Bone repair of rabbit mandibular transsection using rhBMP-2 and atelocollagen gel

European Journal of Medical Research

Volumn 11, Issue 8, 2006, Pages 355-358

  Kimura, Akihiro ^a   Watanabe, T ^a   Shimizu, T ^a   Okafuji, N ^a   Mori, R ^a   Furusawa, K ^a   Kawai, T ^b   Hasegawa, H ^a   Kawakami, T ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Atelocollagen; Histopathology; Mandibular transsection; Rabbit; rhBMP 2

Indexed keywords

ATELOCOLLAGEN; POLYGLACTIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TITANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT; BONE MATURATION; BONE PLATE; BONE REMODELING; BONE SCREW; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; EXPERIMENTAL MODEL; HISTOPATHOLOGY; JAW DISEASE; MALE; MANDIBLE RECONSTRUCTION; NONHUMAN; OSSIFICATION; RABBIT; SPINDLE CELL; TRABECULAR BONE;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; COLLAGEN; DRUG CARRIERS; GELS; HUMANS; LACTIC ACID; MANDIBLE; MODELS, BIOLOGICAL; OSTEOGENESIS; POLYGLYCOLIC ACID; POLYMERS; RABBITS; RECOMBINANT PROTEINS; TIME FACTORS; TITANIUM; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME;

EID: 33748714167     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Lee SC, Shea M, Battle A, Kozitza K, Ron E, Turek T, Schaub RG, Hayes WC (1994) Healing of large segmental defects in rat femurs is aided by rhBMP-2 in PLGA. J Biom Mater Res 28:1149-1156.
2. King GN, Cruchley AT, Wozney JM, Hughes FJ (1997) Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. J Dent Res 76: 1460-1470.
3. Huang KK, Shen C, Chiang CY, Hsieh YD, Fu E (2005) Effects of bone morphogenetic protein-6 on periodontal wound healing in a fenestration defect of rats. J Periodont Res 40: 1-10.
4. Maki F, Murata M, Eitajo H, Sato D, Taira H, Arisue M (2000) Bone healing large mandibular defects without periosteum in adult rabbits: A new application of collagenous sponge for bone regeneration. J Hard Tissue Biol 9: 56-62.
5. Wikesjo UME, Sorensen RG, Kinoshita A, Li XJ, Wozney JM (2004) Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 31: 662-670.
6. Welch RD, Jones AL, Bucholz RW, Reinert CM, Tjia JS, Pierce WA, Wozney JM, Li XJ (1998) Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model. J Bone Miner Res 13: 1483-1490.
7. Cheung LK, Zhang Q (2004) Healing of maxillary alveolus in transport distraction osteogenesis for partial maxillectomy. J Oral Maxillofac Surg 62: 66-72.
8. Marukawa E, Asahina I, Oda M, Seto I, Alam MI, Enomoto S (2001) Bone regeneration using recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar defects of primate mandibles. Br J Oral Maxillofac Surg 39:452-459.
9. Nagao H, Tachikawa N, Miki T, Oda M, Mori M, Takahashi K, Enomoto S (2002) Effect of recombinant human bone morphogenetic protein-2 on bone formation in alveolar ridge defects in dogs. Int J Oral Maxillofac Surg 31:66-72.
10. Boyne PJ, Nakamura A, Shabahang S (1999) Evaluation of the long-term effect of function on rhBMP-2 regenerated hemimandibulectomy defects. Br J Oral Maxillofac Surg 37:344-352.
11. Okafuji N, Shimizu T, Watanabe T, Kimura A, Kurihara S, Arai Y, Furusawa K, Hasegawa H, Kawakami T (2006) Three dimensional observation of reconstruction course of rabbit experimental mandibular defect with rhBMP-2 and atelocollagen gel. Eur J Med Res 11(8): 351-354.
12. Murata M, Maki F, Sato D, Shibata T and Arisue M (2000) Bone augmentation by onlay implant using recombinant human BMP-2 and collagen on adult rat skull without periosteum. Clin Oral Impl Res 11:289-295.
13. Bouxsein BML, Turek TJ, Blake CA, Augusta DD, Li X, Stevens M, Seeherman HJ, Wozney JM (2001) Recombinat human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg 83: 1219-1230.
14. Luppen CA, Blake CA, Ammirati KM, Stevens ML, Seeherman HJ, Wozney JM, Bouxsein ML (2002) Recombinant human morphogenetic protein-2 enhances osteotomy healing in glucocorticoid treated rabbits. J Bone Miner Res 17: 301-310.
15. Takayuki A, Izumi Y, Kazuhiro T, Jinichi F (2002) Effects of latency period in a rabbit mandibular distraction ostegenesis. Oral Maxillofac Surg 39: 71-75.
16. Kawakami T, Hiraoka BY, Kawai T, Takei N, Hasegawa H and Eda S (1999) Expression of transforming growth factor-beta peptide and its mRNA in chondrocytes in the early phase of BMP-induced heterotopic "transchondroid bone formation". Med Sci Res 27:419-421.
17. Kawakami T, Kawai T, Kimura A, Hasegawa H, Tsujigiwa H, Gunduz M, Nagatsuka H, Nagai N (2001) Characteristics of bone morphogenetic protein-induced chondroid bone: histological, immunohistochemical and in situ hybridization examinations. J Int Med Res 29: 480-487.