메뉴 건너뛰기




Volumn 5, Issue 9, 2006, Pages 1681-1696

Optimal design of microarray immunoassays to compensate for kinetic limitations: Theory and experiment

Author keywords

[No Author keywords available]

Indexed keywords

ADSORPTION; ANTIBODY COMBINING SITE; ARTICLE; CHEMICAL REACTION KINETICS; DIFFUSION; DNA MICROARRAY; IMMUNOASSAY; INCUBATION TIME; MICROARRAY IMMUNOASSAY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN TRANSPORT; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO;

EID: 33749251322     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.T500035-MCP200     Document Type: Article
Times cited : (82)

References (53)
  • 1
    • 0036913652 scopus 로고    scopus 로고
    • Antibody microarrays: Promises and problems
    • Kusnezow, W., and Hoheisel, J. D. (2002) Antibody microarrays: promises and problems. BioTechniques (suppl.) 14-23
    • (2002) BioTechniques , Issue.SUPPL. , pp. 14-23
    • Kusnezow, W.1    Hoheisel, J.D.2
  • 2
    • 17844386055 scopus 로고    scopus 로고
    • Antibody arrays in cancer research
    • Haab, B. B. (2005) Antibody arrays in cancer research. Mol. Cell. Proteomics 4, 377-383
    • (2005) Mol. Cell. Proteomics , vol.4 , pp. 377-383
    • Haab, B.B.1
  • 3
    • 3142773316 scopus 로고    scopus 로고
    • Multiplexed sandwich assays in microarray format
    • Nielsen, U. B., and Geierstanger, B. H. (2004) Multiplexed sandwich assays in microarray format. J. Immunol. Methods 290, 107-120
    • (2004) J. Immunol. Methods , vol.290 , pp. 107-120
    • Nielsen, U.B.1    Geierstanger, B.H.2
  • 4
    • 0041627770 scopus 로고    scopus 로고
    • Solid supports for microarray immunoassays
    • Kusnezow, W., and Hoheisel, J. D. (2003) Solid supports for microarray immunoassays. J. Mol. Recognit. 16, 165-176
    • (2003) J. Mol. Recognit. , vol.16 , pp. 165-176
    • Kusnezow, W.1    Hoheisel, J.D.2
  • 5
    • 32944464394 scopus 로고    scopus 로고
    • Solid support for protein microarrays and related devices
    • in (Schena, M., ed) Jones and Bartlett Publishers, Sudbury, MA
    • Kusnezow, W., Pulli, T., Witt, O., and Hoheisel, J. D. (2004) Solid support for protein microarrays and related devices, in Protein Microarrays (Schena, M., ed) pp. 247-284, Jones and Bartlett Publishers, Sudbury, MA
    • (2004) Protein Microarrays , pp. 247-284
    • Kusnezow, W.1    Pulli, T.2    Witt, O.3    Hoheisel, J.D.4
  • 6
    • 2042468821 scopus 로고    scopus 로고
    • Advances in recombinant antibody microarrays
    • Pavlickova, P., Schneider, E. M., and Hug, H. (2004) Advances in recombinant antibody microarrays. Clin. Chim. Acta 343, 17-35
    • (2004) Clin. Chim. Acta , vol.343 , pp. 17-35
    • Pavlickova, P.1    Schneider, E.M.2    Hug, H.3
  • 7
    • 17044405183 scopus 로고    scopus 로고
    • Progress in protein and antibody microarray technology
    • Angenendt, P. (2005) Progress in protein and antibody microarray technology. Drug Discov. Today 10, 503-511
    • (2005) Drug Discov. Today , vol.10 , pp. 503-511
    • Angenendt, P.1
  • 8
    • 0036898579 scopus 로고    scopus 로고
    • Protein microarrays and proteomics
    • MacBeath, G. (2002) Protein microarrays and proteomics. Nat. Genet 32, (suppl.) 526-532
    • (2002) Nat. Genet , vol.32 , Issue.SUPPL. , pp. 526-532
    • MacBeath, G.1
  • 10
    • 4644229761 scopus 로고    scopus 로고
    • Evaluating sandwich immunoassays in microarray format in terms of the ambient analyte regime
