Inhibitory effects of cariporide on LPC-induced expression of ICAM-1 and adhesion of monocytes to smooth muscle cells in vitro

Acta Pharmacologica Sinica

Volumn 27, Issue 10, 2006, Pages 1326-1332

  Li, Zhi ^a   Song, Tao ^a   Liu, Gui Zhen ^a   Liu, Li Ying ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cariporide; Intercellular adhesion molecule 1; Lysophosphatidylcholine; Monocyte; Na+ H+ exchanger; Smooth muscle cells

Indexed keywords

2',7' BIS(2 CARBOXYETHYL) 5,6 CARBOXYFLUORESCEIN; CARBOXYFLUORESCEIN; CARIPORIDE; INTERCELLULAR ADHESION MOLECULE 1; LYSOPHOSPHATIDYLCHOLINE; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELL MEMBRANE; CELL PH; CELL STIMULATION; DOSE RESPONSE; HUMAN; HUMAN CELL; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; SMOOTH MUSCLE FIBER;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; AORTA; CATTLE; CELL ADHESION; CELLS, CULTURED; GUANIDINES; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYSOPHOSPHATIDYLCHOLINES; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 33748968169     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00412.x     Document Type: Article

References (25)

1. + exchange isoform 1 mRNA expression in isolated rat hearts. Am J Physiol 1999; 277: H993-8.
2. Linz WJ, Busch AE. NHE-1 inhibition: from protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodeling. Naunyn Schmiedebergs Arch Pharmacol 2003; 368: 239-46.
3. Karmazyn M, Sawyer M, Fliegel L. The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention. Curr Drug Targets Cardiovasc Haematol Disord 2005; 5: 323-35.
4. Karmazyn M. Pharmacology and clinical assessment of cariporide for the treatment of coronary artery diseases. Expert Opin Investig Drugs 2000; 9: 1099-108.
5. Tu JH, Liu LY. Selective sodium/hydrogen exchanger inhibitor HOE642 inhibited proliferation of vascular smooth muscle cells. Chin J Pharmacol Toxicol 2001; 15: 260-4.
6. Wang SX, Xiong XM, Song T, Liu LY. Protective effects of cariporide on endothelial dysfunction induced by high glucose. Acta Pharmacol Sin 2005; 26: 329-33.
7. Tu JH, Liu LY, Zhang XH. Protective effect of Na(+)-H+ exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia. J Hu-nan Med Univ 2002; 27: 13-6 (in Chinese).
8. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993; 362: 801-9.
9. Gouni-Berthold I, Sachinidis A. Possible non-classic intracellular and molecular mechanisms of LDL cholesterol action contributing to the development and progression of atherosclerosis. Curr Vasc Pharmacol 2004; 2: 363-70.
10. Scalia R, Murohara T, Campbell B, Kaji A, Lefer AM. Lysophosphatidylcholine stimulates leukocyte rolling and adherence in rat mesenteric microvasculature. Am J Physiol 1997; 272: H2584-90.
11. Watanabe T, Pakala R, Katagiri T, Benedict CR. Lysophosphatidylcholine is a major contributor to the synergistic effect of mildly oxidized low-density lipoprotein with endothelin-1 on vascular smooth muscle cell proliferation. J Cardiovasc Pharmacol 2002; 39: 449-59.
12. Fogelman AM, Elahi F, Sykes K, Van Lenten BJ, Territo MC, Berliner JA. A modification of the Recalde method for the isolation of human monocytes. J Lipid Res 1988; 29: 1243-7.
13. Territo MC, Berliner JA, Almada L, Ramirez R, Fogelman AM. β-very low density lipoprotein pretreatment of endothelial monolayers increases monocyte adhesion. Atherosclerosis 1989; 9: 824-8.
14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
15. Pigott R, Needham LA, Edwards RM, Walker C, Power C. Structural and functional studies of the endothelial activation antigen endothelial leukocyte adhesion molecule-1 using a panel of monoclonal antibodies. J Immunol 1991; 147: 130-5.
16. 2+ in lymphocytes. J Cell Biol 1982; 95: 189-96.
17. Thomas JA, Buchsbaum RN, Zimniak A, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 1979; 18: 2210-8.
18. Chin B, Lip GY. Cariporide aventis. Curr Opin Investig Drugs 2000; 1: 340-6.
19. Kinard F, Jaworski K, Sergent-Engelen T, Goldstein D, Van Veldhoven PP, Holvoet P, et al. Smooth muscle cells influence monocyte response to LDL as well as their adhesion and transmigration in a coculture model of the arterial wall. J Vasc Res 2001; 38: 479-91.
20. Morelli PI, Martinsson S, Ostergren-Lunden G, Friden V, Moses J, Bondjers G, et al. IFNgamma regulates PDGF-receptor alpha expression in macrophages, THP-1 cells, and arterial smooth muscle cells. Atherosclerosis 2006; 184: 39-47.
21. + exchange isoform 1 mRNA expression in isolated rat hearts. Am J Physiol 1999; 277: H993-8.
22. Jung O, Albus U, Lang HJ, Busch AE, Linz W. Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia. Basic Clin Pharmacol Toxicol 2004; 95: 24-30.
23. Koliakos G, Zolota Z, Paletas K, Kaloyianni M. High glucose concentrations stimulate human monocyte sodium/hydrogen exchanger activity and modulate atherosclerosis-related functions. Pflugers Arch 2004; 449: 298-306.
24. Kaloyianni M, Zolota Z, Paletas K, Tsapas A, Koliakos G. Cariporide counteracts atherosclerosis-related functions in monocytes from obese and normal individuals. Obes Res 2005; 13: 1588-95.
25. Lee KU, Lee IK, Han J, Song DK, Kim YM, Song HS, et al. Effects of recombinant adenovirus-mediated uncoupling protein 2 over expression on endothelial function and apoptosis. Circ Res 2005; 96: 1200-7.