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The time for deprotonation must be <5 minutes; otherwise, significant decomposition of the cyanohydrin part was observed. Likewise, the use of KHMDS as the base and hexamethyl phosphoramide (HMPA) as a cosolvent were detrimental.
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46
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33748651132
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The configuration of the cyanohydrin center C31 has not been determined.
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33748648949
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note
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NMR spectroscopic analysis suggests that the compound mainly exists as a pyranoid hemiacetal analogous to that found in 35.
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