Despite having a common P1 Leu, eglin C inhibits α-lytic proteinase a million-fold more strongly than does Turkey ovomucoid third domain

Biochemistry

Volumn 45, Issue 38, 2006, Pages 11342-11348

  Qasim, M A ^a,d   Van Etten, Robert L ^a   Yeh, Tina ^b   Saunders, C ^c   Ganz, P J ^c   Qasim, S ^a   Wang, L ^a   Laskowski Jr , M ^a  

^a PURDUE UNIVERSITY   (United States)

^b ACCELRYS INC   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION REACTIONS; CONFORMATIONS; ENZYME INHIBITION; ENZYME KINETICS; REACTION KINETICS;

COMPUTATIONAL PROTEIN DOCKING; EQUILIBRIUM CONSTANTS; INTRASCAFFOLDING; PROTEINASE;

ENZYMES;

DOCKING PROTEIN; EGLIN C; LEUCINE; OVOMUCOID; PROTEINASE; SERINE PROTEINASE INHIBITOR; TURKEY OVOMUCOID THIRD DOMAIN; UNCLASSIFIED DRUG; APROTININ; EGLIN PROTEINASE INHIBITORS; MYXOBACTER ALPHA LYTIC PROTEINASE; MYXOBACTER ALPHA-LYTIC PROTEINASE; OVOMUCOID INHIBITORS; PROTEIN; SERINE PROTEINASE;

ARTICLE; CHEMICAL REACTION; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; EQUILIBRIUM CONSTANT; MATHEMATICAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN VARIANT; TURKEY (BIRD); WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BIRD; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; XANTHOMONADACEAE;

AMINO ACID SEQUENCE; ANIMALS; BIRDS; KINETICS; LEUCINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SEQUENCE ALIGNMENT; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TRYPSIN INHIBITOR, KAZAL PANCREATIC; XANTHOMONADACEAE;

EID: 33749000905     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060445l     Document Type: Article

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