Visualization and quantitative analysis of leukocyte dynamics in retinal microcirculation of rats

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 7, 1996, Pages 1341-1347

  Nishiwaki, Hirokazu ^a   Ogura, Yuichiro ^a   Kimura, Hideya ^a   Kiryu, Junichi ^a   Miyamoto, Kazuaki ^a   Matsuda, Naoko ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

acridine orange digital fluorography; blood flow; leukocyte rheology; preferential channel; scanning laser ophthalmoloscope

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW VELOCITY; CONTROLLED STUDY; FLUOROGRAPHY; LEUKOCYTE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA BLOOD FLOW;

ACRIDINE ORANGE; ANIMALS; BLOOD FLOW VELOCITY; CAPILLARIES; CELL MOVEMENT; FLUORESCEIN ANGIOGRAPHY; FLUORESCENT DYES; IMAGE PROCESSING, COMPUTER-ASSISTED; LEUKOCYTE COUNT; LEUKOCYTES; MICROCIRCULATION; OPHTHALMOSCOPES; OPHTHALMOSCOPY; RATS; RETINAL ARTERY; RETINAL VESSELS; RHEOLOGY;

EID: 0029936065     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Bagge U, Amundson B, Lauritzen C. White blood cell deformability and plugging of skeletal muscle capillaries in hemorrhagic shock. Acta Physiol Scand. 1980;180: 159-163.
2. Engler RL, Schmid-Schönbein GW, Pavelec RS. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol. 1983;111:98-111.
3. Schröder S, Palinski W, Schmid-Schönbein GW. Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol. 1991;139:81-100.
4. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res. 1991;69:1566-1574.
5. Granger DN. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol. 1988;255:H1269-H1275.
6. Barroso-Aranda J, Schmid-Schönbein GW. Transformation of neutrophils as indicator of irreversibility in hemorrhagic shock. Am J Physiol. 1987;257:H846-H852.
7. Schmid-Schönbein GW, Shih YY, Chien S. Morphometry of human leukocytes. Blood. 1980a;56:866-875.
8. Schmid-Schönbein GW, Sung KLP, Tözeren H, Skalak R, Chien S. Passive mechanical properties of human leukocytes. Biophys J. 1981;36:243-256.
9. Fantorle, JC, Ward PA. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol. 1982;107:397-418.
10. Nathan, CF, Murray HW, Cohn ZA. The macrophage as an effector cell. N Engl J Med. 1980;303:622-626.
11. Werb Z. How the macrophage regulates its extracellular environment. Am J Anat. 1983;166:237-256.
12. Harris AG, Skalak TC. Effects of leukocyte activation on capillary hemodynamics in skeletal muscle. Am J Physiol. 1993;264:H909-H916.
13. Hatchell DL, Wilson CA, Saloupis P. Neutrophils plug capillaries in acute experimental retinal ischemia. Microvasc Res. 1994;47:344-354.
14. Riva CE, Petrig BL. Retinal blood flow: Laser Doppler velocimetry and blue field simulation technique. In: Masters BR, ed. Noninvasive Techniques in Ophthalmology. New York: Springer-Verlag; 1990;400-409.
15. Fallon TJ, Chowiencyzk P, Kohner EM. Measurement of retinal blood flow in diabetes by the blue-light entoptic phenomenon. Br J Ophthalmol. 1986; 70:43-46.
16. Grunwald JE, Piltz J, Patel N, Bose S, Riva CE. Effect of aging on retinal macular microcirculation: A blue field simulation study. Invest Ophthalmol Vis Sci. 1993; 34:3609-3613.
17. Loebl M, Riva CE. Macular circulation and the flying corpuscles phenomenon. Ophthalmology. 1978;85: 911-917.
18. Tanaka T, Muraoka K, Shimizu K. Fluorescein fundus angiography with scanning laser ophthalmoscope: Visibility of leukocytes and platelets in perifoveal capillaries. Ophthalmology. 1991;98:1824-1829.
19. Ohnishi Y, Fujisawa K, Ishibashi T, Kojima H. Capillary blood flow velocity measurements in cystoid macular edema with the scanning laser ophthalmoscope. Am J Ophthalmol. 1994;117:24-29.
