Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred High and Low Alcohol Sensitive selectively bred rat lines

Psychopharmacology

Volumn 188, Issue 3, 2006, Pages 343-354

  Radcliffe, Richard A ^a,b   Bludeau, Pequita ^a   Asperi, William ^a   Fay, Tina ^a   Deng, X S ^a   Erwin, V Gene ^a,b   Deitrich, Richard A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Congenic; Ethanol; Genetics; QTL

Indexed keywords

ALCOHOL; NEUROTENSIN RECEPTOR;

ALCOHOL BLOOD LEVEL; ALCOHOL TOLERANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 2; CHROMOSOME 5; CHROMOSOME MAP; CONGENIC STRAIN; CONTROLLED STUDY; CROSS BREEDING; FEMALE; GENE MAPPING; GENETIC ANALYSIS; GENOTYPE; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; RIGHTING REFLEX; ROTAROD TEST;

ALCOHOLISM; ANIMALS; BREEDING; CHROMOSOME MAPPING; CHROMOSOMES, MAMMALIAN; ETHANOL; FEMALE; GENOTYPE; INJECTIONS, INTRAPERITONEAL; MALE; MESENCEPHALON; NUCLEUS ACCUMBENS; PHENOTYPE; PUTAMEN; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED STRAINS; RECEPTORS, NEUROTENSIN; REFLEX; ROTAROD PERFORMANCE TEST; SEX FACTORS; TIME FACTORS;

EID: 33748668782     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0512-2     Document Type: Article

References (66)

1. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F (2003) The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet 4:911-916
2. Allan AM, Harris RA (1986) Gamma-aminobutyric acid and alcohol actions: neurochemical studies of long sleep and short sleep mice. Life Sci 39:2005-2015
3. Allan AM, Huidobro-Toro JP, Bleck V, Harris RA (1987) Alcohol and the GABA receptor-chloride channel complex of brain. Alcohol Alcohol Suppl 1:643-646
4. Belknap JK, Mitchell SR, O'Toole LA, Helms ML, Crabbe JC (1996) Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains. Behav Genet 26:149-160
5. Bennett B, Beeson M, Gordon L, Carosone-Link P, Johnson TE (2002) Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: Mapping with interval-specific congenic, recombinant lines. Alcohol Clin Exp Res 26:1615-1624
6. Campbell AD, Erwin VG (1993) Chronic ethanol administration downregulates neurotensin receptors in long- and short-sleep mice. Pharmacol Biochem Behav 45:95-106
7. Christensen SC, Johnson TE, Markel PD, Clark VJ, Fulker DW, Corley RP, Collins AC, Wehner JM (1996) Quantitative trait locus analyses of sleep-times induced by sedative-hypnotics in LSXSS recombinant inbred strains of mice. Alcohol Clin Exp Res 20:543-550
8. Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138:963-971
9. Crabbe JC, Gallaher ES, Phillips TJ, Belknap JK (1994a) Genetic determinants of sensitivity to ethanol in inbred mice. Behav Neurosci 108:186-195
10. Crabbe JC, Belknap JK, Buck KJ, Metten P (1994b) Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Alcohol Alcohol Suppl 2:67-71
11. Darvasi A (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18:19-24
12. Deitrich RA, Spuhler KP, Baker RC, Erwin VG (1988) Development and characteristics of rats selectively bred for sensitivity to ethanol. In: Kuriyama K, Takada A, Ishii H (eds) Biomedical and social aspects of alcohol and alcoholism. Elsevier Science B.V., pp 419-422
13. Deitrich RA, Draski LJ, Baker RC (1994) Effect of pentobarbital and gaseous anesthetics on rats selectively bred for ethanol sensitivity. Pharmacol Biochem Behav 47:721-725
14. Demarest K, McCaughran J Jr, Mahjubi E, Cipp L, Hitzemann R (1999) Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2. J Neurosci 19:549-561
15. Draski LJ, Spuhler KP, Erwin VG, Baker RC, Deitrich RA (1992) Selective breeding of rats differing in sensitivity to the effects of acute ethanol administration. Alcohol Clin Exp Res 16:48-54
16. Draski LJ, Deitrich RA, Menez JF (1997) Phenobarbital sensitivity in HAS and LAS rats before and after chronic administration of ethanol. Pharmacol Biochem Behav 57:651-657
17. Erwin VG, Korte A (1988) Brain neurotensin receptors in mice bred for differences in sensitivity to ethanol. Alcohol 5:195-201
18. Erwin VG, Jones BC (1989) Comparison of neurotensin levels, receptors and actions in LS/Ibg and SS/Ibg mice. Peptides 10:435-440
19. Erwin VG, Jones BC (1993) Genetic correlations among ethanol-related behaviors and neurotensin receptors in long sleep (LS) x short sleep (SS) recombinant inbred strains of mice. Behav Genet 23:191-196
20. Erwin VG, Heston WDW, McClearn GE, Deitrich RA (1976) Effect of hypnotics on mice genetically selected for sensitivity to ethanol. Pharmacol Biochem Behav 4:679-683
21. Erwin VG, Draski LJ, Deitrich RA (1996) Neurotensin levels and receptors in HAS and LAS rat brains: effects of ethanol. Pharmacol Biochem Behav 54:525-532
22. Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC (1997) Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects. J Pharmacol Exp Ther 280:911-918
23. Erwin VG, Gehle VM, Davidson KL, Radcliffe RA (2001) Confirmation of correlations and common quantitative trait loci between neurotensin receptor density and hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 25:1699-1707
24. Finn PR, Pihl RO (1987) Men at risk for alcoholism: the effect of alcohol on cardiovascular response to unavoidable shock. J Abnorm Psychol 96:230-236
25. Flint J, Valdar W, Shifman S, Mott R (2005) Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6:271-286
26. Garlow SJ, Boone E, Kinkead B, Nemeroff CB (2006) Genetic analysis of the hypothalamic neurotensin system. Neuropsychopharmacology 31:535-543
27. Gianoulakis C, Beliveau D, Angelogianni P, Meaney M, Thavundayil J, Tawar V, Dumas M (1989) Different pituitary β-endorphin and adrenal cortisol response to ethanol in individuals with high and low risk for future development of alcoholism. Life Sci 45:1097-1109
28. Gill K, Desaulniers N, Desjardins P, Lake K (1998) Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci. Mamm Genome 9:929-935
29. Heath AC, Madden PA, Bucholz KK, Dinwiddie SH, Slutske WS, Bierut LJ, Rohrbaugh JW, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1999) Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol Med 29:1069-1081
30. Keir WJ, Deitrich RA (1990) Development of central nervous system sensitivity to ethanol and pentobarbital in short- and long-sleep mice. J Pharmacol Exp Ther 254:831-835
31. King AC, Houle T, de Wit H, Holdstock L, Schuster A (2002) Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Exp Res 26:827-835
32. Kitabgi P, Carraway R, Van Rietschoten J, Granier C, Morgat JL, Menez A, Leeman SE, Freychet P (1977) Neurotensin: specific binding to synaptic membranes from rat brain. Proc Natl Acad Sci USA 74:1846-1850
33. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
34. Lander ES, Green P, Abrahamson J, Barlow A, Daley M, Lincoln S, Newburg L (1987) MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1:174-181
