Identification and characterization of msa (SA 1233), a gene involved in expression of SarA and several virulence factors in Staphylococcus aureus

Microbiology

Volumn 152, Issue 9, 2006, Pages 2559-2572

  Sambanthamoorthy, Karthik ^a   Smeltzer, Mark S ^b   Elasri, Mohamed O ^a  

^a The University of Southern Mississippi   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; BINDING PROTEIN; CARBOXYLASE; COLD SHOCK PROTEIN; HEMOLYSIN; MEMBRANE PROTEIN; METALLOPROTEINASE; PROTEIN A; SERINE PROTEINASE; VIRULENCE FACTOR;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CONTROLLED STUDY; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MUTATION; STAPHYLOCOCCUS AUREUS; TRANS-ACTIVATORS; VIRULENCE; VIRULENCE FACTORS;

STAPHYLOCOCCUS AUREUS;

EID: 33748803897     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.29071-0     Document Type: Article

References (59)

1. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. J. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25, 3389-3402.
2. Arvidson, S. & Tegmark, K. (2001). Regulation of virulence determinants in Staphylococcus aureus. Int J Med Microbiol 291, 159-170.
3. Bayer, M. G., Heinrichs, J. H. & Cheung, A. L. (1996). The molecular architecture of the sar locus in Staphylococcus aureus. J Bacteriol 178, 4563-4570.
4. Beenken, K. E., Blevins, J. S. & Smeltzer, M. S. (2003). Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun 71, 4206-4211.
5. Bischoff, M., Entenza, J. M. & Giachino, P. (2001). Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus. J Bacteriol 183, 5171-5179.
6. Blevins, J. S., Gillaspy, A. F., Rechtin, T. M., Hurlburt, B. K. & Smeltzer, M. S. (1999). The staphylococcal accessory regulator (sar) represses transcription of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner. Mol Microbiol 33, 317-326.
7. Blevins, J. S., Beenken, K. E., Elasri, M. O., Hurlburt, B. K. & Smeltzer, M. S. (2002). Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun 70, 470-480.
8. Blevins, J. S., Elasri, M. O., Allmendinger, S. D., Beenken, K. E., Skinner, R. A., Thomas, J. R. & Smeltzer, M. S. (2003). Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect Immun 71, 516-523.
9. Booth, M. C., Cheung, A. L., Hatter, K. L., Jett, B. D., Callegan, M. C. & Gilmore, M. S. (1997). Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis. Infect Immun 65, 1550-1556.
10. Bronner, S., Monteil, H. & Prevost, G. (2004). Regulation of virulence determinants in Staphylococcus aureus: complexity and applications. FEMS Microbiol Rev 28, 183-200.
11. Cassat, J. E., Dunman, P. M., McAleese, F., Murphy, E., Projan, S. J. & Smeltzer, M. S. (2005). Comparative genomics of Staphylococcus aureus musculoskeletal isolates. J Bacteriol 187, 576-592.
12. Chakrabarti, S. K. & Misra, T. K. (2000). SarA represses agr operon expression in a purified in vitro Staphylococcus aureus transcription system. J Bacteriol 182, 5893-5897.
13. Chan, P. F. & Foster, S. J. (1998a). The role of environmental factors in the regulation of virulence-determinant expression in Staphylococcus aureus 8325-4. Microbiology 144, 2469-2479.
14. Chan, P. F. & Foster, S. J. (1998b). Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus. J Bacteriol 180, 6232-6241.
15. Cheung, A. L., Yeaman, M. R., Sullam, P. M., Witt, M. D. & Bayer, A. S. (1994). Role of the sar locus of Staphylococcus aureus in induction of endocarditis in rabbits. Infect Immun 62, 1719-1725.
16. Cheung, A. L., Bayer, M. G. & Heinrichs, J. H. (1997). sar genetic determinants necessary for transcription of RNAII and RNAIII in the agr locus of Staphylococcus aureus. J Bacteriol 179, 3963-3971.
