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Volumn 6, Issue 4, 2006, Pages 193-196

The calcineurin-NFAT pathway and bone: Intriguing new findings

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CHEMOKINE; FRIZZLED PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 33749025045     PISSN: 15340384     EISSN: None     Source Type: Journal    
DOI: 10.1124/mi.6.4.4     Document Type: Review
Times cited : (24)

References (32)
  • 1
    • 0027409389 scopus 로고
    • The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
    • Boise, L.H., Petryniak, B., Mao, X. et al. The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol. Cell. Biol. 13, 1911-1199 (1993).
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 1911-11199
    • Boise, L.H.1    Petryniak, B.2    Mao, X.3
  • 2
    • 0025127909 scopus 로고
    • Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor
    • Verweij, C.L., Guidos, C., and Crabtree, G.R. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J. Biol. Chem. 265, 15788-15795 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 15788-15795
    • Verweij, C.L.1    Guidos, C.2    Crabtree, G.R.3
  • 3
    • 0027411792 scopus 로고
    • The granulocyte/macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer
    • Cockerill, P.N., Shannon, M.F., Bert, A.G., Ryan, G.R., and Vadas, M.A. The granulocyte/macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl. Acad. Sci. U.S.A. 90, 2466-2470 (1993).
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 2466-2470
    • Cockerill, P.N.1    Shannon, M.F.2    Bert, A.G.3    Ryan, G.R.4    Vadas, M.A.5
  • 4
    • 0027251928 scopus 로고
    • Transcription of the interleukin 4 gene is regulated by multiple promoter elements
    • Todd, M.D., Grusby, M.J., Lederer, J.A., Lacy, E., Lichtman, A.H., and Glimcher, L.H. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J. Exp. Med. 177, 1663-7164 (1993).
    • (1993) J. Exp. Med. , vol.177 , pp. 1663-7164
    • Todd, M.D.1    Grusby, M.J.2    Lederer, J.A.3    Lacy, E.4    Lichtman, A.H.5    Glimcher, L.H.6
  • 5
    • 0029103305 scopus 로고
    • Transcription of the murine interleukin 5 gene is regulated by multiple promoter elements
    • Stranick, K.S., Payvandi, F., Zambas, D.N., Umland, S.P., Egan, R.W., Billah, M.M. Transcription of the murine interleukin 5 gene is regulated by multiple promoter elements. J. Biol. Chem. 270, 20575-20582 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 20575-20582
    • Stranick, K.S.1    Payvandi, F.2    Zambas, D.N.3    Umland, S.P.4    Egan, R.W.5    Billah, M.M.6
  • 6
    • 0028044699 scopus 로고
    • Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: Involvement of the conserved lymphokine element 0
    • Tsuboi, A., Masuda, E.S., Naito, Y., Tokumitsu, H., Arai, K., and Arai, N. Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells: Involvement of the conserved lymphokine element 0. Mol. Biol. Cell 5, 119-128 (1994).
    • (1994) Mol. Biol. Cell , vol.5 , pp. 119-128
    • Tsuboi, A.1    Masuda, E.S.2    Naito, Y.3    Tokumitsu, H.4    Arai, K.5    Arai, N.6
  • 7
    • 0027326457 scopus 로고
    • Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter
    • Goldfeld, A.E., McCaffrey, P.G., Strominger, J.L., and Rao, A. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter. J. Exp. Med. 178, 1365-1379 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 1365-1379
    • Goldfeld, A.E.1    McCaffrey, P.G.2    Strominger, J.L.3    Rao, A.4
  • 8
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signaling: Choreographing the social lives of cells
    • Crabtree, G.R. and Olson, E.N. NFAT signaling: Choreographing the social lives of cells. Cell 109 Suppl, S67-S79 (2002).
    • (2002) Cell , vol.109
    • Crabtree, G.R.1    Olson, E.N.2
  • 9
    • 0037018145 scopus 로고    scopus 로고
    • NFAT: Ubiquitous regulator of cell differentiation and adaptation
    • Horsley, V. and Pavlath, G.K. NFAT: Ubiquitous regulator of cell differentiation and adaptation. J. Cell Biol. 156, 771-774 (2002).
    • (2002) J. Cell Biol. , vol.156 , pp. 771-774
    • Horsley, V.1    Pavlath, G.K.2
  • 10
    • 0032510493 scopus 로고    scopus 로고
    • Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
    • de la Pompa, J.L., Timmerman, L.A., Takimoto, H. et al. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature 392, 182-186 (1998).
