Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells

Annals of Biomedical Engineering

Volumn 34, Issue 8, 2006, Pages 1247-1258

  Cochran, David M ^a   Fukumura, Dai ^a   Ancukiewicz, Marek ^a   Carmeliet, Peter ^b   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cancer; Hypoxia; Mathematical modeling; Stem cell biology; Tissue mimetic culture

Indexed keywords

HYPOXIA; STEM CELL BIOLOGY; TISSUE-MIMETIC CULTURE;

CELL CULTURE; MATHEMATICAL MODELS; METABOLISM; NUTRITION; PARAMETER ESTIMATION; TUMORS;

GLUCOSE;

GLUCOSE; OXYGEN;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOMIMETICS; CELL CULTURE; CELL PROLIFERATION; COMPUTER SIMULATION; CYTOLOGY; HUMAN; KINETICS; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PHYSIOLOGY; STEM CELL; TISSUE CULTURE TECHNIQUE;

ANIMALS; BIOMIMETICS; CELL PROLIFERATION; CELLS, CULTURED; COMPUTER SIMULATION; GLUCOSE; HUMANS; KINETICS; METABOLIC CLEARANCE RATE; MODELS, BIOLOGICAL; OXYGEN; STEM CELLS; TISSUE CULTURE TECHNIQUES;

EID: 33748799706     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-006-9134-4     Document Type: Article

References (30)

1. Acker, H., G. Holtermann, J. Carlsson, and T. Nederman. Methodological aspects of microelectrode measurements in cellular spheroids. Adv. Exp. Med. Biol. 159:445-462, 1983.
2. Aisenberg, A. C. The Glycolysis and Respiration of Tumors. New York: Academic Press, 1961.
3. 2. Am. Statistician 48:113-117, 1994.
4. Balin, A. K., B. P. Goodman, H. Rasmussen, and V. J. Cristofalo. The effect of oxygen tension on the growth and metabolism of WI-38 cells. J. Cell Physiol. 89:235-249, 1976.
5. Balis, U. J., K. Behnia, B. Dwarakanath, S. N. Bhatia, S. J. Sullivan, M. L. Yarmush, and M. Toner. Oxygen consumption characteristics of porcine hepatocytes. Metab. Eng. 1:49-62, 1999.
6. Carmeliet, P., Y. Dor, J. M. Herbert, D. Fukumura, K. Brusselmans, M. Dewerchin, M. Neeman, F. Bono, R. Abramovitch, P. Maxwell, C. J. Koch, P. Ratcliffe, L. Moons, R. K. Jain, D. Collen, E. Keshert, and E. Keshet. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490, 1998.
7. Casciari, J. J., S. V. Sotirchos, and R. M. Sutherland. Mathematical modelling of microenvironment and growth in EMT6/Ro multicellular tumour spheroids. Cell Prolif. 25:1-22, 1992.
8. Casciari, J. J., S. V. Sotirchos, and R. M. Sutherland. Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J. Cell Physiol. 151:386-394, 1992.
9. Deen, W. M. Analysis of Transport Phenomena. New York: Oxford University Press, 1998.
10. Foy, B. D., A. Rotem, M. Toner, R. G. Tompkins, and M. L. Yarmush. A device to measure the oxygen uptake rate of attached cells: Importance in bioartificial organ design. Cell Transplant 3:515-527, 1994.
11. Fuchs, E., T. Tumbar, and G. Guasch. Socializing with the neighbors: Stem cells and their niche. Cell 116:769-778, 2004.
12. Geng, Y. J. Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure. Ann. N. Y. Acad Sci. 1010:687-697, 2003.
13. 2 fields inside cellular spheroids by aid of finite element method. In: Oxygen Transport to Tissue, edited by H. I. Bicher and D. F. Bruley. New York: Plenum Press, 1983, pp. 481-486.
14. Guarino, R. D., L. E. Dike, T. A. Haq, J. A. Rowley, J. B. Pitner, and M. R. Timmins. Method for determining oxygen consumption rates of static cultures from microplate measurements of pericellular dissolved oxygen concentration. Biotechnol. Bioeng. 86:775-787, 2004.
15. Helmlinger, G., M. Endo, N. Ferrara, L. Hlatky, and R. K. Jain. Formation of endothelial cell networks. Nature 405:139-141, 2000.
16. 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation. Nat. Med. 3:177-182, 1997.
17. Hlatky, L., and E. L. Alpen. Two-dimensional diffusion limited system for cell growth. Cell Tissue Kinet. 18:597-611, 1985.
18. Hlatky, L., R. K. Sachs, and E. L. Alpen. Joint oxygen-glucose deprivation as the cause of necrosis in a tumor analog. J. Cell Physiol. 134:167-178, 1988.
19. Li, C. K. The glucose distribution in 9L rat brain multicell tumor spheroids and its effect on cell necrosis. Cancer 50:2066-2073, 1982.
20. Marusic, M., Z. Bajzer, J. P. Freyer. and S. Vuk-Pavlovic. Analysis of growth of multicellular tumour spheroids by mathematical models. Cell Prolif. 27:73-94, 1994.
21. Mueller-Klieser, W., J. P. Freyer, and R. M. Sutherland. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids. Br. J. Cancer 53:345-353, 1986.
22. Ramirez-Bergeron, D. L., and M. C. Simon. Hypoxia-inducible factor and the development of stem cells of the cardiovascular system. Stem Cells 19:279-286, 2001.
23. Romanko, M. J., R. Rola, J. R. Fike, F. G. Szele, M. L. Dizon, R. J. Felling, C. Y. Brazel, and S. W. Levison. Roles of the mammalian subventricular zone in cell replacement after brain injury. Prog. Neurobiol. 74:77-99, 2004.
24. Thews, G., and H. Hutten. Biophysics of respiratory gas transport. In: Biophysics, edited by W. Hoppe, H. Lohmann, and H. Ziegler. Berlin: Springer-Verlag, 1983, 12.16:503-514.
25. 2 measurements by phosphorescence decay method. Am. J. Physiol. 265:H1434-1438, 1993.
26. Tziampazis, E., and A. Sambanis. Modeling of cell culture processes. Cytotechnology 14:191-204, 1994.
27. Tziampazis, E., and A. Sambanis. Tissue engineering of a bioartificial pancreas: Modeling the cell environment and device function. Biotechiiol. Prog. 11:115-126, 1995.
28. Vanderkooi, J. M., G. Maniara, T. J. Green, and D. F. Wilson. An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J. Biol. Chem. 262:5476-5482, 1987.
29. Wodnicka, M., R. D. Guarino, J. J. Hemperly, M. R. Timmins, D. Stilt, and J. B. Pitner. Novel fluorescent technology platform for high throughput cytotoxicity and proliferation assays. J. Biomol. Screw 5:141-152, 2000.
30. Yarmush, M. L., M. Toner, J. C. Dunn, A. Rotem, A. Hubel, and R. G. Tompkins. Hepatic tissue engineering. Development of critical technologies. Ann. N. Y. Acad Sci. 665:238-252, 1992.