neuropsychobiology , vol.43 , pp. 186-191
    • Preuss, U.W.1    Koller, G.2    Bondy, B.3    Bahlmann, M.4    Soyka, M.5
  • 46
    • 0037093914 scopus 로고    scopus 로고
    • Family history of suicide and neuroticism: a preliminary study
    • Roy A. Family history of suicide and neuroticism: a preliminary study. Psychiatry Res. 110 (2002) 87-90
    • (2002) Psychiatry Res. , vol.110 , pp. 87-90
    • Roy, A.1
  • 47
    • 32844469622 scopus 로고    scopus 로고
    • The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study
    • Rybakowski F., Slopien A., Dmitrzak-Weglarz M., Czerski P., Rajewski A., and Hauser J. The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study. Neuropsychobiology 53 (2006) 33-39
    • (2006) Neuropsychobiology , vol.53 , pp. 33-39
    • Rybakowski, F.1    Slopien, A.2    Dmitrzak-Weglarz, M.3    Czerski, P.4    Rajewski, A.5    Hauser, J.6
  • 48
    • 33744492043 scopus 로고    scopus 로고
    • Trends in suicidology: personality as an endophenotype for molecular genetic investigations
    • Savitz J.B., Cupido C.L., and Ramesar R.S. Trends in suicidology: personality as an endophenotype for molecular genetic investigations. PLoS Med. 3 (2006) e107
    • (2006) PLoS Med. , vol.3
    • Savitz, J.B.1    Cupido, C.L.2    Ramesar, R.S.3
  • 50
    • 0034027933 scopus 로고    scopus 로고
    • Association of aggressive behavior with altered serotonergic function in patients who are not suicidal
    • Stanley B., Molcho A., Stanley M., Winchel R., Gameroff M.J., Parsons B., and Mann J.J. Association of aggressive behavior with altered serotonergic function in patients who are not suicidal. Am. J. Psychiatry 157 (2000) 609-614
    • (2000) Am. J. Psychiatry , vol.157 , pp. 609-614
    • Stanley, B.1    Molcho, A.2    Stanley, M.3    Winchel, R.4    Gameroff, M.J.5    Parsons, B.6    Mann, J.J.7
  • 51
    • 0020660428 scopus 로고
    • Increased serotonin-2 binding sites in frontal cortex of suicide victims
    • Stanley M., and Mann J.J. Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet 1 (1983) 214-216
    • (1983) Lancet , vol.1 , pp. 214-216
    • Stanley, M.1    Mann, J.J.2
  • 52
    • 0031712747 scopus 로고    scopus 로고
    • Glutamatergic regulation of basal and stimulus-activated dopamine release in the prefrontal cortex
    • Takahata R., and Moghaddam B. Glutamatergic regulation of basal and stimulus-activated dopamine release in the prefrontal cortex. J. Neurochem. 71 (1998) 1443-1449
    • (1998) J. Neurochem. , vol.71 , pp. 1443-1449
    • Takahata, R.1    Moghaddam, B.2
  • 55
    • 2442646476 scopus 로고    scopus 로고
    • Serotonergic and noradrenergic neurobiology of alcoholic suicide
    • Underwood M.D., Mann J.J., and Arango V. Serotonergic and noradrenergic neurobiology of alcoholic suicide. Alcohol Clin. Exp. Res. 28 (2004) 57S-69S
    • (2004) Alcohol Clin. Exp. Res. , vol.28
    • Underwood, M.D.1    Mann, J.J.2    Arango, V.3
  • 57
    • 0027300190 scopus 로고
    • An MspI polymorphism in the hyman serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis
    • Warren Jr. J.T., Peacock M.L., Rodriguez L.C., and Fink J.K. An MspI polymorphism in the hyman serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis. Hum. Mol. Genet. 2 (1993) 338
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 338
    • Warren Jr., J.T.1    Peacock, M.L.2    Rodriguez, L.C.3    Fink, J.K.4
  • 58
    • 2942692129 scopus 로고    scopus 로고
    • Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    • Winstanley C.A., Dalley J.W., Theobald D.E., and Robbins T.W. Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology 29 (2004) 1331-1343
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1331-1343
    • Winstanley, C.A.1    Dalley, J.W.2    Theobald, D.E.3    Robbins, T.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.