Translational medicine: The discovery of bridging biomarkers using pharmacogenomics

Pharmacogenomics

Volumn 7, Issue 6, 2006, Pages 943-947

  Mendrick, Donna L ^a  

^a Gene Logic Inc   (United States)

Author keywords

Biomarker; Bridging biomarker; Critical path initiative; FETUB; Gene ontology; Kim 1; Pharmacogenomics; Pharmacogenomics guidance document; Relational database; Toxicogenomics

Indexed keywords

BIOLOGICAL MARKER; FETUIN; FETUIN B; GENE PRODUCT; KIDNEY INJURY MOLECULE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ACUTE KIDNEY TUBULE NECROSIS; ARTHRITIS; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; DIAGNOSTIC TEST; DISEASE MODEL; DNA MICROARRAY; DRUG EFFICACY; DRUG INDUSTRY; DRUG SAFETY; GENE CONTROL; GENE EXPRESSION; GENE SEQUENCE; GENETIC DATABASE; HUMAN; KIDNEY ISCHEMIA; LIVER INJURY; NONHUMAN; PHARMACOGENETICS; PHARMACOGENOMICS; TOXICOGENETICS; VALIDATION PROCESS;

ANIMALS; BIOLOGICAL MARKERS; DRUG DESIGN; GENE EXPRESSION PROFILING; GENETIC MARKERS; HUMANS; PHARMACOGENETICS; TOXICOGENETICS;

EID: 33749009004     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.7.6.943     Document Type: Article

References (19)

1. Kola I, Landis J: Can the pharmaceutical industry reduce attrition rates? Nature Rev. Drug Discov. 3, 711-715 (2004).
2. DiMasi JA, Hansen RW, Grabowski HG: The price of innovation: new estimates of drug development costs. J. Health Econ. 22, 151-185 (2003).
3. Korstanje R, DiPetrillo K: Unraveling the genetics of chronic kidney disease using animal models. Am. J. Physiol. Renal Physiol. 287, F347-F352 (2004).
4. Boverhof DR, Zacharewski TR: Toxicogenomics in risk assessment: applications and needs. Toxicol. Sci. 89, 352-360 (2006).
5. Firestein GS: Inhibiting inflammation in rheumatoid arthritis. N. Engl. J. Med. 354, 80-82 (2006).
6. Olson H, Betton G, Robinson D et al.: Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32, 56-67 (2000).
7. Heinloth AN, Irwin RD, Boorman GA et al.: Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol. Sci. 80, 193-202 (2004).
8. Cariello NF, Romach EH, Colton HM et al.: Gene expression profiling of the PPAR-α agonist ciprofibrate in the cynomolgus monkey liver. Toxicol. Sci. 88, 250-264 (2005).
9. Peraza MA, Burdick AD, Marin HE, Gonzalez FJ, Peters JM: The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). Toxicol. Sci. 90, 269-295 (2006).
10. Mattes WB, Daniels KK, Summan M, Xu ZA, Mendrick DL: Tissue and species distribution of the glutathione pathway transcriptome. Xenobiotica (2006) (In press).
11. Ein-Dor L, Zuk O, Domany E: Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer. Proc. Natl Acad. Sci. USA 103, 5923-5928 (2006).
12. Burgoon LD, Boutros PC, Dere E, Zacharewski TR: dbZach: a MIAME-compliant toxicogenomic supportive relational database. Toxicol. Sci. 90, 558-568 (2006).
13. Ichimura T, Bonventre JV, Bailly V et al.: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is upregulated in renal cells after injury. J. Biol. Chem. 273, 4135-4142 (1998).
14. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV: Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 62, 237-244 (2002).
15. Ichimura T, Hung CC, Yang SA, Stevens JL, Bonventre JV: Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am. J. Physiol. Renal Physiol. 286, F552-F563 (2004).
16. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV: Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am. J. Physiol. Renal Physiol. 290, F517-F529 (2006).
17. Olivier E, Soury E, Ruminy P et al.: Fetuin B, a second member of the fetuin family in mammals. Biochem. J. 350 Pt 2, 589-597 (2000).
18. Olivier E, Soury E, Risler JL et al.: A novel set of hepatic mRNAs preferentially expressed during an acute inflammation in rat represents mostly intracellular proteins. Genomics 57, 352-364 (1999).
19. Denecke B, Graber S, Schafer C, Heiss A, Woltje M, Jahnen-Dechent W: Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A. Biochem. J. 376, 135-145 (2003).