Differential response of arcuate proopiomelanocortin- and neuropeptide Y-containing neurons to the lesion produced by gold thioglucose administration

Journal of Comparative Neurology

Volumn 499, Issue 1, 2006, Pages 120-131

  Homma, Akiko ^a   Li, Hong Peng ^a   Hayashi, Kaori ^a,b   Kawano, Yukari ^b   Kawano, Hitoshi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Arcuate nucleus; Axonal regeneration; Feeding related peptide; Hypothalamic lesion; Immunohistochemistry

Indexed keywords

AUROTHIOGLUCOSE; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOREACTIVITY; LATERAL HYPOTHALAMUS; MALE; MOUSE; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE FIBER REGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIRHEUMATIC AGENTS; ARCUATE NUCLEUS; AUROTHIOGLUCOSE; CELL COUNT; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED ICR; NERVE FIBERS; NEURONS; NEUROPEPTIDE Y; PRO-OPIOMELANOCORTIN; TIME FACTORS;

EID: 33748848288     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.21097     Document Type: Article

References (52)

1. Alonso G, Privat A. 1993. Neuropeptide Y-producing neurons of the arcuate nucleus regenerate axons after surgical deafferentation of the mediobasal hypothalamus. J Neurosci Res 34:510-522.
2. Arees EA, Mayer J. 1967. Anatomical connections between medial and lateral regions of the hypothalamus concerned with food intake. Science 157:1574-1575.
3. Arees EA, Veltman BI, Mayer J. 1969. Hypothalamic blood flow following goldthioglucose-induced lesions. Exp Neurol 25:410-415.
4. Bai FL, Yamano M, Shiotani Y, Emson PC, Smith AD, Powell JF, Tohyama M. 1985. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 331:172-175.
5. Bergen HT, Mobbs CV. 1996. Ventromedial hypothalamic lesions produced by gold thioglucose do not impair induction of NPY mRNA in the arcuate nucleus by fasting. Brain Res 707:266-271.
6. Bergen HT, Mizuno TM, Taylor J, Mobbs CV. 1998. Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology 139:4483-4488.
7. Caffyn ZE. 1972. Early vascular changes in the brain of the mouse after injections of goldthioglucose and bipiperidyl mustard. J Pathol 106:49-56.
8. Cone RD. 2005. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578.
9. Debons AF, Krimsky I, Maayan ML, Fani K, Jemenez FA. 1977. Gold thioglucose obesity syndrome. Fed Proc 36:143-147.
10. Debons AF, Krimsky I, From A, Siclari E, Maayan ML, Fani K, Jimenez FA. 1979. Action of gold thioglucose on pericapillary structures in the ventromedial hypothalamus. J Pathol 129:73-81.
11. Diano S, Naftolin F, Goglia F, Horvath TL. 1998. Segregation of the intra-and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Regul Pept 75-76:117-126.
12. Dube MG, Kalra PS, Crowley WR, Kalra SP. 1995. Evidence of a physiological role for neuropeptide Y in ventromedial hypothalamic lesion-induced hyperphagia. Brain Res 690:275-278.
13. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. 1999. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786.
14. Elmquist JK, Elias CF, Saper CB. 1999. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221-232.
15. Erickson JC, Hollopeter G, Palmiter RD. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704-1707.
16. Goldgefter L, Schejter AS, Gill D. 1980. Structural and microspectrofluorometric studies on glial cells from the periventricular and arcuate nuclei of the rat hypothalamus. Cell Tissue Res 211:503-510.
17. Grillon S, Herve C, Griffond B, Fellmann D. 1997. Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat lateral hypothalamus after goldthioglucose injection. Neuropeptides 31:131-136.
18. Hisano S, Kawano H, Nishiyama T, Daikoku S. 1982. Immunoreactive ACTH/beta-endorphin neurons in the tuberoinfundibular hypothalamus of rats. Cell Tissue Res 224:303-314.
19. Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. 1996. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 224:855-862.
20. Joseph SA. 1980. Immunoreactive adrenocorticotropin in rat brain: a neuroanatomical study using antiserum generated against synthetic ACTH. Am J Anat 158:533-548.
21. Kalra SP, Kalra PS. 2004. NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38:201-211.
22. Kawano H, Li HP, Sango K, Kawamura K, Raisman G. 2005. Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axons. J Neurosci Res 80:191-202.
23. Kerkerian L, Pelletier G. 1986. Effects of monosodium L-glutamate administration on neuropeptide Y-containing neurons in the rat hypothalamus. Brain Res 369:388-390.
24. Kiss JZ, Cassell MD, Palkovits M. 1984. Analysis of the ACTH/beta-End/alpha-MSH-immunoreactive afferent input to the hypothalamic paraventricular nucleus of rat. Brain Res 324:91-99.
