Immunopathologic effects associated with Sarcocystis neurona-infected interferon-gamma knockout mice

Journal of Parasitology

Volumn 89, Issue 5, 2003, Pages 932-940

  Witonsky, Sharon G ^a   Gogal Jr , Robert M ^a,b   Duncan, Robert B ^a   Lindsay, David S ^a,b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b CENTER FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN;

IMMUNE RESPONSE; PARASITOLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; B LYMPHOCYTE; BLOOD; CELL COUNT; CONFERENCE PAPER; CONTROLLED STUDY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; GERMINAL CENTER; HISTOPATHOLOGY; IMMUNOPATHOLOGY; INFLAMMATORY INFILTRATE; INTERSTITIAL PNEUMONIA; KNOCKOUT MOUSE; LIVER; LUNG; LYMPH NODE; LYMPHADENOPATHY; LYMPHOCYTE ACTIVATION; LYMPHOID HYPERPLASIA; LYMPHOID ORGAN; MEROZOITE; MOUSE; NONHUMAN; PROTOZOAL INFECTION; SARCOCYSTIS NEURONA; SPLEEN CELL; SPLENOMEGALY; STATISTICAL SIGNIFICANCE;

AGGLUTINATION TESTS; ANIMALS; ANTIBODIES, PROTOZOAN; B-LYMPHOCYTES; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; IMMUNITY, CELLULAR; INTERFERON TYPE II; LIVER; LUNG; LYMPH NODES; LYMPHOCYTE COUNT; MICE; MICE, KNOCKOUT; SARCOCYSTIS; SARCOCYSTOSIS; SPLEEN;

ANIMALIA; PROTOZOA; SARCOCYSTIS; SARCOCYSTIS NEURONA;

EID: 0344420388     PISSN: 00223395     EISSN: None     Source Type: Journal    
DOI: 10.1645/GE-72R     Document Type: Conference Paper

References (27)

