Effect of topical nipradilol on retinal microvascular leukocyte adhesion in diabetic rats

Ophthalmic Research

Volumn 38, Issue 5, 2006, Pages 270-273

  Ono, Ryuichiro ^a   Kakehashi, Akihiro ^a   Ito, Yuka ^a   Sugi, Norito ^a   Makino, Shinji ^a   Kobayashi, Eiji ^a   Hakamada, Yoji ^a   Takagi, Yasuhiro ^b   Kitazume, Yusuke ^b   Kawakami, Masanobu ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KOWA COMPANY LTD   (Japan)

Author keywords

Blocker; Acridine orange digital fluorography; Diabetes; Diabetic retinopathy; Nipradilol; Nitric oxide donor; Retinal leukostasis

Indexed keywords

ACRIDINE ORANGE; ANTIGLAUCOMA AGENT; GLUCOSE; NIPRADILOL; NITRIC OXIDE DONOR; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG EFFECT; FLUOROGRAPHY; GLUCOSE BLOOD LEVEL; LEUKOCYTE; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; LEUKOSTASIS; MICROCIRCULATION; NONHUMAN; OPTIC DISK; PRIORITY JOURNAL; RAT; RETINA ARTERY; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; SCANNING LASER OPHTHALMOSCOPY; STREPTOZOCIN DIABETES;

ADMINISTRATION, TOPICAL; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CELL ADHESION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; FLUORESCEIN ANGIOGRAPHY; LEUKOCYTE COUNT; LEUKOCYTES; LEUKOSTASIS; MICROCIRCULATION; NITRIC OXIDE; NITRIC OXIDE DONORS; OPHTHALMIC SOLUTIONS; PROPANOLAMINES; RATS; RATS, INBRED BN; RETINAL ARTERY;

EID: 33749358309     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095769     Document Type: Article

References (29)

1. Schmetterer L, Findl O, Fasching P, Ferber W, Strenn K, Breiteneder H, Adam H, Eichler HG, Wolzt M: Nitric oxide and ocular blood flow in patients with IDDM. Diabetes 1997;46:653-658.
2. Dorner GT, Garhofer G, Kiss B, Polska E, Polak K, Riva CE, Schmetterer L: Nitric oxide regulates retinal vascular tone in humans. Am J Physiol Heart Circ Physiol 203;285:H631-H636.
3. Nakazawa T, Tomita H, Yamaguchi K, Sato Y, Shimura M, Kuwahara S, Tamai M: Neuroprotective effect of nipradilol on axotomized rat retinal ganglion cells. Curr Eye Res 2002;24:114-122.
4. Kashiwagi K, Iizuka Y, Tsukahara S: Neuroprotective effects of nipradilol on purified cultured retinal ganglion cells. J Glaucoma 2002;11:231-238.
5. Schroder S, Palinski W, Schmid-Schonbein GW: Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol 1991;139:81-100.
6. Kubes P, Suzuki M, Granger DN: Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-4655.
7. Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, Aiello LP, Ogura Y, Adamis AP: Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 1999;96:10836-10841.
8. Kinoshita N, Kakehashi A, Inoda S, Itou Y, Kuroki M, Yasu T, Kawakami M, Kanazawa Y: Effective and selective prevention of retinal leukostasis in streptozotocin-induced diabetic rats using gliclazide. Diabetologia 2002;45:735-739.
9. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE: Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes 2003;52:829-837.
10. Nishiwaki H, Ogura Y, Kimura H, Kiryu J, Honda Y: Quantitative evaluation of leukocyte dynamics in retinal microcirculation. Invest Ophthalmol Vis Sci 1995;36:123-130.
11. Nishiwaki H, Ogura Y, Kimura H, Kiryu J, Miyamoto K, Matsuda N: Visualization and quantitative analysis of leukocyte dynamics in retinal microcirculation of rats. Invest Ophthalmol Vis Sci 1996;37:1341-1347.
12. Miyamoto K, Hiroshiba N, Tsujikawa A, Ogura Y: In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 1998;39:2190-2194.
13. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK, Yeo KT: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994;118:445-450.
14. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480-1487.
15. Tanaka Y, Katoh S, Hori S, Miura M, Yamashita H: Vascular endothelial growth factor in diabetic retinopathy. Lancet 1997;349:1520.
16. Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP: VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci 2001;42:2408-2413.
17. Ishida S, Yamashiro K, Usui T, Amano S, Ogura Y, Hida T, Oguchi Y: Significance of leukocytes in the regulation of retinal edema, ischemia, and angiogenesis. Nippon Ganka Gakkai Zasshi 2004;108:193-201.
18. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76:301-314.
19. Rosales C, Juliano RL: Signal transduction by cell adhesion receptors in leukocytes. Leukocyte Biol 1995;57:189-198.
20. Luscinskas FW, Lawler J: Integrins and dynamic regulators of vascular function. FASEB J 1994;8:929-938.
21. Hynes RO: Integrins: a family of cell surface receptors. Cell 1987;48:549-554.
22. McLeod DS, Lefer DJ, Merges C, Lutty GA: Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroids. Am J Pathol 1995;147:642-653.
23. Khan BV, Harrison DG, Olbrych MT, Alexander RW, Medford RM: Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA 1996;93:9114-9119.
24. Moore TC, Moore JE, Kaji Y, Frizzell N, Usui T, Poulaki V, Campbell IL, Stitt AW, Gardiner TA, Archer DB, Adamis AP: The role of advanced glycation end products in retinal microvascular leukostasis. Invest Ophthalmol Vis Sci 2003;44:4457-4464.
25. Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP: Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci 2000;41:1153-1158.
26. Kida T, Sugiyama T, Harino S, Kitanishi K, Ikeda T: The effect of nipradilol, an alpha-beta blocker, on retinal blood flow in healthy volunteers. Curr Eye Res 2001;23:128-132.
27. Mizuno K, Koide T, Yoshimura M, Araie M: Neuroprotective effect and intraocular penetration of nipradilol, a beta-blocker with nitric oxide donative action. Invest Ophthalmol Vis Sci 2001;42:688-694.
28. Geroski DH, Edelhauser HF: Drug delivery for posterior segment eye disease. Invest Ophthalmol Vis Sci 2000;41:961-964.
29. Geroski DH, Edelhauser HF: Transscleral drug delivery for posterior segment disease. Adv Drug Deliv Rev 2001;52:37-48.