Ethical problems in pharmacogenetic studies of psychiatric disorders

Pharmacogenomics Journal

Volumn 6, Issue 5, 2006, Pages 289-295

  Serretti, A ^a   Artioli, P ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PSYCHOTROPIC AGENT;

ACCESS TO INFORMATION; ARTICLE; BENEFICENCE; BLOOD SAMPLING; CLINICAL PROTOCOL; COMPETENCE; COST BENEFIT ANALYSIS; COUNSELING; DECISION MAKING; DEPRESSION; DISORIENTATION; DNA EXTRACTION; DOCTOR PATIENT RELATION; DRUG EFFICACY; DRUG SURVEILLANCE PROGRAM; EMOTIONAL DISORDER; GENE THERAPY; GENETIC SCREENING; GENOTYPE; HEALTH CARE COST; HUMAN; HUMAN RIGHTS; INFORMED CONSENT; JUSTICE; MEDICAL CARE; MENTAL DISEASE; MENTAL HEALTH; PATIENT INFORMATION; PATIENT PARTICIPATION; PHARMACOGENETICS; PRIORITY JOURNAL; PROFESSIONAL SECRECY; RELATIVE; RESEARCH ETHICS; RISK ASSESSMENT; SAMPLE; STORAGE; SYMPTOMATOLOGY; TREATMENT OUTCOME; WRITING;

ANTIPSYCHOTIC AGENTS; BENEFICENCE; CLINICAL TRIALS; CLINICAL TRIALS AS TOPIC; GENETIC PRIVACY; GENOTYPE; HUMANS; INFORMED CONSENT; MENTAL COMPETENCY; MENTAL DISORDERS; PHARMACOGENETICS; PHYSICIAN-PATIENT RELATIONS; PSYCHIATRY;

EID: 33749255328     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500388     Document Type: Article

References (59)