    • Saviranta, P., Okon, R., Brinker, A., Warashina, M., Eppinger, J., and Geierstanger, B. H. (2004) Evaluating sandwich immunoassays in microarray format in terms of the ambient analyte regime. Clin. Chem. 50, 1907-1920
    • (2004) Clin. Chem. , vol.50 , pp. 1907-1920
    • Saviranta, P.1    Okon, R.2    Brinker, A.3    Warashina, M.4    Eppinger, J.5    Geierstanger, B.H.6
  • 11
    • 17044401009 scopus 로고    scopus 로고
    • Protein chip-based microarray profiling of oxidized low density lipoprotein-treated cells
    • Sukhanov, S., and Delafontaine, P. (2005) Protein chip-based microarray profiling of oxidized low density lipoprotein-treated cells. Proteomics 5, 1274-1280
    • (2005) Proteomics , vol.5 , pp. 1274-1280
    • Sukhanov, S.1    Delafontaine, P.2
  • 12
    • 0036230933 scopus 로고    scopus 로고
    • Zeptosens' protein microarrays: A novel high performance microarray platform for low abundance protein analysis
    • Pawlak, M., Schick, E., Bopp, M. A., Schneider, M. J., Oroszlan, P., and Ehrat,, M. (2002) Zeptosens' protein microarrays: a novel high performance microarray platform for low abundance protein analysis. Proteomics 2, 383-393
    • (2002) Proteomics , vol.2 , pp. 383-393
    • Pawlak, M.1    Schick, E.2    Bopp, M.A.3    Schneider, M.J.4    Oroszlan, P.5    Ehrat, M.6
  • 13
    • 0031721161 scopus 로고    scopus 로고
    • Ligand assays: From electrophoresis to miniaturized microarrays
    • Ekins, R. P. (1998) Ligand assays: from electrophoresis to miniaturized microarrays. Clin. Chem. 44, 2015-2030
    • (1998) Clin. Chem. , vol.44 , pp. 2015-2030
    • Ekins, R.P.1
  • 14
    • 0026660389 scopus 로고
    • Multianalyte microspot immunoassay. The microanalytical 'compact disk' of the future
    • Ekins, R., and Chu, F. (1992) Multianalyte microspot immunoassay. The microanalyticalcompact disk' of the future. Ann. Biol. Clin. 50, 337-353
    • (1992) Ann. Biol. Clin. , vol.50 , pp. 337-353
    • Ekins, R.1    Chu, F.2
  • 15
  • 16
    • 33644842828 scopus 로고    scopus 로고
    • Antibody microarrays: The crucial impact of mass transport on assay kinetics and sensitivity
    • Kusnezow, W., Syagailo, Y. V., Goychuk, I., Hoheisel, J. D., and Wild, D. G. (2006) Antibody microarrays: the crucial impact of mass transport on assay kinetics and sensitivity. Expert Rev. Mol. Diagn. 6, 111-124
    • (2006) Expert Rev. Mol. Diagn. , vol.6 , pp. 111-124
    • Kusnezow, W.1    Syagailo, Y.V.2    Goychuk, I.3    Hoheisel, J.D.4    Wild, D.G.5
  • 17
    • 21244503901 scopus 로고    scopus 로고
    • Kinetics of protein binding in solid-phase immunoassays: Theory
    • Klenin, K. V., Kusnezow, W., and Langowski, J. (2005) Kinetics of protein binding in solid-phase immunoassays: theory. J. Chem. Phys. 122, 214715
    • (2005) J. Chem. Phys. , vol.122 , pp. 214715
    • Klenin, K.V.1    Kusnezow, W.2    Langowski, J.3
  • 18
    • 0032752117 scopus 로고    scopus 로고
    • The influence of transport on the kinetics of binding to surface receptors: Application to cells and BIAcore
    • Goldstein, B., Coombs, D., He, X., Pineda, A. R., and Wofsy, C. (1999) The influence of transport on the kinetics of binding to surface receptors: application to cells and BIAcore. J. Mol. Recognit. 12, 293-299
    • (1999) J. Mol. Recognit. , vol.12 , pp. 293-299
    • Goldstein, B.1    Coombs, D.2    He, X.3    Pineda, A.R.4    Wofsy, C.5
  • 19
    • 0030571002 scopus 로고    scopus 로고