    • (1998) Nature , vol.392 , pp. 182-186
    • De La Pompa, J.L.1    Timmerman, L.A.2    Takimoto, H.3
  • 13
    • 0035809312 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2
    • Hernandez, G.L., Volpert, O.V., Iniguez, M.A., Lorenzo, E., Martinez-Martinez, S., Grau, R., Fresno, M., and Redondo, J.M. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase 2. J. Exp. Med. 193, 607-620 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 607-620
    • Hernandez, G.L.1    Volpert, O.V.2    Iniguez, M.A.3    Lorenzo, E.4    Martinez-Martinez, S.5    Grau, R.6    Fresno, M.7    Redondo, J.M.8
  • 14
    • 0037931834 scopus 로고    scopus 로고
    • A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts
    • Neal, J.W. and Clipstone, N.A. A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J. Biol. Chem. 278, 17246-17254 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 17246-17254
    • Neal, J.W.1    Clipstone, N.A.2
  • 15
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone, N.A. and Crabtree, G.R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697 (1992).
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 16
    • 23844515714 scopus 로고    scopus 로고
    • NFAT and Osterix cooperatively regulate bone formation
    • Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima, K., and Takayanagi, H. NFAT and Osterix cooperatively regulate bone formation. Nat. Med. 11, 880-885 (2005). This study provides evidence for a role of NFAT in osteoblast differentiation and a mechanism for the effect. Overexpression of NFATc1 in calvarial osteoblast precursor cells stimulated activation of the gene encoding the type I collagen promoter through the zinc-finger transcription factor Osterix, but not through Runx-2 or BMP-2.
    • (2005) Nat. Med. , vol.11 , pp. 880-885
    • Koga, T.1    Matsui, Y.2    Asagiri, M.3    Kodama, T.4    De Crombrugghe, B.5    Nakashima, K.6    Takayanagi, H.7
  • 17
    • 33646890016 scopus 로고    scopus 로고
    • Calcineurin/NFAT signaling in osteoblasts regulates bone mass
    • Winslow, M.M., Pan, M., Starbuck, M., Gallo, E.M., Deng, L., Karsenty, G., and Crabtree, G.R. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev. Cell 10, 771-782 (2006). This study showed effects of NFATc1 on osteoblast proliferation and differentiation, and on osteoblast activation of osteoclasts. Mice that expressed a constitutively nuclear NFATc1 variant (NFATc1nuc) showed rapid osteogenesis, likely mediated through Wnt signaling and not through Runx-2. Osteoclast formation was also promoted, independently of RANKL, but potentially involving the chemokine CCL8.
    • (2006) Dev. Cell , vol.10 , pp. 771-782
    • Winslow, M.M.1    Pan, M.2    Starbuck, M.3    Gallo, E.M.4    Deng, L.5    Karsenty, G.6    Crabtree, G.R.7
  • 18
    • 0035095290 scopus 로고    scopus 로고
    • Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3-E1 osteoblasts in vitro
    • Fornoni, A., Cornacchia, F., Howard, G.A., Roos, B.A., Striker, G.E., and Striker, L.J. Cyclosporin A affects extracellular matrix synthesis and degradation by mouse MC3T3-E1 osteoblasts in vitro. Nephrol. Dial. Transplant. 16, 500-505 (2001).
    • (2001) Nephrol. Dial. Transplant. , vol.16 , pp. 500-505
    • Fornoni, A.1    Cornacchia, F.2    Howard, G.A.3    Roos, B.A.4    Striker, G.E.5    Striker, L.J.6
  • 19
    • 0026478860 scopus 로고
    • Effects of cyclosporin A on rat osteoblasts (ROS 17/2.8 cells) in vitro
    • McCauley, L.K., Rosol, T.J., and Capen, C.C. Effects of cyclosporin A on rat osteoblasts (ROS 17/2.8 cells) in vitro. Calcif. Tissue Int. 51, 291-297 (1992).
    • (1992) Calcif. Tissue Int. , vol.51 , pp. 291-297
    • McCauley, L.K.1    Rosol, T.J.2    Capen, C.C.3
  • 20
    • 28044473838 scopus 로고    scopus 로고
    • Calcineurin regulates bone formation by the osteoblast
    • 2005
    • Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M 2005 Calcineurin regulates bone formation by the osteoblast. Proc. Natl. Acad. Sci. U.S.A. 102, 17130-17135 (2005). Exogenous expression of calcineurin and the use of a calcineurin mutant in osteoblasts supported a role of the pathway in bone formation through the transcription factor Runx-2. This was direct evidence for an effect of calcineurin on osteoblast differentiation.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 17130-17135
    • Sun, L.1    Blair, H.C.2    Peng, Y.3    Zaidi, N.4    Adebanjo, O.A.5    Wu, X.B.6    Wu, X.Y.7    Iqbal, J.8    Epstein, S.9    Abe, E.10    Moonga, B.S.11    Zaidi, M.12
  • 21
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T., Yagi, H., Nomura, S. et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764 (1997).