1. BARRAGAN, A., AND L. SIBLEY. 2002. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. Journal of Experimental Medicine 195: 1625-1633.
2. BELZ, G., J. ALTMAN, AND P. DOHERTY. 1998. Characteristics of virus specific CD8+ T cells in the liver during the control and resolution phases of influenza pneumonia. Proceedings of the National Academy of Sciences 95: 13812-13817.
3. BRUNTON, S., G. WALLACE, E. GRAHAM, AND M. STANFORD. 2000. The effects of cytokines on the replication of T. gondii within rat retinal vascular endothelial cells. Journal of Neuroimmunology 102: 182-188.
4. CUTLER, T., R. MACKAY, P. GINN, K. GILLIS, S. TANHAUSER, F. LERAY, J. DARNE, AND E. GREINER. 2001. Immunocon version against Sarcocystis neurona in normal and dexarnethasone treated horses challenged with Sarcocystis neurona. Veterinary Parasitology 95: 197-210.
5. DAFT, B., B. BARR, I. GARDNER, D. READ, W. BELL, K. PEYSER, A. ARDANS, H. KINDE, AND J. MORROW. 2002. Sensitivity and specificity of western blot testing of cerebrospinal fluid and serum for diagnosis of equine protozoal myeloencephalitis in horses with and without neurologic abnormalities. Journal of the American Veterinary Medical Association 221: 1007-1013.
6. DUBEY, J. F. 2001a. Parasitemia and early tissue localization of Sarcocystis neurona in gamma-interferon knock-out mice fed sporocysts. Journal of Parasitology 8: 1476-1479.
7. -. 2001b. Migration and development of Sarcocystis neurona in tissues in interferon-gamma knockout mice fed sporocysts from a naturally infected opossum. Veterinary Parasitology 95: 341-351.
8. -, AND D. S. LINDSAY. 1998. Isolation in immunodeficient mice of Sarcocystis neurona from opposum (Didelphis virginiana) faeces and its differentiation from Sarcocystis falcatula. International Journal for Parasitology 28: 1823-1828.
9. FENGER, C., D. GRANSTROM, A. GAJADHAR, N. WILLIAMS, S. MCCRILLIS, S. STAMPER, J. LONGEMEIER, AND J. P. DUBEY. 1997. Experimental induction of equine protozoal myeloencephalitis in horses using Sarcocystis sp. sporocysts from the opossum (Didelphis virginiana). Veterinary Parasitology 68: 199-213.
10. FRITZ, D., AND J. P. DUBEY. 2002. Pathology of Sarcocystis neurona in gamma-interferon knock-out mice. Veterinary Pathology 39: 137-140.
11. GAZZINELLI, R., Y. XU, S. HIENY, A. CHEEVER, AND A. SHER. 1992. Simulataneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. Journal of Immunology 149: 175-180.
12. GOGAL, R., M. PRATER, M. JOHNSON, AND S. HOLLADAY. 2000. Bilateral sections of spleen and thymus in rodents exhibit homogeneity in leukocyte marker expression. Toxicology 157: 217-223.
13. HAMIR, A. N., AND J. P. DUBEY. 2001. Myocarditis and encephalitis associated with Sarcocystis neurona infection in raccoons (Procyon lotor). Veterinary Parasitology 95: 335-340.
14. HUANG, S., AND A. JONG. 2001. Cellular mechanisms of microbial proteins contributing to invasion of the blood brain barrier. Cellular Microbiology 3: 277-287.
15. LINDSAY, D. S., AND J. P. DUBEY. 1999. Determination of the activity of pyrimethamine, trimethoprim, sulfonamides, and combinations of pyrimethamine and sulfonamides against Sarcocystis neurona in cell cultures. Veterinary Parasitology 82: 205-210.
16. -, AND -. 2001. Direct agglutination test for the detection of antibodies to Sarcocystis neurona in experimentally infected animals. Veterinary Parasitology 95: 179-186.
17. MACKAY, R. 1997. Equine protozoal myeloencephalitis. Veterinary Clinics of North America: Equine Practice 13: 79-96.
18. MARSH, A., B. BARR, J. LAKRITZ, R. NORHAUSEN, J. MADIGNA, AND P. CONRAD. 1997. Experimental infection of nude mice as a model for Sarcocystis neurona-associated encephalitis. Parasitology Research 83: 706-711.
19. MARSHALL, D., S. TURNER, G. BELZ, S. WINGO, S. ANDREANSKY, M. SANGSTER, J. RIBERDY, T. LIU, AND P. DOHERTY. 2001. Measuring diaspora for virus specific CD8+ T cells. Proceedings of the National Academy of Sciences 98: 6313-6318.
20. MORISAKI, J., J. HEUSER, AND L. SIBLEY. 1995. Invasion of Toxoplasma gondii occurs by active penetration of the host cell. Journal of Cell Science 108: 2457-2464.
21. PRUNESCU, P. 1999. Hepatic hematopoiesis in adult mouse during experimental rodent malaria. Roum Archives of Microbiological Immunology 58: 79-94.
22. ROONEY, J., M. PRICKETT, AND F. DELANEY. 1970. Focal myelitis-encephalitis in horses. Cornell Veterinarian 60: 494-499.
23. ROSYPAL, A. C., D. S. LINDSAY, R. B. DUNCAN, S. A. AHMED, A. M. ZAJAC, AND J. P. DUBEY. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Veterinary Parasitology 103: 315-321.
24. SAVILLE, W., S. REED, D. GRANSTROM, K. HICHCLIFF, C. KOHN, T. WITTUM, AND S. STAMPER. 1997. Prevalence of serum antibodies to S. neurona in horses in Ohio. Journal of the American Veterinary Medical Association 210: 519-524.
25. -, R. STICH, S. REED, C. NJOKU, M. OGLESBEER, A. NUNSCHMANN, D. GROVER, A. LAREW-NAUGLE, J. STANEK, D. GRANSTROM, AND J. DUBEY. 2001. Utilization of stress in the development of an equine model for equine protozoal myeloencephalitis. Veterinary Parasitology 95: 211-222.
26. TRIPP, R., A. HAMILTON-EASTON, P. CARDIN, P. NGUYEN, F. BEHM, S. WOODLAND, P. DOHERTY, AND M. BLACKMAN. 1997. Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpes virus: Role for a viral superantigen? Journal of Experimental Medicine 185: 1641-1650.
27. WITONSKY, S., R. M. GOGAL, R. B. DUNCAN, AND D. S. LINDSAY. 2003a. Protective immune response to experimental infection with Sarcocystis neurona in C57BL/6 mice. Journal of Parasitology 89: 924-931.