Relevance of neutrophils in the murine model of haemolytic uraemic syndrome: Mechanisms involved in Shiga toxin type 2-induced neutrophilia

Clinical and Experimental Immunology

Volumn 146, Issue 1, 2006, Pages 76-84

  Fernandez, G C ^a,b   Lopez, M F ^a   Gomez, S A ^a   Ramos, M V ^a   Bentancor, L V ^a   Fernandez Brando, R J ^a   Landoni, V I ^a   Dran, G I ^b   Meiss, R ^a   Isturiz, M A ^a   Palermo, M S ^a  

^a ACADEMIA NACIONAL DE MEDICINA   (Argentina)

^b INST DE INVEST HEMATOLOGICAS   (Argentina)

Author keywords

Depletion; HUS; Neutrophilia; PMN; Stx2

Indexed keywords

VEROTOXIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; HEMOLYTIC UREMIC SYNDROME; KIDNEY INJURY; LEUKOCYTOSIS; MALE; MOUSE; MYELOID PROGENITOR CELL; MYELOPOIESIS; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; SURVIVAL;

ANIMALS; BONE MARROW CELLS; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; HEMOLYTIC-UREMIC SYNDROME; LEUKOCYTOSIS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEUTROPHILS; RABBITS; SHIGA TOXIN 2; SHIGA-LIKE TOXIN II;

EID: 33748707858     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2006.03155.x     Document Type: Article

References (38)