17. Cheung, A. L., Bayer, A. S., Zhang, G., Gresham, H. & Xiong, Y. O. (2004). Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol Med Microbiol 40, 1-9.
18. Chien, Y., Manna, A. C. & Cheung, A. L. (1998). SarA level is a determinant of agr activation in Staphylococcus aureus. Mol Microbiol 30, 991-1001.
19. Chien, Y., Manna, A. C., Projan, S. J. & Cheung, A. L. (1999). SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J Biol Chem 274, 37169-37176.
20. Dunman, P. M., Murphy, E., Haney, S. & 7 other authors (2001). Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci. J Bacteriol 183, 7341-7353.
21. Francis, K. P., Joh, D., Bellinger-Kawahara, C., Hawkinson, M. J., Purchio, T. F. & Contag, P. R. (2000). Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct. Infect Immun 68, 3594-3600.
22. Gillaspy, A. F., Hickmon, S. G., Skinner, R. A., Thomas, J. R., Nelson, C. L. & Smeltzer, M. S. (1995). Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis. Infect Immun 63, 3373-3380.
23. Gillaspy, A. F., Lee, C. Y., Sau, S., Cheung, A. L. & Smeltzer, M. S. (1998). Factors affecting the collagen binding capacity of Staphylococcus aureus. Infect Immun 66, 3170-3178.
24. Goerke, C., Campana, S., Bayer, M. G., Doring, G., Botzenhart, K. & Wolz, C. (2000). Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro. Infect Immun 68, 1304-1311.
25. Heinrichs, J. H., Bayer, M. G. & Cheung, A. L. (1996). Characterization of the sar locus and its interaction with agr in Staphylococcus aureus. J Bacteriol 178, 418-423.
26. Hirokawa, T., Boon-Cheeng, S. & Mitaku, S. (1998). SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14, 378-379.
27. B modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J Bacteriol 184, 5457-5467.
28. Janzon, L. & Arvidson, S. (1990). The role of the delta-lysin gene (hld) in the regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus. EMBO J 9, 1391-1399.
29. Jones, C. L. & Khan, S. A. (1986). Nucleotide sequence of the enterotoxin B gene from Staphylococcus aureus. J Bacteriol 166, 29-33.
30. Karlsson, A., Saravia-Otten, P., Tegmark, K., Morfeldt, E. & Arvidson, S. (2001). Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases. Infect Immun 69, 4742-4748.
31. Katzif, S., Danavall, D., Bowers, S., Balthazar, J. T. & Shafer, W. M. (2003). The major cold shock gene, cspA, is involved in the susceptibility of Staphylococcus aureus to an antimicrobial peptide of human cathepsin G. Infect Immun 71, 4304-4312.
32. Kullik, I., Giachino, P. & Fuchs, T. (1998). Deletion of the alternative sigma factor sigmaB in Staphylococcus aureus reveals its function as a global regulator of virulence genes. J Bacteriol 180, 4814-4820.
33. Kyte, J. & Doolittle, R. F. (1982). A simple method for displaying the hydropathic character of a protein. J Mol Biol 157, 105-132.
34. Lindsay, J. A. & Foster, S. J. (1999). Interactive regulatory pathways control virulence determinant production and stability in response to environmental conditions in Staphylococcus aureus. Mol Gen Genet 262, 323-331.
35. Manna, A. C., Bayer, M. G. & Cheung, A. L. (1998). Transcriptional analysis of different promoters in the sar locus in Staphylococcus aureus. J Bacteriol 180, 3828-3836.
36. Marchler-Bayer, A. & Bryant, S. H. (2004). CD-Search: protein domain annotations on the fly. Nucleic Acids Res 32, W327-W331.
37. McAleese, F. M., Walsh, E. J., Sieprawska, M., Potempa, J. & Foster, T. J. (2001). Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease. J Biol Chem 276, 29969-29978.
38. McCallum, N., Bischoff, M., Maki, H., Wada, A. & Berger-Bachi, B. (2004). TcaR, a putative MarR-like regulator of sarS expression. J Bacteriol 186, 2966-2972.
