Toll-like receptor signaling and its relevance to intestinal inflammation

Annals of the New York Academy of Sciences

Volumn 1072, Issue , 2006, Pages 332-338

  Cario, Elke ^a   Podolsky, Daniel K ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Host defense; Inflammatory bowel diseases; Innate immunity; Intestinal epithelium; Resident microflora; Therapy

Indexed keywords

TOLL LIKE RECEPTOR;

CELL INTERACTION; CONFERENCE PAPER; ENTERITIS; HOST RESISTANCE; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; INTESTINE EPITHELIUM; MICROFLORA; MOLECULAR INTERACTION; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

EID: 33749014676     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1326.006     Document Type: Conference Paper

References (45)

1. CARIO, E. et al. 2000. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J. Immunol. 164: 966-972.
2. SMITH, P.D. et al. 2001. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J. Immunol. 167: 2651-2656.
3. OTTE, J.M., I.M. ROSENBERG & D. K. PODOLSKY. 2003. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 124: 1866-1878.
4. MAASER, C. et al. 2004. Human intestinal microvascular endothelial cells express toll-like receptor 5: a binding partner for bacterial flagellin. J. Immunol. 172: 5056-5062.
5. HART, A.L. et al. 2005. Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology 129: 50-65.
6. CARIO, E. et al. 2002. Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium. Am. J. Pathol. 160: 165-173.
7. MELMED, G. et al. 2003. Human intestinal epithelial cells are broadly unresponsive to toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J. Immunol. 170: 1406-1415.
8. OTTE, J. M., E. CARIO & D. K. PODOLSKY. 2004. Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126: 1054-1070.
9. DUBUQUOY, L. et al. 2003. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 124: 1265-1276.
10. GARLANDA, C. et al. 2004. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc. Natl. Acad. Sci. USA 101: 3522-3526.
11. QIN, J. et al. 2005. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. J. Biol. Chem. 280: 25233-25241.
12. BOONE, D.L. et al. 2004. The ubiquitin-modifying enzyme A20 is required for termination of toll-like receptor responses. Nat. Immunol. 5: 1052-1060.
13. NEISH, A.S. et al. 2000. Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 289: 1560-1563.
14. KELLY, D. et al. 2004. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat. Immunol. 5: 104-112.
15. HOOPER, L.V. & J.I. GORDON. 2001. Commensal host-bacterial relationships in the gut. Science 292: 1115-1118.
16. RAKOFF-NAHOUM, S. et al. 2004. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241.
17. CARIO, E., G. GERKEN & D.K. PODOLSKY. 2004. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127: 224-238.
18. BASHIR, M.E. et al. 2004. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 172: 6978-6987.
19. VORA, P. et al. 2004. Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J. Immunol. 173: 5398-5405.
20. PODOLSKY, D.K. 2002. Inflammatory bowel disease. N. Engl. J. Med. 347: 417-429.
21. CARIO, E. & D.K. PODOLSKY. 2000. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 68: 7010-7017.
22. HAUSMANN, M. et al. 2002. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122: 1987-2000.
23. ORTEGA-CAVA, C.F. et al. 2003. Strategic compartmentalization of toll-like receptor 4 in the mouse gut. J. Immunol. 170: 3977-3985.
24. SINGH, J. C. et al. 2005. Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G514-G524.
25. ABREU, M.T. et al. 2002. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J. Biol. Chem. 277: 20431-20437.
26. SUZUKI, M., T. HISAMATSU & D. K. PODOLSKY. 2003. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular toll-like receptor 4-MD-2 complex. Infect. Immun. 71: 3503-3511.
27. FRANCHIMONT, D. et al. 2004. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 53: 987-992.
28. ELSON, C.O., Y. CONG & J. SUNDBERG. 2000. The C3H/HeJBir mouse model: a high susceptibility phenotype for colitis. Int. Rev. Immunol. 19: 63-75.
29. RACHMILEWITZ, D. et al. 2004. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126: 520-528.
30. FUKATA, M. et al. 2005. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G1055-G1065.
31. OHKAWARA, T. et al. 2005. Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in toll-like receptor 4 knockout mice. Clin. Exp. Immunol. 141: 412-421.
32. MAHLER, M. et al. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am. J. Physiol. 274: G544-G551.
33. PULL, S.L. et al. 2005. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. USA 102: 99-104.
34. KOBAYASHI, M. et al. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111: 1297-1308.
35. FORT, M.M. et al. 2005. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J. Immunol. 174: 6416-6423.
36. AGRAWAL, S. et al. 2003. Cutting edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen- activated protein kinase and c-Fos. J. Immunol. 171: 4984-4989.
37. KIM, S.C. et al. 2005. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology 128: 891-906.
38. BERG, D.J. et al. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 98: 1010-1020.
39. O'BRIEN, A.D. et al. 1980. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol. 124: 20-24.
40. BIHL, F. et al. 2003. Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice. J. Immunol. 170: 6141-6150.
41. TARGAN, S.R. et al. 2005. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 128: 2020-2028.
42. LODES, M.J. et al. 2004. Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest. 113: 1296-1306.
43. SITARAMAN, S.V. et al. 2005. Elevated flagellin-specific immunoglobulins in Crohn's disease. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G403-G406.
44. OBERMEIER, F. et al. 2005. In vivo CpG DNA/TLR9 interaction induces regulatory properties in CD4+CD62L+-T-cells which prevent intestinal inflammation in the SCID-transfer model of colitis. Gut 54: 1428-1436.
45. JIJON, H. et al. 2004. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Gastroenterology 126: 1358-1373.