Coaggregation of FcεRI with FcγRIIB inhibits degranulation but not induction of Bcl-2 family members A1 and Bim in mast cells

Allergy, Asthma and Clinical Immunology

Volumn 2, Issue 3, 2006, Pages 87-97

  Ekoff, Maria ^a   Möller, Christine ^a   Xiang, Zou ^b   Nilsson, Gunnar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CD32 ANTIGEN; FC EPSILON RECEPTOR I; FC GAMMA RECEPTOR II B; FC RECEPTOR; IMMUNOGLOBULIN E RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

A1 GENE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGRANULATION; MAST CELL; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 33749188754     PISSN: 17101484     EISSN: None     Source Type: Journal    
DOI: 10.2310/7480.2006.00011     Document Type: Article

References (44)

1. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997;77:1033-79.
2. Daëron M. Fc receptor biology. Annu Rev Immunol 1997;15:203-34.
3. Ott VL, Cambier JC. Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention? J Allergy Clin Immunol 2000;106:429-40.
4. Blank U, Ra C, Miller L, et al. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 1989;337:187-9.
5. Turner H, Kinet JP. Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature 1999;402(6760 Suppl):B24-30.
6. Hulett MD, Hogarth PM. Molecular basis of Fc receptor function. Adv Immunol. 1994;57:1-127.
7. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell 1994;76:263-74.
8. Bolland S, Ravetch JV. Inhibitory pathways triggered by ITIM-containing receptors. Adv Immunol 1999;72:149-77.
9. Daëron M, Latour S, Malbec O, et al. The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995;3:635-46.
10. Ravetch JV, Bolland S. IgG Fc receptors. Annu Rev Immunol 2001;19:275-90.
11. Ono M, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature 1996;383:263-6.
12. Daëron M, Malbec O, Latour S, et al. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 1995;95:577-85.
13. Malbec O, Fong DC, Turner M, et al. Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol 1998;160:1647-58.
14. Huber M, Helgason CD, Damen JE, et al. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A 1998;95:11330-5.
15. Lesourne R, Fridman WH, Daëron M. Dynamic interactions of Fc gamma receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fc epsilon receptor I signaling. J Immunol 2005;174:1365-73.
16. Ott VL, Tamir I, Niki M, et al. Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling. J Immunol 2002;168:4430-9.
17. Alfredsson J, Moller C, Nilsson G. IgE-receptor activation of mast cells regulates phosphorylation and expression of forkhead and Bcl-2 family members. Scand J Immunol 2006;63:1-6.
18. Alfredsson J, Puthalakath H, Martin H, et al. Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation. Cell Death Differ 2005;12:136-44.
19. Möller C, Alfredsson J, Engström M, et al. Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 2005;106:1330-6.
20. Xiang Z, Ahmed AA, Möller C, et al. Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation. J Exp Med 2001;194:1561-9.
21. Young JD, Liu CC, Butler G, et al. Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor. Proc Natl Acad Sci U S A 1987;84:9175-9.
22. Takizawa F, Adamczewski M, Kinet JP. Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII. J Exp Med 1992;176:469-75.
23. Dastych J, Hardison MC, Metcalfe DD. Aggregation of low affinity IgG receptors induces mast cell adherence to fibronectin: requirement for the common FcR gamma-chain. J Immunol 1997;158:1803-9.
24. Hemmings BA. Akt signaling: linking membrane events to life and death decisions. Science 1997;275:628-30.
25. Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 1998;335(Pt 1):1-13.
26. Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 1999;96:857-68.
27. Dijkers PF, Medema RH, Lammers JW, et al. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000;10:1201-4.
28. Shinjyo T, Kuribara R, Inukai T, et al. Down-regulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol 2001;21:854-64.
29. Klippel A, Kavanaugh WM, Pot D, Williams LT. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. Mol Cell Biol 1997;17:338-44.
30. Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997;387:673-6.
31. Alessi DR, Andjelkovic M, Caudwell B, et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996;15:6541-51.
32. Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol 1997;7:261-9.
33. Aman MJ, Lamkin TD, Okada H, et al. The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J Biol Chem 1998;273:33922-8.
34. Malbec O, Schmitt C, Brunns P, et al. Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB. J Biol Chem 2001;276:30381-91.
35. Noble KE, Wickremasinghe RG, DeCornet C, et al. Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis. J Immunol 1999;162:1376-83.
36. Lin EY, Orlofsky A, Wang HG, et al. A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 1996;87:983-92.
37. Xiang Z, Möller C, Nilsson G. IgE-receptor activation induces survival and expression of the prosurvival gene bfl-1 in human mast cells but not in basophils. Allergy 2006. [DOI]
38. Flicker S, Valenta R. Renaissance of the blocking antibody concept in type I allergy. Int Arch Allergy Immunol 2003;132:13-24.
39. Zhu D, Kepley CL, Zhang M, et al. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med 2002;8:518-21.
40. Saxon A, Zhu D, Zhang K, et al. Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases. Curr Opin Allergy Clin Immunol 2004;4:563-8.
41. Takai T, Ono M, Hikida M, et al. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature 1996;379:346-9.
42. Yamaguchi M, Lantz CS, Oettgen HC, et al. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med 1997;185:663-72.
43. MacGlashan D Jr, McKenzie-White J, Chichester K, et al. In vitro regulation of Fcepsilon-RIalpha expression on human basophils by IgE antibody. Blood 1998;91:1633-43.
44. Ujike A, Ishikawa Y, Ono M, et al. Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG. J Exp Med 1999;189:1573-9.