25. Legradi G, Lechan RM. 1998. The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 139:3262-3270.
26. Leibowitz SF, Wortley KE. 2004. Hypothalamic control of energy balance: different peptides, different functions. Peptides 25:473-504.
27. Leloup C, Arluison M, Lepetit N, Cartier N, Marfaing-Jallat P, Ferre P, Penicaud L. 1994. Glucose transporter 2 (GLUT 2): expression in specific brain nuclei. Brain Res 638:221-226.
28. Liebelt RA, Sekiba K, Liebelt AG, Perry JH. 1960. Genetic susceptibility to goldthioglucose-induced obesity in mice. Proc Soc Exp Biol Med 104:689-692.
29. Likuski HJ, Debons AF, Cloutier RJ. 1967. Inhibition of gold thioglucose-induced hypothalamic obesity by glucose analogues. Am J Physiol 212:669-676.
30. Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK. 2003. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23:7143-7154.
31. Marks JL, Waite K, Cameron-Smith D, Blair SC, Cooney GJ. 1996. Effects of gold thioglucose on neuropeptide Y messenger RNA levels in the mouse hypothalamus. Am J Physiol 270:R1208-R1214.
32. Marshall NB, Barrnett RJ, Mayer J. 1955. Hypothalamic lesions in gold-thioglucose injected mice. Proc Soc Exp Biol Med 90:240-244.
33. Miki N, Ono M, Asakawa-Yasumoto K, Aoki T, Murata Y, Ishituka Y, Demura H, Sasaki F. 1994. Characterization and localization of mouse hypothalamic growth hormone-releasing factor and effect of gold thioglucose-induced hypothalamic lesions. J Neuroendocrinol 6:71-78.
34. Oomura Y, Kimura K, Ooyama H, Maeno T, Iki M, Kuniyoshi M. 1964. Reciprocal activities of the ventromedial and lateral hypothalamic areas of cats. Science 143:484-485.
35. Pelletier G, Leclerc R, Saavedra JM, Brownstein MJ, Vaudry H, Ferland L, Labrie F. 1980. Distribution of beta-lipotropin (beta-LPH), adrenocorticotropin (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH) in the rat brain. I. Origin of the extrahypothalamic fibers. Brain Res 192:433-440.
36. Sahu A. 2004. Minireview: a hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 145:2613-2620.
37. Sawchenko PE, Swanson LW, Grzanna R, Howe PR, Bloom SR, Polak JM. 1985. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241:138-153.
38. Schmidt-Kastner R, Meller D, Bellander BM, Stromberg I, Olson L, Ingvar M. 1993. A one-step immunohistochemical method for detection of blood-brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive labelling in immunohistochemistry. J Neurosci Methods 46:121-132.
39. Schmued LC, Hopkins KJ. 2000. Fluoro-Jade B: a high affinity affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 874:123-130.
40. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. 2000. Central nervous system control of food intake. Nature 404:661-671.
41. Schwartzberg DG, Nakane PK. 1983. ACTH-related peptide containing neurons within the medulla oblongata of the rat. Brain Res 276:351-356.
42. Scott PM, Knigge KM. 1981. Immunocytochemistry of luteinizing hormone-releasing hormone, vasopressin, and corticotropin following deafferentation of the basal hypothalamus of the male rat brain. Cell Tissue Res 219:393-402.
43. Shearer MC, Fawcett JW. 2001. The astrocyte/meningeal cell interface-a barrier to successful nerve regeneration? Cell Tissue Res 305:267-273.
44. Ueda S, Nishimura M, Takahashi H, Yoshimura M, Kawata M. 1991. Immunohistochemical study of the neuropeptide-Y immunoreactivity in the paraventricular nucleus experimental lesions. Biomed Res 12:249-258.
45. Wan HZ, Hulsey MG, Martin RJ. 1998. Intracerebroventricular administration of antisense oligodeoxynucleotide against GLUT2 glucose transporter mRNA reduces food intake, body weight change and glucoprivic feeding response in rats. J Nutr 128:287-291.
46. Wittmann G, Liposits Z, Lechan RM, Fekete C. 2002. Medullary adrenergic neurons contribute to the neuropeptide Y-ergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the rat. Neurosci Lett 324:69-73.
47. Young JK. 1988. A glial toxin reduces effects of gold thioglucose on the hypothalamus and area postrema. Brain Res Bull 20:97-104.
48. Young JK. 1989. The glial drug methionine sulfoximine reduces goldthioglucose lesions in mice. Brain Res Bull 22:929-936.
49. Young JK. 1992. Hypothalamic lesions increase neuronal immunoreactivity for neuropeptide Y. Brain Res Bull 29:375-380.
50. Young JK, McKenzie JC. 2004. GLUT2 immunoreactivity in Gomori-positive astrocytes of the hypothalamus. J Histochem Cytochem 52:1519-1524.
51. Young JK, McKenzie JC, Brady LS, Herkenham M. 1994. Hypothalamic lesions increase levels of neuropeptide Y mRNA in the arcuate nucleus of mice. Neurosci Lett 165:13-17.
52. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.