Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of SCH 211803 in rat and monkey plasma using automated 96-well protein precipitation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 799, Issue 2, 2004, Pages 271-280

  Yang, Liyu ^a   Wu, Ning ^a   Clement, Robert P ^a   Rudewicz, Patrick J ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Protein precipitation; SCH 211803

Indexed keywords

MASS SPECTROMETRY; PRECIPITATION (CHEMICAL); PROTEINS;

PLASMA MATRIX;

LIQUID CHROMATOGRAPHY;

1' (2 AMINO 3 METHYLBENZOYL) 4 [[[(3 CHLOROPHENYL)SULFONYL]PHENYL]METHYL] 1,4' BIPIPERIDINE; ACETONITRILE; PIPERIDINE DERIVATIVE; SCH 211803; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MONKEY; NONHUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY;

EID: 0344665701     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2003.10.058     Document Type: Article

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