Rethinking the Conduct of Psychiatric Research

Archives of General Psychiatry

Volumn 54, Issue 2, 1997, Pages 117-120

  Appelbaum, Paul S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

BIOMEDICAL AND BEHAVIORAL RESEARCH; HUMAN; HUMAN EXPERIMENT; INFORMED CONSENT; MEDICAL ETHICS; MENTAL CAPACITY; MENTAL DISEASE; MENTAL HEALTH THERAPIES; METHODOLOGY; NOTE; PSYCHOLOGICAL ASPECT; STANDARD;

BIOMEDICAL AND BEHAVIORAL RESEARCH; MENTAL HEALTH THERAPIES;

ETHICS, MEDICAL; HUMAN EXPERIMENTATION; HUMANS; INFORMED CONSENT; MENTAL COMPETENCY; MENTAL DISORDERS; PLACEBOS; RESEARCH DESIGN;

EID: 0031068193     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1997.01830140025004     Document Type: Article

References (29)

1. Bonnie RJ. Research with cognitively impaired subjects: unfinished business in the regulation of human research. Arch Gen Psychiatry. 1997;54:105-111.
2. Elliott C. Caring about risks: are severely depressed patients competent to consent to research? Arch Gen Psychiatry. 1997;54:113-116.
3. Hassner V. What is ethical? what is not? where do you draw the line? J Calif Alliance Ment III. 1994;5(1):4-5.
4. Shamoo AE, Irving DN. Accountability in research using persons with mental illness. Accountability Res. 1993;3:1-17.
5. Advisory Committee on Human Radiation Experiments. Advisory Committee on Human Radiation Experiments: Final Report. Washington, DC: US Government Printing Office; October 1995.
6. Appelbaum PS, Roth LH. The structure of informed consent in psychiatric research. Behav Sci Law. 1983;1:9-19.
7. Appelbaum PS. Drug-free research in schizophrenia: an overview of the controversy. IRB Rev Hum Subjects Res. 1996;18(1):1-5.
8. Makuch RW, Johnson MF. Dilemmas in the use of active control groups in clinical research. IRB Rev Hum Subjects Res. 1989;11(1):1-5.
9. Office for Protection from Research Risks. Evaluation of Human Subject Protections in Schizophrenia Research Conducted by the University of California Los Angeles. Washington, DC: Office for Protection from Research Risks, National Institutes of Health; May 11, 1994.
10. KOatz J. Human experimentation and human rights. St Louis Univ Law J. 1993;38:7-54.
11. Clinical Center, National Institutes of Health. Colloquy in Research Ethics: Issues in Biomedical Research Involving Cognitively Impaired Subjects. Washington, DC: US Government Printing Office, National Institutes of Health; 1995.
12. GCrisso T, Appelbaum PS. The MacArthur Treatment Competence Study, III: abilities of patients to consent to psychiatric and medical treatments. Law Hum Behav. 1995;19:149-174.
13. Alloy LB, Abramson LY. Judgment of contingency in depressed and nondepressed students: sadder but wiser? J Exp Psychol. 1979;108:441-485.
14. Ackermann R, DeRubeis RJ. Is depressive realism real? Clin Psychol Rev. 1991;11:565-584.
15. Taylor SE. Positive Illusions: Creative Self-Deception and the Healthy Mind. New York, NY: Basic Books; 1989:211-226.
16. Hartlarge S, Alloy LB, Vazquez C, Dykman B. Automatic and effortful processing in depression. Psychol Bull. 1993;113:247-278.
17. Baker JE. Channon S. Reasoning in depression: impairment on a concept discrimination learning task. Cognition Emotion. 1995;9:579-597.
18. Morgado A, Smith M, Lecrubier Y, Widlocher D. Depressed subjects unwittingly overreport poor social adjustment which they reappraise when recovered. J Nerv Ment Dis. 1991;179:614-619.
19. Ganzini L, Lee Ma, Heintz RT, Bloom JD, Fenn DS. The effect of depression treatment on elderly patients' preferences for life-sustaining medical therapy. Am J Psychiatry. 1994;151:1631-1636.
20. Appelbaum PS, Grisso T. Assessing patients' capacities to consent to treatment. N Engl J Med. 1988;319:1635-1638.
21. Sullivan MD, Youngner SJ. Depression, competence and the right to refuse lifesaving medical treatment. Am J Psychiatry. 1994;151:971-978.
22. Bursztajn HJ, Harding HP, Gutheil TG, Brodsky A. Beyond cognition: the role of disordered affective states in impairing competence to consent to treatment. Bull Am Acad Psychiatry Law. 1991;19:383-388.
23. Bean G, Nishisato S, Rector N, Glancy G. The psychometric properties of the Competency Interview Schedule. Can J Psychiatry. 1994;39:368-376.
24. Roth LH, Lidz CW, Meisel A, Soloff PH, Kaufman K, Spiker DG, Foster FG. Competency to decide about treatment or research: an overview of some empirical data. Int J Law Psychiatry. 1982;5:29-50.
25. Appelbaum PS, Grisso T. The MacArthur Treatment Competence Study, I: mental illness and competence to consent to treatment. Law Hum Behav. 1995;19:105-126.
26. Berg JW, Appelbaum PS, Grisso T. Constructing competence: formulating standards of legal competence to make medical decisions. Rutgers Law Rev. 1996;48:345-396.
27. Appelbaum PS. Patients' competence to consent to neurobiological research. Accountability Res. 1996;4:241-251.
28. Benson PR, Roth LH, Appelbaum PS, Lidz CW, Winslade WJ. Information disclosure, subject understanding and informed consent in psychiatric research. Law Hum Behav. 1988;12:455-475.
29. President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Making Health Care Decisions: The Ethical and Legal Implications of Informed Consent in the Patient-Practitioner Relationship. Washington, DC: US Government Printing Office; 1982:2, 3.