Hepatobiliary function assessed by 99mTc-mebrofenin cholescintigraphy in the evaluation of severity of steatosis in a rat model

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 33, Issue 10, 2006, Pages 1107-1114

  Veteläinen, Reeta L ^a   Bennink, Roelof J ^a   De Bruin, Kora ^a   Van Vliet, Arlène ^a   Van Gulik, Thomas M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

99mTc mebrofenin; Hepatobiliary scintigraphy; Inflammation; Liver function; Steatosis

Indexed keywords

MEBROFENIN TC 99M; METHIONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORRELATION ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; FATTY LIVER; FIBROGENESIS; HEPATITIS; HEPATOBILIARY SCINTISCANNING; LIPID STORAGE; LIVER CELL DAMAGE; LIVER HISTOLOGY; MALE; NONHUMAN; PROTHROMBIN TIME; RAT;

ANIMALS; BILIARY TRACT; DISEASE MODELS, ANIMAL; FATTY LIVER; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMINO ACIDS; LIVER; LIVER FUNCTION TESTS; MALE; ORGANOTECHNETIUM COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; SEVERITY OF ILLNESS INDEX;

EID: 33749246912     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-006-0125-3     Document Type: Article

References (31)

1. Underwood G. Prevalence of fatty liver in healthy male adults accidentally killed. Aviat Space Environ Med 1984;55:59-63
2. Hilden M, Christoffersen P, Juhl E, Dahlgaard JB. Liver histology in a 'normal' population - examinations of 503 consecutive fatal traffic casualties. Scand J Gastroenterol 1977;12:593-597
3. Diehl AM. Nonalcoholic steatohepatitis. Semin Liver Dis 1999;19:221-229
4. McGill DB, Rakela J, Zinsmeister AR, Ott BJ. A 21-year experience with major hemorrhage after percutaneous liver biopsy. Gastroenterology 1990;99:1396-1400
5. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002;123:745-750
6. Pizarro M, Balasubramaniyan N, Solis N, Solar A, Duarte I, Miguel JF, et al. Bile secretory function in obese Zucker rat: evidence of cholestasis and altered bile canalicular transport function. Gut 2004;53:1837-1843
7. Elferink RO, Groen AK. Genetic defects in hepatobiliary transport. Biochem Biophys Acta 2002;1586:129-145
8. Arrese M, Ananthanarayanan M, Suchy FJ. Hepatobiliary transport: molecular mechanisms of development and cholestasis. Pediatr Res 1998;44:141-147
9. Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 1998;339:1217-1227
10. Krishnamurthy GT, Krishnamurthy S. Nuclear hepatology, a textbook of hepatobiliary diseases. Berlin Heidelberg New York: Springer, 2000
11. Daniel GB, DeNovo RC, Schultze AE, Schmidt D, Smit GT. Hepatic extraction efficiency of technetium-99m-mebrofenin in the dog with toxic-induced acute liver disease. J Nucl Med 1998;39:1286-1292
12. 99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease. J Nucl Med 2002;43:246-252
13. 99mTc-trimethyl-Br-IDA discriminates between different degrees of severe liver ischemia-reperfusion injury in the rat. Eur Surg Res 1997;29:346-355
14. Erdogan D, Heijnen BHM, Bennink RJ, Kok M, Dinant S, Straatsburg IH, et al. Preoperative assessment of liver function: a comparison of technetium-99m mebrofenin scintigraphy with indocyanine green clearance test. Liver Int 2004;24:117-123
15. Koteish A, Diehl AM. Animal models of steatosis. Semin Liver Dis 2001;21:89-104
16. Habraken JB, de Bruin K, Shehata M, Booij J, Bennink R, van Eck Smit BL, et al. Evaluation of high-resolution pinhole SPECT using a small rotating animal. J Nucl Med 2001;12:1863-1869
17. Ekman M, Fjalling M, Holmberg S, Person H. IODIDA clearance rate: a method for measuring hepatocyte uptake function. Transplant Proc 1992;24:387-388
18. Bennink RJ, Vetelainen R, DeBruin C, van Vliet AK, van Gulik TM. Imaging of liver function with dedicated animal dynamic pinhole scintigraphy in rats. Nucl Med Commun 2005;26:1008-1012
19. Fritzberg AR. The evaluation of hepatocyte function with radiotracers. In: Billinghurst MW, Colombetti LG, editors. Studies of cellular function using radiotracers. Boca Raton, Fl: CRC Press; 1982. pp 73-92
20. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003;37:1202-1219
21. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497-502
22. Colquhoun SD, Connelly CA, Vera DR. Portal-systemic shunts reduce asialoglycoprotein receptor density in rats. J Nucl Med 2001;42:110-116
23. Nunn AD, Loberg MD, Conley RA. A structure-distribution relationship approach leading to the development of Tc-99m mebrofenin: an improved cholescintigraphic agent. J Nucl Med 1983;24:423-430
24. Svensson G, Fjalling M, Gretarsdottir J, Jacobsson L, Holmberg SB. Kupffer cell and hepatocyte function in rat transplanted liver. Transpl Int 1992;5(Suppl 1):S417-S419
25. Bennink RJ, Dinant S, Erdogan D, Heijnen BH, Straatsburg IH, van Vliet AK, et al. Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med 2004;45:965-971
26. Loberg MD, Cooper M, Harvey E, Callery P, Faith W. Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. J Nucl Med 1976;17:633-638
27. Hendrikse HN, Kuipers F, Meijer C, Havinga R, Bijleveld CMA, Graaf TA, et al. In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein. Cancer Chem Pharm 2004;24131-138
28. Cui Y, König J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 2000;276:9626-9630
29. Geier A, Zollner G, Dietrich CG, Wagner M, Fickert P, Denk H, et al. Effects of proinflammatory cytokines on rat organic anion transporters during the toxic liver injury and cholestasis. Hepatology 2003;38:345-354
30. Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate the expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther 2002;303:273-281
31. Joseph B, Bhargava KK, Tronco G, Kumaran V, Palestro CJ, Gupta S. Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation. J Nucl Med 2005;46:146-152