1. Paton JC, Paton AW. Pathogenesis and diagnosis of Shiga toxin-producing Escherichia coli infections. Clin Microbiol Rev 1998; 11:450-79.
2. Remuzzi G, Rossi EC. The hemolytic uremic syndrome. Int J Artif Organs 1985; 8:171-4.
3. Milford D, Taylor CM, Rafaat F, Halloran E, Dawes J. Neutrophil elastases and haemolytic uraemic syndrome. Lancet 1989; 2:1153.
4. Fitzpatrick MM, Shah V, Trompeter RS, Dillon MJ, Barratt TM. Interleukin-8 and polymorphoneutrophil leucocyte activation in hemolytic uremic syndrome of childhood. Kidney Int 1992; 42:951-6.
5. Forsyth KD, Simpson AC, Fitzpatrick MM, Barratt TM, Levinsky RJ. Neutrophil-mediated endothelial injury in haemolytic uraemic syndrome. Lancet 1989; 2:411-4.
6. Walters MD, Matthei IU, Kay R, Dillon MJ, Barratt TM. The polymorphonuclear leucocyte count in childhood haemolytic uraemic syndrome. Pediatr Nephrol 1989; 3:130-4.
7. Coad NA, Marshall T, Rowe B, Taylor CM. Changes in the postenteropathic form of the hemolytic uremic syndrome in children. Clin Nephrol 1991; 35:10-6.
8. Opdenakker G, Fibbe WE, Van Damme J. The molecular basis of leukocytosis. Immunol Today 1998; 19:182-9.
9. Karpman D, Hakansson A, Perez MT, Isaksson C, Carlemalm E, Caprioli A, Svanborg C. Apoptosis of renal cortical cells in the hemolytic-uremic syndrome: in vivo and in vitro studies. Infect Immun 1998; 66:636-44.
10. Dran GI, Fernandez GC, Rubel CJ, Bermejo E, Gomez S, Meiss R, Isturiz MA, Palermo MS. Protective role of nitric oxide in mice with Shiga toxin-induced hemolytic uremic syndrome. Kidney Int 2002; 62:1338-48.
11. Fernandez GC, Rubel C, Dran G, Gomez S, Isturiz MA, Palermo MS. Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome. Clin Immunol 2000; 95:227-34.
12. Gomez SA, Fernandez GC, Camerano G et al. Endogenous glucocorticoids modulate neutrophil function in a murine model of haemolytic uraemic syndrome. Clin Exp Immunol 2005; 139:65-73.
13. Duner KI. A new kinetic single-stage Limulus amoebocyte lysate method for the detection of endotoxin in water and plasma. J Biochem Biophys Meth 1993; 26:131-42.
14. Cronkite EP, Fliedner TM, Bond VP, Rubini JR. Dynamics of hemopoietic proliferation in man and mice studied by H3-thymidine incorporation into DNA. Ann NY Acad Sci 1959; 77:803-20.
15. Coligan J, Knisblek A, Margulies D, Shevach E, Warren S. In vitro assays for mouse lymphocyte function. In: Coligan J, Knisblek A, Margulies D, eds. Current protocols in immunology. National Institute of Health, USA. New York: Wiley & Sons, 1994: 3.20.3-4.
16. Mulligan MS, Jones ML, Bolanowski MA et al. Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody. J Immunol 1993; 150:5585-95.
17. Palermo M, Alves-Rosa F, Rubel C et al. Pretreatment of mice with lipopolysaccharide (LPS) or IL-1beta exerts dose-dependent opposite effects on Shiga toxin-2 lethality. Clin Exp Immunol 2000; 119:77-83.
18. Sugatani J, Igarashi T, Munakata M et al. Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2. Thromb Res 2000; 100:61-72.
19. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med 1989; 320:365-76.
20. Lentsch AB, Ward PA. Regulation of inflammatory vascular damage. J Pathol 2000; 190:343-8.
21. van Setten PA, van Hinsbergh VW, van den Heuvel LP et al. Monocyte chemoattractant protein-1 and interleukin-8 levels in urine and serum of patents with hemolytic uremic syndrome. Pediatr Res 1998; 43:759-67.
22. Inward CD, Howie AJ, Fitzpatrick MM, Rafaat F, Milford DV, Taylor CM. Renal histopathology in fatal cases of diarrhoea-associated haemolytic uraemic syndrome. British Association for Paediatric Nephrology. Pediatr Nephrol 1997; 11:556-9.
23. Pavia AT, Nichols CR, Green DP et al. Hemolytic-uremic syndrome during an outbreak of Escherichia coli O157: H7 infections in institutions for mentally retarded persons: clinical and epidemiologic observations. J Pediatr 1990, 116: 544-51.
24. Milford DV, Staten J, MacGreggor I, Dawes J, Taylor CM, Hill FG. Prognostic markers in diarrhoea-associated haemolytic-uraemic syndrome: initial neutrophil count, human neutrophil elastase and von Willebrand factor antigen. Nephrol Dial Transplant 1991; 6:232-7.
25. Fitzpatrick MM, Shah V, Filler G, Dillon MJ, Barratt TM. Neutrophil activation in the haemolytic uraemic syndrome: free and complexed elastase in plasma. Pediatr Nephrol 1992; 6:50-3.
26. Frevert CW, Warner AE, Kobzik L. Defective pulmonary recruitment of neutrophils in a rat model of endotoxemia. Am J Respir Cell Mol Biol 1994; 11:716-23.
27. Schleiffenbaum B, Fehr J, Odermatt B, Sperb R. Inhibition of leukocyte emigration induced during the systemic inflammatory reaction in vivo is not due to IL-8. J Immunol 1998; 161:3631-8.
28. Ley K, Baker JB, Cybulsky MI, Gimbrone MA, Jr., Luscinskas FW. Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J Immunol 1993; 151:6347-57.
29. Hechtman DH, Cybulsky MI, Fuchs HJ, Baker JB, Gimbrone MA, Jr. Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol 1991; 147:883-92.
30. Luu NT, Rainger GE, Nash GB. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J Immunol 2000; 164:5961-9.
31. Didsbury JR, Uhing RJ, Tomhave E, Gerard C, Gerard N, Snyderman R. Receptor class desensitization of leukocyte chemoattractant receptors. Proc Natl Acad Sci USA 1991; 88:11564-8.
32. Tomhave ED, Richardson RM, Didsbury JR, Menard L, Snyderman R, Ali H. Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation. J Immunol 1994; 153:3267-75.
33. Ali H, Richardson RM, Haribabu B, Snyderman R. Chemoattractant receptor cross-desensitization. J Biol Chem 1999; 274:6027-30.
34. Laterveer L, Zijlmans JM, Lindley IJ, Hamilton MS, Willemze R, Fibbe WE. Improved survival of lethally irradiated recipient mice transplanted with circulating progenitor cells mobilized by IL-8 after pretreatment with stem cell factor. Exp Hematol 1996; 24:1387-93.
35. Van Damme J, Van Beeumen J, Opdenakker G, Billiau A. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J Exp Med 1988; 167:1364-76.
36. Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, Van Damme J. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J Immunol 1993; 150:1000-10.
37. Pruijt JF, Fibbe WE, Laterveer L et al. Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9). Proc Natl Acad Sci USA 1999; 96:10863-8.
38. Pruijt JF, Verzaal P, van Os R et al. Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice. Proc Natl Acad Sci USA 2002; 99:6228-33.