Inhibiting inflammation in rheumatoid arthritis

New England Journal of Medicine

Volumn 354, Issue 1, 2006, Pages 80-82

  Firestein, Gary S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ARTICLE; B LYMPHOCYTE; DISEASE MODEL; DOSE RESPONSE; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME SUBSTRATE COMPLEX; HUMAN; IMMUNITY; INFLAMMATION; JOINT DESTRUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARTHRITIS, RHEUMATOID; COLLAGEN; DISEASE MODELS, ANIMAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INFLAMMATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 30044448132     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr054344     Document Type: Article

References (5)

1. Camps M, Ruckle T, Ji H, et al. Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 2005;11:936-43.
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3. Curnock AP, Logan MK, Ward SG. Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases. Immunology 2002;105:125-36.
4. Nandakumar KS, Svensson L, Holmdahl R. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol 2003;163:1827-37.
5. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-61.