Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin-producing fibroblasts

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 4, 2006, Pages

  Plotkin, Matthew D ^a   Goligorsky, Michael S ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Fibroblast

Indexed keywords

ERYTHROPOIETIN; MATRIGEL; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL ISOLATION; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE EXPRESSION; KIDNEY INTERSTITIUM; KIDNEY ISCHEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION;

EID: 33749418694     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00396.2005     Document Type: Article

References (39)

1. Abrahamson DR, Robert B, Hyink DP, St John PL, and Daniel TO. Origins and formation of microvasculature in the developing kidney. Kidney Int Suppl 67: S7-S11, 1998.
2. Alcorn D, Maric C, and McCausland J. Development of the renal interstitium. Pediatr Nephrol 13: 347-354, 1999.
3. Baksh D, Song L, and Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8: 301-316, 2004.
4. Claffey KP, Abrams K, Shih SC, Brown LF, Mullen A, and Keough M. Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis. Lab Invest 81: 61-75, 2001.
5. Cullen-McEwen LA, Caruana G, and Bertram JF. The where, what and why of the developing renal stroma. Nephron Exp Nephrol 99: e1-e8, 2005.
6. Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, and Bonventre JV. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 115: 1743-1755, 2005.
7. Gardner L, Li F, Yang X, and Dang C. Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a. Mol Biol Cell 23: 9032-9045, 2003.
8. Goldberg MA, Glass GA, Cunningham JM, and Bunn HF. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 84: 7972-7976, 1987.
9. Hahn AW, Kern F, Jonas U, John M, Buhler FR, and Resink TJ. Functional aspects of vascular tenascin-C expression. J Vasc Res 32:162-174, 1995.
10. Hatini V, Huh SO, Herzlinger D, Soares VC, and Lai E. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev 10: 1467-1478, 1996.
11. Hay ED. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn 233: 706-720, 2005.
12. Herzlinger D. Renal interstitial fibrosis: remembrance of things past? J Clin Invest 110: 305-306, 2002.
13. Huez I, Bornes S, Bresson D, Creancier L, and Prats H. New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation. Mol Endocrinol 15: 2197-2210, 2001.
14. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, and Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002.
15. Jones PL and Jones FS. Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19: 581-596, 2000.
16. Karavanova ID, Dove LF, Resau JH, and Perantoni AO. Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme. Development 122: 4159-4167, 1996.
17. Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S, and Epstein SE. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94: 678-685, 2004.
18. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, Fuchs S, and Epstein SE. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109: 1543-1549, 2004.
19. Kraal G, Rep M, and Janse M. Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. An immunohistochemical study. Scand J Immunol 26: 653-661, 1987.
20. Levinson R and Mendelsohn C. Stromal progenitors are important for patterning epithelial and mesenchymal cell types in the embryonic kidney. Semin Cell Dev Biol 14: 225-231, 2003.
21. Lucas PA, Calcutt AF, Southerland SS, Wilson JA, Harvey RL, Warejcka D, and Young HE. A population of cells resident within embryonic and newborn rat skeletal muscle is capable of differentiating into multiple mesodermal phenotypes. Wound Repair Regen 3: 449-460, 1995.
22. Maxwell PH, Ferguson DJ, Nicholls LG, Johnson MH, and Ratcliffe PJ. The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. Kidney Int 52: 715-724, 1997.
23. Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, and Ratcliffe PJ. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 44: 1149-1162, 1993.
24. Miyazaki Y, Oshima K, Fogo A, and Ichikawa I. Evidence that bone morphogenic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int 63: 835-844, 2003.
25. Montesano R, Schaller G, and Orci L. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell 66: 697-711, 1991.
26. Motoike T, Loughna S, Perens E, Roman BL, Liao W, Chau TC, Richardson CD, Kawate T, Kuno J, Weinstein BM, Stainier DY, and Sato TN. Universal GFP reporter for the study of vascular development. Genesis 28: 75-81, 2000.
27. Passaniti A, Taylor RM, Pili R, Guo Y, Long PV, Haney JA, Pauly RR, Grant DS, and Martin GR. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 67: 519-528, 1992.
28. Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF, and Prockop DJ. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 103: 1662-1668, 2004.
29. Pillebout E, Burtin M, Yuan HT, Briand P, Woolf AS, Friedlander G, and Terzi F. Proliferation and remodeling of the peritubular microcirculation after nephron reduction: association with the progression of renal lesions. Am J Pathol 159: 547-560, 2001.
30. Pola R, Ling LE, Silver M, Corbley MJ, Kearney M, Blake Pepinsky R, Shapiro R, Taylor FR, Baker DP, Asahara T, and Isner JM. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7: 706-711, 2001.
31. Quaggin SE, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, and Rossant J. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development 126: 5771-5783, 1999.
32. Rosenberger C, Griethe W, Gruber G, Wiesener M, Frei U, Bachmann S, and Eckardt KU. Cellular responses to hypoxia after renal segmental infarction. Kidney Int 64: 874-886, 2003.
33. Sabatini F, Petecchia L, Tavian M, de Villeroche VJ, Rossi GA, and Brouty-Boye D. Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities. Lab Invest 85: 962-971, 2005.
34. Sherwood JB and Shouval D. Continuous production of erythropoietin by an established human renal carcinoma cell line: development of the cell line. Proc Natl Acad Sci USA 83: 165-169, 1986.
35. Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D, Coulter SC, Lin J, Ober J, Vaughn WK, Branco RV, Oliveira EM, He R, Geng YJ, Willerson JT, and Perin EC. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 111: 150-156, 2005.
36. Stolze I, Berchner-Pfannschmidt U, Freitag P, Wotzlaw C, Rossler J, Frede S, Acker H, and Fandrey J. Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 100: 2623-2628, 2002.
37. Sun DF, Fujigaki Y, Fujimoto T, Yonemura K, and Hishida A. Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats. Am J Pathol 157: 1321-1335, 2000.
38. Togel F, Hu Z, Weiss K, Isaac J, Lange C, and Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 289: F31-F42, 2005.
39. Young HE, Mancini ML, Wright RP, Smith JC, Black AC Jr, Reagan CR, and Lucas PA. Mesenchymal stem cells reside within the connective tissues of many organs. Dev Dyn 202: 137-144, 1995.