Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: Function of alkyl chain length on opioid activity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 22, 2006, Pages 5793-5796

  Shiotani, Kimitaka ^a   Li, Tingyou ^a   Miyazaki, Anna ^a   Tsuda, Yuko ^a   Bryant, Sharon D ^b   Ambo, Akihiro ^c   Sasaki, Yusuke ^c   Lazarus, Lawrence H ^b   Okada, Yoshio ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Selective opioid ligand; 2 ,6 Dimethyl l tyrosine; Pyrazinone

Indexed keywords

MORPHINE; MU OPIATE RECEPTOR; PYRAZINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; MODELS, CHEMICAL; NARCOTIC ANTAGONISTS; PYRAZINES; RATS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; TYROSINE;

EID: 33749259430     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.079     Document Type: Article

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