20. Arend O, Harris A, Wolf S. Capillary blood flow velocity measurements in cystoid macular edema with the scanning laser ophthalmoscope. Am J Ophthalmol. 1994;117:819-820. Letter.
21. Nasemann JE, Müller M. Scanning laser angiography. In: Nasemann JE, Burk ROW, eds. Scanning Laser Ophthalmoscope. Munich: Quintessenz Verlag; 1990:63-80.
22. Nishiwaki H, Ogura Y, Kimura H, Kiryu J, Honda Y. Quantitative evaluation of leukocyte dynamics in retinal microcirculation. Invest Ophthalmol Vis Sci. 1995; 36:123-130.
23. Darzynkiewicz Z, Kapuscinski J. Acridine orange: A versatile probe of nucleic acids and other cell constituents. In: Melamed MR, ed. Flow Cytometry and Sorting. 2nd ed. New York: Wiley-Liss; 1990:291-314.
24. Amagasa J. Mechanisms of photodynamic inactivation of acridine orange-sensitized transfer RNA: Participation of single oxygen and base damage leading to inactivation. J Radiat Res. 1986;27:339-351.
25. Amagasa J. Binding of acridine orange to transfer RNA and photodynamic inactivation. J Radiat Res. 1986;27:325-338.
26. Gaehtgens P, Ley K, Pries AR, Müller R. Mutual interaction between leukocytes and microvascular blood flow. Prog Appl Microcirc. 1985;7:15-28.
27. Schmid-Schönbein GW, Skalak R, Simon SI, Engler R. The interaction between leukocytes and endothelium in vivo. Ann NY Acad Sci. 1987;516:348-361.
28. Bagge U, Karlsson R. Maintenance of white blood cell margination at the passage through small venular junctions. Microvasc Res. 1980;20:92-95.
29. Hallenbeck JH, Dutka AJ, Tanishima T, et al. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke. 1986;17:246-253.
30. Wilson JW. Leukocyte sequestration and morphologic augmentation in the pulmonary network following hemorrhagic shock and related forms of stress. Adv Microcirc. 1972;4:197-232.
31. Braide M, Blixt A, Bagge U. Leukocyte effects on the vascular resistance and glomerular filtration of the isolated rat kidney at normal and low flow states. Circulatory Shock. 1986;20:71-80.
32. Koo A, Liang IYS. Blood flow in hepatic sinusoids in experimental hemorrhagic shock in the rat. Microvasc Res. 1977;13:315-325.
33. Kloner RA, Ellis SG, Lange R, Braunwald E. Studies of experimental coronary artery reperfusion: Effects on infarct size, myocardial function, biochemistry, ultrastructure and microvascular damage. Circulation. 1983;68(suppl 1):1-8-1-15.
34. Braunwald E, Kloner R. Myocardial reperfusion: A double edged sword? J Clin Invest. 1985;76:1713-1719.
35. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation. 1983;67:1016-1023.
36. Jolly SR, Kane WJ, Hook BG, Abrams GD, Kunkel SL, Lucchesi BR. Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion. Am Heart J. 1986;112:682-690.
37. Blixt A, Braide M, Myrhage R, Bagge U. Vital microscopic studies on the capillary distribution of leukocytes in the rat cremaster muscle. Int J Microcirc Clin Exp. 1987;6:273-286.
38. Ley K, Pries AR, Gaehtgens P. Preferential distribution of leukocytes in rat mesentery microvessel networks. Pflüegers Arch. 1988;412:93-100.
39. Mayrovitz HN, Rubin R. Leukocyte distribution to arteriolar branches: dependence on microvascular blood flow. Microvasc Res. 1985;29:282-294.
40. Schmid-Schönbein GW, Skalak R, Usami S, Chien S. Cell distribution in capillary networks. Microvasc Res. 1980;19:18-44.
41. Ley K, Meyer J-U, Intaglietta M, Arfors K-E. Shunting of leukocytes in rabbit tenuissimus muscle. Am J Physiol. 1989;256:H85-H93.
42. Gaehtgens P. Pathways and interactions of white cells in the microcirculation. Prog Appl Microcirc. 1987;12:51-66.