1. Malhotra AK, Murphy Jr GM, Kennedy JL. Pharmacogenetics of psychotropic drug response. Am J Psychiatry 2004; 161: 780-796.
2. Serretti A, Artioli P. From molecular biology to pharmacogenetics: A review of the literature on antidepressant treatment and suggestions of possible candidate genes. Psychopharmacology 2004; 174: 490-503.
3. Arranz M, Mancama D, Staddon S, Clark D, Parsons M, Mata I et al. Advances in the pharmacogenetic prediction of response to atypical antipsychotics. Pharmacogenetics, In Psychiatry Meeting 2003, New York: Green tab.
4. Kawanishi Y, Tachikawa H, Suzuki T. Pharmacogenomics and schizophrenia. Eur J Pharmacol 2000; 410: 227-241.
5. Waterwort DM, Bassett AS, Brzustowicz LM. Recent advances in the genetics of schizophrenia. Cell Mol Life Sci 2002; 59: 331-348.
6. Anonymous. The nuremberg code. JAMA 1996; 276: 1691.
7. CavalliSforza L. The History and Geography of Human Genes. Princeton University Press: Princeton, New Jersey, USA, 1994.
8. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn, American Psychiatric Association: Washington DC, 1994.
9. American Psychiatric Association. Practice guideline for the treatment of patients with schizophrenia. American Psychiatric Association. Am J Psychiatry 1997; 154: 1-63.
10. American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association. Am J Psychiatry 2000; 157: 1-45.
11. Osborn DP, Fulford KW. Psychiatric research: What ethical concerns do LRECs encounter? A postal survey. Local research ethics committees. J Med Ethics 2003; 29: 55-56.
12. Singh D. Ethical issues of pharmacogenetics must be addressed, says Nuffield Council. Bmj 2003; 327: 701.
13. Appelbaum PS, Andrews L, Zuiker ES, Basu A, Tsapakis E, Aitchison K et al. Ethical issues in psychiatric genetics ethical, legal, and social issues in genetic testing for complex genetic diseases pharmacogenetics and psychiatry using pharmacogenetics and pharmacogenomics in the treatment of psychiatric disorders: Some ethical and economic considerations ethical issues in psychiatric genetics research: Points to consider. J Psychiatr Pract 2004; 10: 343-351.
14. Andrews L, Zuiker ES, Basu A, Tsapakis E, Aitchison K. Ethical, legal, and social issues in genetic testing for complex genetic diseases Pharmacogenetics and psychiatry. Valparaiso Univ Law Rev 2003; 37: 793-829.
15. Basu A, Tsapakis E, Aitchison K. Pharmacogenetics and psychiatry. Curr Psychiatry Rep 2004; 6: 134-142.
16. Basu A, Tsapakis E, Aitchison K, Biesecker BB, Peay HL. Pharmacogenetics and psychiatry Ethical issues in psychiatric genetics research: Points to consider. Curr Psychiatry Rep 2004; 6: 134-142.
17. Appelbaum PS, Grisso T, Frank E, O'Donnell S, Kupfer DJ. Competence of depressed patients for consent to research. Am J Psychiatry 1999; 156: 1380-1384.
18. Grisso T, Appelbaum PS. Comparison of standards for assessing patients' capacities to make treatment decisions. Am J Psychiatry 1995; 152: 1033-1037.
19. Appelbaum PS, Grisso T. Assessing patients' capacities to consent to treatment. N Engl J Med 1988; 319: 1635-1638.
20. APA. Guidelines for assessing the decision-making capacities of potential research subjects with cognitive impairment. American Psychiatric Association. Am J Psychiatry 1998; 155: 1649-1650.
21. Sachs GA, Stocking CB, Stern R, Cox DM, Hougham G, Sachs RS. Ethical aspects of dementia research: Informed consent and proxy consent. Clin Res 1994; 42: 403-412.
22. Marson DC, Hawkins L, McInturff B, Harrell LE. Cognitive models that predict physician judgments of capacity to consent in mild Alzheimer's disease. J Am Geriatr Soc 1997; 45: 458-464.
23. Marson DC, McInturff B, Hawkins L, Bartolucci A, Harrell LE. Consistency of physician judgments of capacity to consent in mild Alzheimer's disease. J Am Geriatr Soc 1997; 45: 453-457.
24. Elliot C. Mentally disabled and mentally ill persons: Research issues. In: Reich WT (ed). Encyclopedia of Bioethics. Simon and Shuster: New York, 1995.
25. Faden RR, Beauchamp TL. A History and Theory of Informed Consent. Oxford University Press: Oxford, 1986.
26. Appelbaum PS. Rethinking the conduct of psychiatric research. Arch Gen Psychiatry 1997; 54: 117-120.
27. Cassel CK, Meier DE, Traines ML. Selected bibliography of recent articles in ethics and geriatrics. J Am Geriatr Soc 1986; 34: 399-409.
28. High DM, Doole MM. Ethical and legal issues in conducting research involving elderly subjects. Behav Sci Law 1995; 13: 319-335.
29. Savulescu J, Kerridge IH. Competence and consent. Med J Aust 2001; 175: 313-315.
30. Carpenter Jr WT, Gold JM, Lahti AC, Queern CA, Conley RR, Bartko JJ et al. Decisional capacity for informed consent in schizophrenia research. Arch Gen Psychiatry 2000; 57: 533-538.
31. Karlawish JH, Casarett D. Addressing the ethical challenges of clinical trials that involve patients with dementia. J Geriatr Psychiatry Neurol 2001; 14: 222-228.
32. Kim SY, Cox C, Caine ED. Impaired decision-making ability in subjects with Alzheimer's disease and willingness to participate in research. Am J Psychiatry 2002; 159: 797-802.
33. Saks ER, Dunn LB, Marshall BJ, Nayak GV, Golshan S, Jeste DV. The California Scale of Appreciation: A new instrument to measure the appreciation component of capacity to consent to research. Am J Geriatr Psychiatry 2002; 10: 166-174.
34. W.M.A. World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997; 277: 925-926.
35. Shapira A. The rules applying to scientific research. J Int Bioethique 2001; 12: 43-49.
36. McEwen JE, Reilly PR. A survey of DNA diagnostic laboratories regarding DNA banking. Am J Hum Genet 1995; 56: 1477-1486.
37. McEwen JE, Reilly PR. Stored Guthrie cards as DNA 'banks'. Am J Hum Genet 1994; 55: 196-200.
38. Emilien G, Ponchon M, Caldas C, Isacson O, Maloteaux JM. Impact of genomics on drug discovery and clinical medicine. Qjm 2000; 93: 391-423.
39. Fuller BP, Kahn MJ, Barr PA, Biesecker L, Crowley E, Garber J et al. Privacy in genetics research. Science 1999; 285: 1359-1361.
40. Botkin JR, McMahon WM, Smith KR, Nash JE. Privacy and confidentiality in the publication of pedigrees: A survey of investigators and biomedical journals. JAMA 1998; 279: 1808-1812.
41. Parker LS. Ethical issues in bipolar disorders pedigree research: privacy concerns, informed consent, and grounds for waiver. Bipolar Disord 2002; 4: 1-16.
42. Parker LS. Bioethics for human geneticists: Models for reasoning and methods for teaching. Am J Hum Genet 1994; 54: 137-147.
43. Nebert DW, Bingham E. Pharmacogenomics: Out of the lab and into the community. Trends Biotechnol 2001; 19: 519-523.
44. Anonymous. Proposed model federal policy for protection of human subjects; response to the First Biennial Report of the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Fed Regist 1986; 51: 20204-20217.
45. Leflar RB. The cautious acceptance of informed consent in Japan. Med Law 1997; 16: 705-720.
46. Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1997; 277: 301-306.
47. Persidis A. The business of pharmacogenomics. Nat Biotechnol 1998; 16: 209-210.
48. Kendler KS. 'A gene fory': The nature of gene action in psychiatric disorders. Am J Psychiatry 2005; 162: 1243-1252.
49. Serretti A, Calati R, Mandelli L, De Ronchi D. Serotonin transporter gene variants and behaviour: A comprehensive review. Current Drug Targets, in press.
50. Schulman KA, Linas BP. Pharmacoeconomics: State of the art in 1997. Annu Rev Public Health 1997; 18: 529-548.
51. Ameen M, Smith CH, Barker JN. Pharmacogenetics in clinical dermatology. Br J Dermatol 2002; 146: 2-6.
52. Anderson JL, Carlquist JF, Horne BD, Muhlestein JB. Cardiovascular pharmacogenomics: Current status, future prospects. J Cardiovasc Pharmacol Ther 2003; 8: 71-83.
53. Flexner CW. Advances in HIV pharmacology: Protein binding, pharmacogenomics, and therapeutic drug monitoring. Top HIV Med 2003; 11: 40-44.
54. Severino G, Chillotti C, Stochino ME, Del Zompo M. Pharmacogenomics: state of the research and perspectives in clinical application. Neurol Sci 2003; 24(Suppl 2): S146-S148.
55. Serretti A, Artioli P. Predicting response to lithium in mood disorders: role of genetic polymorphisms. Am J Pharmacogenomics 2003; 3: 17-30.
56. Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W. Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review. JAMA 2001; 286: 2270-2279.
57. Forster HP, Emanuel E, Grady C. The 2000 revision of the declaration of Helsinki: A step forward or more confusion? Lancet 2001; 358: 1449-1453.
58. Human D. Declaration of Helsinki. Lancet 2001; 357: 236.
59. Ramsay S. More developments in developing-world research ethics. Lancet 1999; 354: 1405-1406.