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3
  • 22
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J.M., Behringer, R.R., and de Crombrugghe, B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29 (2002).
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 23
    • 12344291865 scopus 로고    scopus 로고
    • Bone morphogenetic proteins
    • Chen, D., Zhao, M., Mundy, G.R. Bone morphogenetic proteins. Growth Factors 22, 233-241 (2004).
    • (2004) Growth Factors , vol.22 , pp. 233-241
    • Chen, D.1    Zhao, M.2    Mundy, G.R.3
  • 25
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong, Y., Slee, R.B., Fukai, N. et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107, 513-523 (2001).
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 26
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda, H., Shima, N., Nakagawa, N. et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. U.S.A. 95, 3597-3602 (1998).
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3
  • 27
    • 0032076696 scopus 로고    scopus 로고
    • Osteoporosis after organ transplantation
    • 1998
    • Rodino, M.A. and Shane, E. 1998 Osteoporosis after organ transplantation. Am. J. Med. 104, 459-469 (1998). This is a review which notes that the cyclosporine class of drugs have decreased transplant rejection and improved survival in the patients. The bone loss in patients receiving renal, heart, lung, bone marrow and liver transplants is reviewed. Although measurements of osteocalcin in the patients suggest that cyclosporine increases osteoblastic activity and bone formation, it is pointed out that renal damage from the drug could decrease the clearance of the osteocalcin.
    • (1998) Am. J. Med. , vol.104 , pp. 459-469
    • Rodino, M.A.1    Shane, E.2
  • 28
    • 0029763501 scopus 로고
    • Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation
    • Thiebaud, D., Krieg, M.A., Gillard-Berguer, D., Jacquet, A.F., Goy, J.J., and Burckhardt, P. Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation. Eur. J. Clin. Invest. 26, 549-555 (1995). This was a retrospective study on twenty-four patients who received cyclosporine A as part of the immunosuppressive regimen, which included tapered doses of glucocorticoid, after cardiac transplantation. Bone mineral density decreased, and there was a large increase in osteocalcin, a parameter of osteoblastic activity, indicating high bone turnover. Parathyroid hormone was also increased, and the authors conclude that the increase in bone turnover could have been due to either cyclosporine or secondary hyperparathyroidism.
    • (1995) Eur. J. Clin. Invest. , vol.26 , pp. 549-555
    • Thiebaud, D.1    Krieg, M.A.2    Gillard-Berguer, D.3    Jacquet, A.F.4    Goy, J.J.5    Burckhardt, P.6
  • 29
    • 0022724506 scopus 로고
    • Cyclosporine A inhibits calcemic hormone-induced bone resorption in vitro
    • Stewart, P.J., Green, O.C., and Stern, P.H. Cyclosporine A inhibits calcemic hormone-induced bone resorption in vitro. J. Bone Miner. Res. 1, 285-291 (1986).
    • (1986) J. Bone Miner. Res. , vol.1 , pp. 285-291
    • Stewart, P.J.1    Green, O.C.2    Stern, P.H.3
  • 31
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi, H., Kim, S., Koga, T. et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev. Cell 3, 889-901 (2002). This cutting-edge study on the role of NFAT in osteoclast differentiation demonstrated that RANKL selectively induced NFATc1 expression, that NFAT is essential for embryonic stem cells to differentiate into osteoclasts in response to RANKL, and that NFATc1 acts downstream of RANKL and may represent a "master switch" for the terminal differentiation of osteoclasts.
    • (2002) Dev. Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1    Kim, S.2    Koga, T.3
  • 32
    • 1842690120 scopus 로고    scopus 로고
    • The calcineurin/NFAT signaling pathway regulates osteoclastogenesis in RAW 264.7 cells
    • Hirotani, H., Touhy, N., Woo, J.T., Stern, P.H., and Clipstone, N.A. The calcineurin/NFAT signaling pathway regulates osteoclastogenesis in RAW 264.7 cells. J. Biol. Chem. 279, 13984-13992 (2004). This study used VIVIT, a specific calcineurin inhibitory peptide, to demonstrate that calcineurin is an essential downstream effector of RANKL-induced osteoclastic differentiation in the monocyte/macrophage cell line RAW 264.7. Expression of a constitutively active calcineurin-independent NFATc1 mutant in the RAW 264.7 cells resulted in their differentiation into a mature functional osteoclast phenotype.
    • (2004) J. Biol. Chem. , vol.279 , pp. 13984-13992
    • Hirotani, H.1    Touhy, N.2    Woo, J.T.3    Stern, P.H.4    Clipstone, N.A.5


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