39. McGavin, M. J., Zahradka, C., Rice, K. & Scott, J. E. (1997). Modification of the Staphylococcus aureus fibronectin binding phenotype by V8 protease. Infect Immun 65, 2621-2628.
40. Morfeldt, E., Tegmark, K. & Arvidson, S. (1996). Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus. Mol Microbiol 21, 1227-1237.
41. Nilsson, I. M., Bremell, T., Ryden, C., Cheung, A. L. & Tarkowski, A. (1996). Role of the staphylococcal accessory gene regulator (sar) in septic arthritis. Infect Immun 64, 4438-4443.
42. Novick, R. P. (1990). The staphylococcus as a molecular genetic system. In Molecular Biology of the Staphylococci, pp. 1-37. Edited by R. P. Novick. New York: VCH Publishers.
43. Novick, R. P. (2003). Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 48, 1429-1449.
44. Novick, R. P., Ross, H. F., Projan, S. J., Kornblum, J., Kreiswirth, B. & Moghazeh, S. (1993). Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J 12, 3967-3975.
45. Rechtin, T. M., Gillaspy, A. F., Schumacher, M. A., Brennan, R. G., Smeltzer, M. S. & Hurlburt, B. K. (1999). Characterization of the SarA virulence gene regulator of Staphylococcus aureus. Mol Microbiol 33, 307-316.
46. Rice, K. C., Patton, T., Yang, S. J., Dumoulin, A., Bischoff, M. & Bayles, K. W. (2004). Transcription of the Staphylococcus aureus cid and lrg murein hydrolase regulators is affected by sigma factor B. J Bacteriol 186, 3029-3037.
47. Rossi, J., Bischoff, M., Wada, A. & Berger-Bachi, B. (2003). MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation. Antimicrob Agents Chemother 47, 2558-2564.
48. Schmidt, K. A., Manna, A. C. & Cheung, A. L. (2003). SarT influences sarS expression in Staphylococcus aureus. Infect Immun 71, 5139-5148.
49. Sifri, C. D., Begun, J., Ausubel, F. M. & Calderwood, S. B. (2003). Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun 71, 2208-2217.
50. Smeltzer, M. S., Hart, M. E. & Iandolo, J. J. (1993). Phenotypic characterization of xpr, a global regulator of extracellular virulence factors in Staphylococcus aureus. Infect Immun 61, 919-925.
51. Snodgrass, J. L., Mohamed, N., Ross, J. M., Sau, S., Lee, C. Y. & Smeltzer, M. S. (1999). Functional analysis of the Staphylococcus aureus collagen adhesin B domain. Infect Immun 67, 3952-3959.
52. Somerville, G. A., Chaussee, M. S., Morgan, C. I., Fitzgerald, J. R., Dorward, D. W., Reitzer, L. J. & Musser, J. M. (2002). Staphylococcus aureus aconitase inactivation unexpectedly inhibits post-exponential-phase growth and enhances stationary-phase survival. Infect Immun 70, 6373-6382.
53. Sterba, K. M., Mackintosh, S. G., Blevins, J. S., Hurlburt, B. K. & Smeltzer, M. S. (2003). Characterization of Staphylococcus aureus SarA binding sites. J Bacteriol 185, 4410-4417.
54. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F. & Higgins, D. G. (1997). The CLUSTAL_C windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25, 4876-4882.
55. Valle, J., Toledo-Arana, A., Berasain, C., Ghigo, J. M., Amorena, B., Penades, J. R. & Lasa, I. (2003). SarA and not sigmaB is essential for biofilm development by Staphylococcus aureus. Mol Microbiol 48, 1075-1087.
56. Wiltshire, M. D. & Foster, S. J. (2001). Identification and analysis of Staphylococcus aureus components expressed by a model system of growth in serum. Infect Immun 69, 5198-5202.
57. Wolz, C., Pohlmann-Dietze, P., Steinhuber, A., Chien, Y. T., Manna, A., van Wamel, W. & Cheung, A. (2000). Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol Microbiol 36, 230-243.
58. Yamanaka, K. (1999). Cold shock response in Escherichia coli. J Mol Microbiol Biotechnol 1, 193-202.
59. Yanisch-Perron, C., Vieira, J. & Messing, J. (1985). Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33, 103-119.