    • Analysis of mass transport-limited binding kinetics in evanescent wave biosensors
    • Schuck, P., and Minton, A. P. (1996) Analysis of mass transport-limited binding kinetics in evanescent wave biosensors. Anal. Biochem. 240, 262-272
    • (1996) Anal. Biochem. , vol.240 , pp. 262-272
    • Schuck, P.1    Minton, A.P.2
  • 20
    • 0030070499 scopus 로고    scopus 로고
    • Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. 1. A computer simulation of the influence of mass transport
    • Schuck, P. (1996) Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. 1. A computer simulation of the influence of mass transport. Biophys. J. 70, 1230-1249
    • (1996) Biophys. J. , vol.70 , pp. 1230-1249
    • Schuck, P.1
  • 21
    • 0037344024 scopus 로고    scopus 로고
    • Antibody microarrays: An evaluation of production parameters
    • Kusnezow, W., Jacob, A., Walijew, A., Diehl, F., and Hoheisel, J. D. (2003) Antibody microarrays: an evaluation of production parameters. Proteomics 3, 254-264
    • (2003) Proteomics , vol.3 , pp. 254-264
    • Kusnezow, W.1    Jacob, A.2    Walijew, A.3    Diehl, F.4    Hoheisel, J.D.5
  • 22
    • 2342582922 scopus 로고    scopus 로고
    • Enhancing results of microarray hybridizations through microagitation
    • Toegl, A., Kirchner, R., Gauer, C., and Wixforth, A. (2003) Enhancing results of microarray hybridizations through microagitation. J. Biomol. Tech. 14, 197-204
    • (2003) J. Biomol. Tech. , vol.14 , pp. 197-204
    • Toegl, A.1    Kirchner, R.2    Gauer, C.3    Wixforth, A.4
  • 24
    • 0024605425 scopus 로고
    • Immunochemistry at interfaces
    • Nygren, H., and Stenberg, M. (1989) Immunochemistry at interfaces. Immunology 66, 321-327
    • (1989) Immunology , vol.66 , pp. 321-327
    • Nygren, H.1    Stenberg, M.2
  • 25
    • 0021885992 scopus 로고
    • A diffusion limited reaction theory for a solid-phase immunoassay
    • Stenberg, M., and Nygren, H. (1985) A diffusion limited reaction theory for a solid-phase immunoassay. J. Theor. Biol. 113, 589-597
    • (1985) J. Theor. Biol. , vol.113 , pp. 589-597
    • Stenberg, M.1    Nygren, H.2
  • 26
    • 0023718403 scopus 로고
    • Kinetics of antigen-antibody reactions at solid-liquid interfaces
    • Stenberg, M., and Nygren, H. (1988) Kinetics of antigen-antibody reactions at solid-liquid interfaces. J. Immunol. Methods 113, 3-15
    • (1988) J. Immunol. Methods , vol.113 , pp. 3-15
    • Stenberg, M.1    Nygren, H.2
  • 28
    • 0026040457 scopus 로고
    • Time dependent rate of diffusion-influenced ligand binding to receptors on cell surfaces
    • Zwanzig, R., and Szabo, A. (1991) Time dependent rate of diffusion-influenced ligand binding to receptors on cell surfaces. Biophys. J. 60, 671-678
    • (1991) Biophys. J. , vol.60 , pp. 671-678
    • Zwanzig, R.1    Szabo, A.2
  • 29
    • 0242352409 scopus 로고    scopus 로고
    • Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging
    • Weidemann, T., Wachsmuth, M., Knoch, T. A., Muller, G., Waldeck, W., and Langowski, J. (2003) Counting nucleosomes in living cells with a combination of fluorescence correlation spectroscopy and confocal imaging. J. Mol. Biol. 334, 229-240
    • (2003) J. Mol. Biol. , vol.334 , pp. 229-240
    • Weidemann, T.1    Wachsmuth, M.2    Knoch, T.A.3    Muller, G.4    Waldeck, W.5    Langowski, J.6
  • 30
    • 18744391949 scopus 로고    scopus 로고