35. Liu Y, Deitrich R (1998) Role of GABA in the actions of ethanol in rats selectively bred for ethanol sensitivity. Pharmacol Biochem Behav 60:793-801
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275
37. Lundquist F (1959) The determination of ethyl alcohol in blood and tissue. Methods Biochem Anal 7:217-251
38. Mackay TF (2001) The genetic architecture of quantitative traits. Annu Rev Genet 35:303-339
39. Manly KF, Cudmore RH, Meer JM (2001) Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12:930-932
40. Markel PD, Fulker DW, Bennett B, Corley RP, DeFries JC, Erwin VG, Johnson TE (1996) Quantitative trait loci for ethanol sensitivity in the LSXSS recombinant inbred strains: interval mapping. Behav Genet 26:447-458
41. Martin NG (1988) Twin studies of alcohol consumption, metabolism, and sensitivity. Aust Drug Alcohol Rev 7:9-12
42. McClearn GE, Kakihana R (1981) Selective breeding for ethanol sensitivity: short-sleep and long-sleep mice. In: McClearn GE, Deitrich RA, Erwin VG (eds) Development of animal models as pharmacogenetic tools. NIAAA Research Monograph, Rockville, Maryland, pp 147-159
43. Morzorati SL, Ramchandani VA, Flury L, Li TK, O'Connor S (2002) Self-reported subjective perception of intoxication reflects family history of alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res 26:1299-1306
44. Newlin DB, Thomson JB (1990) Alcohol challenge with sons of alcoholics: a critical review and analysis. Psychol Bull 108:383-402
45. Newlin DB, Thomson JB (1991) Chronic tolerance and sensitization to alcohol in sons of alcoholics. Alcohol Clin Exp Res 15:399-405
46. Newlin DB, Thomson JB (1999) Chronic tolerance and sensitization to alcohol in sons of alcoholics: II. Replication and reanalysis. Exp Clin Psychopharmacol 7:234-243
47. Owens JC, Bennett B, Johnson TE (2001) Evidence that the Lore-1 region specifies ethanol-induced activation in addition to sedative/ hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 25:1551-1557
48. Palmer MR, Wang Y, Fossom LH, Spuhler KP (1987) Genetic correlation of ethanol-induced ataxia and cerebellar Purkinje neuron depression among inbred strains and selected lines of rats. Alcohol Clin Exp Res 11:494-501
49. Palmer MR, Harlan JT, Spuhler K (1992) Genetic covariation in low alcohol-sensitive and high alcohol-sensitive selected lines of rats: behavioral and electrophysiological sensitivities to the depressant effects of ethanol and the development of acute neuronal tolerance to ethanol in situ at generation eight. J Pharmacol Exp Ther 260:879-886
50. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, San Diego
51. Peirce JL, Derr R, Shendure J, Kolata T, Silver LM (1998) A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mamm Genome 9:942-948
52. Peterson JB, Pihl RO, Gianoulakis C, Conrod P, Finn PR, Stewart SH, LeMarquand DG, Bruce KR (1996) Ethanol-induced change in cardiac and endogenous opiate function and risk for alcoholism. Alcohol Clin Exp Res 20:1542-1552
53. Radcliffe RA, Jones BC, Erwin VG (1998) Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LS x SS recombinant inbred strains. Behav Genet 28:39-47
54. Radcliffe RA, Bohl ML, Lowe MV, Cycowski CS, Wehner JM (2000) Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. Alcohol Clin Exp Res 24:1335-1342
55. Radcliffe RA, Erwin VG, Draski L, Hoffmann S, Edwards J, Deng XS, Bludeau P, Fay T, Lundquist K, Asperi W, Deitrich RA (2004) Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Alcohol Clin Exp Res 28:1796-1804
56. Rat Genome Data (2005) Rat Genome Database Web Site, Medical College of Wisconsin, Milwaukee, Wisconsin. Available at http://rgd.mcw.edu/. November, 2005
57. Schuckit MA (1984) Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry 41:879-884
58. Schuckit MA (2002) Vulnerability factors for alcoholism. In: Davis K (ed) Neuropsychopharmacology: the fifth generation of progress. Lippincott Williams & Wilkins, Baltimore, pp 1399-1411
59. Seiger A, Sorensen SM, Palmer MR (1983) Cerebellar role in the differential ethanol sensitivity of long sleep and short sleep mice. Pharmacol Biochem Behav 18(Suppl 1):495-499
60. Sorensen S, Palmer M, Dunwiddie TV, Hoffer B (1980) Electrophysiological correlates of ethanol-induced sedation in differentially sensitive lines of mice. Science 210:1143-1145
61. Spuhler K, Hoffer B, Weiner N, Palmer M (1982) Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in mice. Pharmacol Biochem Behav 17:569-578
62. Spuhler K, Deitrich RA, Baker RC (1990) Selective breeding of rats differing in sensitivity to the hypnotic effects of acute ethanol administration. In: Deitrich RA, Pawlowski AA (eds) Initial sensitivity to alcohol. National Institute on Alcohol Abuse and Alcoholism, Rockville Maryland, pp 87-102
63. Terenina-Rigaldie E, Moisan MP, Colas A, Beauge F, Shah KV, Jones BC, Mormede P (2003) Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines. Pharmacogenetics 13:543-554
64. Viken RJ, Rose RJ, Morzorati SL, Christian JC, Li T-K (2003) Subjective intoxication in response to alcohol challenge: heritability and covariation with personality, breath alcohol level, and drinking history. Alcohol Clin Exp Res 27:795-803
65. Wang S, Basten CJ, Zeng Z-B (2006) Windows QTL Cartographer 2.5. Department of Statistics, North Carolina State University, Raleigh, North Carolina
66. Wilson JR, Erwin VG, McClearn GE, Plomin R, Johnson RC, Ahern FM, Cole RE (1984) Effects of ethanol: II. Behavioral sensitivity and acute behavioral tolerance. Alcohol Clin Exp Res 8:366-374