99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease

Journal of Nuclear Medicine

Volumn 43, Issue 2, 2002, Pages 246-252

  Malhi, Harmeet ^a   Bhargava, Kuldeep K ^a   Afriyie, Menes O ^a   Volenberg, Irene ^a   Schilsky, Michael L ^a   Palestro, Christopher J ^a   Gupta, Sanjeev ^a  

^a LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

99mTc mebrofenin; Liver; Wilson's disease

Indexed keywords

ALANINE AMINOTRANSFERASE; COPPER; MEBROFENIN TC 99M; BILIRUBIN; CERULOPLASMIN; DIAGNOSTIC AGENT; IMINO ACID; RADIOPHARMACEUTICAL AGENT; SERUM ALBUMIN; TECHNETIUM COMPLEX; TECHNETIUM TC 99M MEBROFENIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; CORRELATION FUNCTION; DIAGNOSTIC VALUE; DISEASE COURSE; EVALUATION; HISTOPATHOLOGY; INTOXICATION; LIVER DISEASE; LIVER FUNCTION; LIVER HISTOLOGY; LIVER SCINTISCANNING; NONHUMAN; PRIORITY JOURNAL; RAT; WILSON DISEASE; ANIMAL; BLOOD; LIVER; LIVER FUNCTION TEST; LONG EVANS CINNAMON RAT; LONG EVANS RAT; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SCINTISCANNING;

ALANINE TRANSAMINASE; ANIMALS; BILIRUBIN; CERULOPLASMIN; COPPER; HEPATOLENTICULAR DEGENERATION; IMINO ACIDS; LIVER; LIVER FUNCTION TESTS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEC; RATS, LONG-EVANS; SERUM ALBUMIN;

EID: 0036008188     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Hepatic extraction efficiency and excretion rate of technetium-99m-mebrofenin in dogs
2. Hepatobiliary scintigraphy in infants
3. 99mTc-mebrofenin (iminodiacetate derivative). III. Chronic CC14-induced liver damage with eventual cirrhosis in rabbits
4. Hepatobiliary scintigraphy in the evaluation of feline liver disease
5. 99mTc-trimethyl-Br-IDA discriminates between different degrees of severe liver ischaemia-reperfusion injury in the rat
6. Hepatic extraction efficiency of technetium-99m-mebrofenin in the dog with toxic-induced acute liver disease
7. Auxiliary liver transplantation in patients with fulminant hepatic failure: Hepatobiliary scintigraphic follow-up
8. Hepatocyte transplantation: Emerging insights into mechanisms of liver repopulation and their relevance to potential therapies
9. Replacement of diseased mouse liver by hepatic cell transplantation
10. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type 1
11. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine
12. Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation
13. Transplanted hepatocytes engraft survive and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis
14. Hepatocyte transplantation in a model of toxin-induced liver disease: Variable therapeutic effect during replacement of damaged parenchyma by donor cells
15. Correction of liver disease following transplantation of normal hepatocytes in LEC rats modeling Wilson's disease
16. Familial cholestatic cirrhosis associated with Kayser-Fleiseher rings
17. The Long-Evans Cinnamon rat: An animal model for Wilson's disease
18. Spontaneous cholangiofibrosis in Long-Evans Cinnamon rats: A rodent model for Wilson's disease
19. Biliary copper excretion capacity in intact animals: Correlation between ATP7B function, hepatic mass, and biliary copper excretion
20. Uptake of technetium 99m hepatobiliary imaging agents by cultured rat hepatocytes
21. A marked increase in free copper levels in the plasma and liver of LEC rats: An animal model for Wilson disease and liver cancer
22. Increased polyploidy, delayed mitosis and reduced protein phosphatase-1 activity associated with excess copper in the Long Evans Cinnamon rat
23. Albumin dialysis: Effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: A new possibility for the elimination of protein-bound toxins
24. Evaluation of plasma time-activity curves of technetium-99m-mebrofenin for measurement of hepatic function in dogs