    • Two-hybrid fluorescence cross-correlation spectroscopy detects protein-protein interactions in vivo
    • Baudendistel, N., Muller, G., Waldeck, W., Angel, P., and Langowski, J. (2005) Two-hybrid fluorescence cross-correlation spectroscopy detects protein-protein interactions in vivo. Chemphyschem 6, 984-990
    • (2005) Chemphyschem , vol.6 , pp. 984-990
    • Baudendistel, N.1    Muller, G.2    Waldeck, W.3    Angel, P.4    Langowski, J.5
  • 31
    • 0025087323 scopus 로고
    • Surface diffusion of interacting proteins. Effect of concentration on the lateral mobility of adsorbed bovine serum albumin
    • Tilton, R. D., Gast, A. P., and Robertson, C. R. (1990) Surface diffusion of interacting proteins. Effect of concentration on the lateral mobility of adsorbed bovine serum albumin. Biophys. J. 58, 1321-1326
    • (1990) Biophys. J. , vol.58 , pp. 1321-1326
    • Tilton, R.D.1    Gast, A.P.2    Robertson, C.R.3
  • 32
    • 0034001127 scopus 로고    scopus 로고
    • Monte Carlo simulation of diffusion of adsorbed proteins
    • Zhdanov, V. P., and Kasemo, B. (2000) Monte Carlo simulation of diffusion of adsorbed proteins. Proteins 39, 76-81
    • (2000) Proteins , vol.39 , pp. 76-81
    • Zhdanov, V.P.1    Kasemo, B.2
  • 33
    • 0028881098 scopus 로고
    • The biophysics of DNA hybridization with immobilized oligonucleotide probes
    • Chan, V., Graves, D. J., and McKenzie, S. E. (1995) The biophysics of DNA hybridization with immobilized oligonucleotide probes. Biophys. J. 69, 2243-2255
    • (1995) Biophys. J. , vol.69 , pp. 2243-2255
    • Chan, V.1    Graves, D.J.2    McKenzie, S.E.3
  • 34
    • 0021904674 scopus 로고
    • Orientation constraints in diffusion-limited macromolecular association. The role of surface diffusion as a rate-enhancing mechanism
    • Berg, O. G. (1985) Orientation constraints in diffusion-limited macromolecular association. The role of surface diffusion as a rate-enhancing mechanism. Biophys. J. 47, 1-14
    • (1985) Biophys. J. , vol.47 , pp. 1-14
    • Berg, O.G.1
  • 35
    • 0026690869 scopus 로고
    • Reaction rate enhancement by surface diffusion of adsorbates
    • Wang, D., Gou, S. Y., and Axelrod, D. (1992) Reaction rate enhancement by surface diffusion of adsorbates. Biophys. Chem. 43, 117-137
    • (1992) Biophys. Chem. , vol.43 , pp. 117-137
    • Wang, D.1    Gou, S.Y.2    Axelrod, D.3
  • 36
    • 0028295474 scopus 로고
    • Reduction-of-dimensionality kinetics at reaction-limited cell surface receptors
    • Axelrod, D., and Wang, M. D. (1994) Reduction-of-dimensionality kinetics at reaction-limited cell surface receptors. Biophys. J. 66, 588-600
    • (1994) Biophys. J. , vol.66 , pp. 588-600
    • Axelrod, D.1    Wang, M.D.2
  • 37
    • 0037620483 scopus 로고    scopus 로고
    • Modeling of DNA hybridization kinetics for spatially resolved biochips
    • Erickson, D., Li, D., and Krull, U. J. (2003) Modeling of DNA hybridization kinetics for spatially resolved biochips. Anal. Biochem. 317, 186-200
    • (2003) Anal. Biochem. , vol.317 , pp. 186-200
    • Erickson, D.1    Li, D.2    Krull, U.J.3
  • 38
    • 13944271437 scopus 로고    scopus 로고
    • Physicochemical perspectives on DNA microarray and biosensor technologies
    • Levicky, R., and Horgan, A. (2005) Physicochemical perspectives on DNA microarray and biosensor technologies. Trends Biotechnol. 23, 143-149
    • (2005) Trends Biotechnol. , vol.23 , pp. 143-149
    • Levicky, R.1    Horgan, A.2
  • 39
