The proximal promoter region is essential for lipopolysaccharide induction and cyclic AMP inhibition of mouse tumor necrosis factor-α

Journal of Interferon and Cytokine Research

Volumn 22, Issue 5, 2002, Pages 539-548

  O'Donnell, Phyllis M ^a   Taffet, Steven M ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 BROMO CYCLIC AMP; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLIC AMP; HEMAGGLUTININ; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE CONSTRUCT; GENE DELETION; GENE INDUCTION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; REGULATOR GENE; REPORTER GENE;

ANIMAL; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CYCLIC AMP; GENE EXPRESSION REGULATION; GENES, REGULATOR; GENES, REPORTER; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SEQUENCE DELETION; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TUMOR NECROSIS FACTOR; ANIMALS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); FELIS CATUS; MURINAE;

EID: 0036016552     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/10799900252982016     Document Type: Article

References (45)

1. Role of cytokines in sepsis
2. Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure
3. The role of tumor necrosis factor in the pathophysiology of heart failure
4. Tumor necrosis factor in congestive heart failure: A mechanism of disease for the new millennium?
5. Tumor necrosis factor alpha and interleukin 1 beta in synovial fluid of infants and children with suppurative arthritis
6. Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
7. TNF inhibitors in the treatment of arthritis
8. Anti-TNF alpha therapy is useful in rheumatoid arthritis and Crohn's disease: Analysis of the mechanism of action predicts utility in other diseases
9. Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)
10. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
11. Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: Differential effects on production and allele frequencies
12. Relative contribution of transcription and translation to the induction of tumor necrosis factor-a by lipopolysaccharide
13. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
14. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages
15. The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines
16. A Sp1 binding site of the tumor necrosis factor alpha promoter functions as a nitric oxide response element
17. Regulation of the human TNF promoter by the transcription factor Ets
18. Cell type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/JUN
19. TNF-alpha gene expression in macrophages: Regulation by NF-kappa B is independent of c-Jun or C/EBP beta
20. Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide
21. Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines
22. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors
23. ETS1, NFkappaB and AP1 synergistically transactivate the human GM-CSF promoter
24. Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP
25. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
26. Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP
27. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha
28. 2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: Distinct targeting in the signaling pathways
29. 2 and cyclic nucleotides
30. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor alpha transcriptional activation by regulating nuclear factor-κB and cAMP response element-binding protein/c-Jun
31. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes
32. Regulation of NF-kappa B activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester
33. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
34. A simple and rapid method for the selection of oligodeoxynucleotide-directed mutants
35. Ets transcription factors regulate an enhancer activity in the third intron of TNF-alpha
36. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
37. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo
38. Transcriptional regulation by cyclic AMP
39. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
40. Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene
41. Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: Lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent
42. A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression
43. Stimulus-specific assembly of enhancer complexes on the tumor necrosis factor alpha gene promoter
44. Cell cycle regulation of the transcriptional coactivators p300 and CREB binding protein
45. Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells