Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain

Molecular Pain

Volumn 2, Issue , 2006, Pages

  Inoue, Makoto ^a   Yamaguchi, Asuka ^a   Kawakami, Megumi ^a   Chun, Jerold ^b   Ueda, Hiroshi ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b Department of Molecular Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXOENZYME C3; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDIC ACID RECEPTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NERVE CELL; NERVE FIBER C; NEUROPATHIC PAIN; NEUROTRANSMISSION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL NERVE; SPINAL PAIN;

ANIMALS; BOTULINUM TOXINS; IMMUNOHISTOCHEMISTRY; INJECTIONS, SPINAL; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, KNOCKOUT; NERVE FIBERS, UNMYELINATED; NEURALGIA; PERIPHERAL NERVOUS SYSTEM; POSTERIOR HORN CELLS; RECEPTORS, LYSOPHOSPHATIDIC ACID; RHOA GTP-BINDING PROTEIN; SCIATIC NERVE; SPINAL CORD; SUBSTANCE P;

EID: 33748754869     PISSN: 17448069     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-8069-2-25     Document Type: Article

References (23)

1. Dubner R: Neuronal plasticity in the spinal cord medullary dorsal horn: a possible role in central pain mechanisms. In: Pain and central nervous system disease (Casey KL ed), Raven Press New York 1991:143-155.
2. Woolf CJ, Shortland P, Coggeshall RE: Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 1992, 355(6355):75-78.
3. Woolf CJ, Mannion RJ: Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 1999, 353(9168):1959-1964.
4. Doubell TP, R.J. M, C.J. W: The dorsal horn: state-dependent sensory processing, plasticity and the generation of pain. In: Textbook of Pain Fourth Edition PD Wall and R Melzack (Eds), Churchill Livingstone London 1999:165-181.
5. Woolf CJ, Salter MW: Neuronal plasticity: increasing the gain in pain. Science 2000, 288(5472):1765-1769.
6. Ueda H: Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacol Ther 2006, 109(1-2):57-77.
7. Ueda H, Rashid MH: Molecular mechanism of neuropathic pain. Drug News Perspect 2003, 16(9):605-613.
8. Castro-Lopes JM, Coimbra A, Grant G, Arvidsson J: Ultrastructural changes of the central scalloped (C1) primary afferent endings of synaptic glomeruli in the substantia gelatinosa Rolandi of the rat after peripheral neurotomy. J Neurocytol 1990, 19(3):329-337.
9. Eichhoitz T, Jalink K, Fahrenfort I, Moolenaar WH: The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem J 1993, 291 (Pt 3):677-680.
10. Fukushima N, Ishii I, Contos JJ, Weiner JA, Chun J: Lysophospholipid receptors. Annu Rev Pharmacol Toxicol 2001, 41:507-534.
11. Fukushima N, Ye X, Chun J: Neurobiology of lysophosphatidic acid signaling. Neuroscientist 2002, 8(6):540-550.
12. Ishii I, Fukushima N, Ye X, Chun J: Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 2004, 73:321-354.
13. Kranenburg O, Poland M, van Horck FP, Drechsel D, Hall A, Moolenaar WH: Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol Biol Cell 1999, 10(6):1851-1857.
14. Chun J, Rosen H: Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Curr Pharm Des 2006, 12(2):161-171.
15. Gardell SE, Dubin AE, Chun J: Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med 2006, 12(2):65-75.
16. Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H: Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med 2004, 10(7):712-718.
17. Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16(2):109-110.
18. Rashid MH, Inoue M, Kondo S, Kawashima T, Bakoshi S, Ueda H: Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain. J Pharmacol Exp Ther 2003, 304(3):940-948.
19. Inoue M, Rashid MH, Kawashima T, Matsumoto M, Maeda T, Kishioka S, Ueda H: The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals. Brain Res Bull 2003, 60(3):275-281.
20. Malmberg AB, Basbaum AI: Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain 1998, 76(1-2):215-222.
21. Rashid MH, Inoue M, Matsumoto M, Ueda H: Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice. J Pharmacol Exp Ther 2004, 308(3):1158-1164.
22. Renback K, Inoue M, Ueda H: Lysophosphatidic acid-induced, pertussis toxin-sensitive nociception through a substance P release from peripheral nerve endings in mice. Neurosci Lett 1999, 270(1):59-61.
23. Renback K, Inoue M, Yoshida A, Nyberg F, Ueda H: Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission. Brain Res Mol Brain Res 2000, 75(2):350-354.