    • 0003064682 scopus 로고
    • Reduction of dimensionality in biological diffusion process
    • in (Rich, A., Davidson, N., eds) W. H. Freeman and Co., Publishers, San Francisco
    • Adam, G., and Delbrück, M. (1968) Reduction of dimensionality in biological diffusion process, in Structural Chemistry and Molecular Biology (Rich, A., Davidson, N., eds) pp. 198-215, W. H. Freeman and Co., Publishers, San Francisco
    • (1968) Structural Chemistry and Molecular Biology , pp. 198-215
    • Adam, G.1    Delbrück, M.2
  • 40
    • 0035010395 scopus 로고    scopus 로고
    • Kinetics and thermodynamics of protein adsorption: A generalized molecular theoretical approach
    • Fang, F., and Szleifer, I. (2001) Kinetics and thermodynamics of protein adsorption: a generalized molecular theoretical approach. Biophys. J. 80, 2568-2589
    • (2001) Biophys. J. , vol.80 , pp. 2568-2589
    • Fang, F.1    Szleifer, I.2
  • 41
    • 4444220254 scopus 로고    scopus 로고
    • Effects of temperature and pH on the helicity of a peptide adsorbed to colloidal silica
    • Read, M. J., Mayes, A. M., and Burkett, S. L. (2004) Effects of temperature and pH on the helicity of a peptide adsorbed to colloidal silica. Colloids Surf. B Biointerfaces 37, 113-127
    • (2004) Colloids Surf. B Biointerfaces , vol.37 , pp. 113-127
    • Read, M.J.1    Mayes, A.M.2    Burkett, S.L.3
  • 42
    • 0345827761 scopus 로고    scopus 로고
    • Sparsely cross-linked "nanogels" for microchannel DNA sequencing
    • Doherty, E. A., Kan, C. W., and Barron, A. E. (2003) Sparsely cross-linked "nanogels" for microchannel DNA sequencing. Electrophoresis 24, 4170-4180
    • (2003) Electrophoresis , vol.24 , pp. 4170-4180
    • Doherty, E.A.1    Kan, C.W.2    Barron, A.E.3
  • 43
    • 0035880579 scopus 로고    scopus 로고
    • Microcalorimetric studies on the interaction mechanism between proteins and hydrophobic solid surfaces in hydrophobic interaction chromatography: Effects of salts, hydrophobicity of the sorbent, and structure of the protein
    • Lin, F. Y., Chen, W. Y., and Hearn, M. T. (2001) Microcalorimetric studies on the interaction mechanism between proteins and hydrophobic solid surfaces in hydrophobic interaction chromatography: effects of salts, hydrophobicity of the sorbent, and structure of the protein. Anal. Chem. 73, 3875-3883
    • (2001) Anal. Chem. , vol.73 , pp. 3875-3883
    • Lin, F.Y.1    Chen, W.Y.2    Hearn, M.T.3
  • 44
    • 0036010796 scopus 로고    scopus 로고
    • Thermodynamic analysis of the interaction between proteins and solid surfaces: Application to liquid chromatography
    • Lin, F. Y., Chen, W. Y., and Hearn, M. T. (2002) Thermodynamic analysis of the interaction between proteins and solid surfaces: application to liquid chromatography. J. Mol. Recognit. 15, 55-93
    • (2002) J. Mol. Recognit. , vol.15 , pp. 55-93
    • Lin, F.Y.1    Chen, W.Y.2    Hearn, M.T.3
  • 45
    • 17144427675 scopus 로고    scopus 로고
    • Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens
    • Jones, L. S., Peek, L. J., Power, J., Markham, A., Yazzie, B., and Middaugh, C. R. (2005) Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J. Biol. Chem. 280, 13406-13414
    • (2005) J. Biol. Chem. , vol.280 , pp. 13406-13414
    • Jones, L.S.1    Peek, L.J.2    Power, J.3    Markham, A.4    Yazzie, B.5    Middaugh, C.R.6
  • 46
    • 0035135778 scopus 로고    scopus 로고
