Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation

Journal of Nuclear Medicine

Volumn 46, Issue 1, 2005, Pages 146-152

  Joseph, Brigid ^a   Bhargava, Kuldeep K ^b   Tronco, Gene G ^b   Kumaran, Vinay ^a   Palestro, Christopher J ^b   Gupta, Sanjeev ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

Author keywords

99mT mebrofenin; Cytokines; Inflammation; Liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; BILIRUBIN; CARBON TETRACHLORIDE; CYTOKINE; INTERLEUKIN 6; MEBROFENIN; MEBROFENIN TC 99M; TUMOR NECROSIS FACTOR ALPHA; DIAGNOSTIC AGENT; IMINO ACID; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M MEBROFENIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE CLASSIFICATION; DRUG ACTIVITY; DRUG EXCRETION; DRUG HALF LIFE; DRUG TRANSPORT; DRUG WITHDRAWAL; HEPATITIS; HEPATOBILIARY SYSTEM; HISTOPATHOLOGY; IMAGE ANALYSIS; IN VITRO STUDY; INCUBATION TIME; LABORATORY TEST; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; REGULATORY MECHANISM; ACTIVE TRANSPORT; ANIMAL; BILE DUCT; COMPARATIVE STUDY; FISCHER 344 RAT; IMMUNOLOGY; LIVER; METABOLIC CLEARANCE RATE; METABOLISM; SCINTISCANNING; TISSUE DISTRIBUTION; TOXIC HEPATITIS;

ANIMALS; BILE DUCTS; BIOLOGICAL TRANSPORT, ACTIVE; CARBON TETRACHLORIDE; CYTOKINES; HEPATITIS, TOXIC; IMINO ACIDS; LIVER; METABOLIC CLEARANCE RATE; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

EID: 15044350014     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Callewaert N, Van Vlierberghe H, Van Hecke A, Laroy W, Delanghe J, Contreras R. Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics. Nat Med. 2004;10:429-434.
2. Joseph B, Bhargava KK, Malhi H., et al. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes. Eur J Nucl Med. 2003;30:1024-1031.
3. Daniel GB, Bahr A, Dykes JA, DeNovo R, Young K, Smith GT. Hepatic extraction efficiency and excretion rate of technetiun-99m-mebrofenin in dogs. J Nucl Med. 1996;37:1846-1849.
4. Howman-Giles R, Uren R, Bernard E, Dorney S. Hepatobiliary scintigraphy in infants. J Nucl Med. 1998;39:311-319.
5. 4-induced liver damage with eventual cirrhosis in rabbits. Int J Occup Med Environ Health. 1995;8:255-265.
6. Newell SM, Selcer BA, Roberts RE, Cornelius LM, Mahaffey EA. Hepatobiliary scintigraphy in the evaluation of feline liver disease. J Veter Intern Med. 1996;10:308-315.
7. 99mTc-trimethyl-Br-IDA discriminates between different degrees of severe liver ischaemia-reperfusion injury in the rat. Ear Surg Res. 1997;29:346-355.
8. Daniel GB, DeNovo RC, Schultze AE, Schmidt D, Smith GT. Hepatic extraction efficiency of technetium-99m-mebrofenin in the dog with toxic-induced acute liver disease. J Nucl Med. 1998;39:1286-1292.
9. 99mTc-Mebrofenin scintiscanning for evaluating liver disease in a rat model of Wilson's disease. J Nucl Med. 2002;43:246-252.
10. Keeffe EB, Lieberman DA, Krishnamurthy S, Krishnamurthy GT, Gilbert S. Scintigraphic features of primary biliary cirrhosis: comparison with sclerosing cholangitis. Radiology. 1988;166:143-148.
11. Koruk M, Ozkilic S, Savas MC, Celen Z, Kadayifci A, Ozkilic C. Evaluation of hepatic functions and biliary dynamics in patients with liver cirrhosis by quantitative scintigraphy. Hepatogastroenterology. 2003;50:1803-1805.
12. Jansen PLM, Sturm E. Genetic cholestasis, causes and consequences for hepatobiliary transport. Liver Int. 2003;23:315-322.
13. Gagandeep S, Rajvanshi P, Sokhi R., et al. Transplanted hepatocytes engraft, survive and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis. J Pathol. 2000;191:78-85.
14. Cai J, Ito M, Nagata H, et al. Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes. Hepatology. 2002;36:386-394.
15. Batts KP, Ludwig J. Chronic hepatitis, and update on terminology and reporting. Am J Surg Pathol. 1995;19:1409-1417.
16. Jones BE, Chau RL, Liu H., et al. Hepatocytes sensitized to tumor necrosis factor-ot cytotoxicity undergo apoptosis through caspase-dependent and caspase-independent pathways. J Biol Chem. 2000;275:705-712.
17. Giri RK, Malhi H, Joseph B, Kandimalla J, Gupta S. Metal catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways. Exp Cell Res. 2003;291:451-462.
18. Gilbert S, Brown PH, Krishnamurthy GT. Quantitative nuclear hepatology. J Nucl Med Technol. 1987;15:38-43.
19. Geier A, Dietrich CG, Voigt S, et al. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology. 2003;38:345-354.
20. Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002;303:273-281.
21. Lan JA, Chervu LR, Johansen KL, Wolkoff AW. Uptake of technetium 99m hepatobiliary imaging agents by cultured rat hepatocytes. Gastroenterology. 1988;95:1625-1631.