    • POIY(L-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: Surface-analytical characterization and resistance to serum and fibrinogen adsorption
    • Huang, N.-P., Michel, R., Voros, J., Textor, M., Hofer, R., Rossi, A., Elbert, D. L., Hubbell, J. A., and Spencer, D. (2001) POIY(L-lysine)-g-poly(ethylene glycol) layers on metal oxide surfaces: surface-analytical characterization and resistance to serum and fibrinogen adsorption. Langmuir 17, 489-498
    • (2001) Langmuir , vol.17 , pp. 489-498
    • Huang, N.-P.1    Michel, R.2    Voros, J.3    Textor, M.4    Hofer, R.5    Rossi, A.6    Elbert, D.L.7    Hubbell, J.A.8    Spencer, D.9
  • 47
    • 0030026989 scopus 로고    scopus 로고
    • Protein adsorption on solid surfaces
    • Hlady, V. V., and Buijs, J. (1996) Protein adsorption on solid surfaces. Curr. Opin. Biotechnol. 7, 72-77
    • (1996) Curr. Opin. Biotechnol. , vol.7 , pp. 72-77
    • Hlady, V.V.1    Buijs, J.2
  • 48
    • 0034295948 scopus 로고    scopus 로고
    • Characterization of protein adsorption and immunosorption kinetics in photoablated polymer microchannels
    • Rossier, J. S., Gokulrangan, G., Girault, H. H., Svojanovsky, S., and Wilson, G. S. (2000) Characterization of protein adsorption and immunosorption kinetics in photoablated polymer microchannels. Langmuir 16, 8489-8494
    • (2000) Langmuir , vol.16 , pp. 8489-8494
    • Rossier, J.S.1    Gokulrangan, G.2    Girault, H.H.3    Svojanovsky, S.4    Wilson, G.S.5
  • 49
    • 0032030193 scopus 로고    scopus 로고
    • Protein adsorption studies on model organic surfaces: An ellipsometric and infrared spectroscopic approach
    • Tengvall, P., Lundstrom, I., and Liedberg, B. (1998) Protein adsorption studies on model organic surfaces: an ellipsometric and infrared spectroscopic approach. Biomaterials 19, 407-422
    • (1998) Biomaterials , vol.19 , pp. 407-422
    • Tengvall, P.1    Lundstrom, I.2    Liedberg, B.3
  • 50
    • 0031848098 scopus 로고    scopus 로고
    • Extending the range of rate constants available from BIACORE: Interpreting mass transport-influenced binding data
    • Myszka, D. G., He, X., Dembo, M., Morton, T. A., and Goldstein, B. (1998) Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data. Biophys. J. 75, 583-594
    • (1998) Biophys. J. , vol.75 , pp. 583-594
    • Myszka, D.G.1    He, X.2    Dembo, M.3    Morton, T.A.4    Goldstein, B.5
  • 51
    • 0035891309 scopus 로고    scopus 로고
    • Kinetics of antigen binding to arrays of antibodies in different sized spots
    • Sapsford, K. E., Liron, Z., Shubin, Y. S., and Ligler, F. S. (2001) Kinetics of antigen binding to arrays of antibodies in different sized spots. Anal. Chem. 73, 5518-5524
    • (2001) Anal. Chem. , vol.73 , pp. 5518-5524
    • Sapsford, K.E.1    Liron, Z.2    Shubin, Y.S.3    Ligler, F.S.4
  • 52
    • 0037250740 scopus 로고    scopus 로고
    • Antibody microarray profiling of human prostate cancer sera: Antibody screening and identification of potential biomarkers
    • Miller, J. C., Zhou, H., Kwekel, J., Cavallo, R., Burke, J., Butler, E. B., Teh, B. S., and Haab, B. B. (2003) Antibody microarray profiling of human prostate cancer sera: antibody screening and identification of potential biomarkers. Proteomics 3, 56-63
    • (2003) Proteomics , vol.3 , pp. 56-63
    • Miller, J.C.1    Zhou, H.2    Kwekel, J.3    Cavallo, R.4    Burke, J.5    Butler, E.B.6    Teh, B.S.7    Haab, B.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.