Spirastrellolide A: Revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A

Organic Letters

Volumn 6, Issue 15, 2004, Pages 2607-2610

  Williams, David E ^a   Lapawa, Marshall ^b   Feng, Xidong ^c   Tarling, Tamsin ^a   Roberge, Michel ^a   Andersen, Raymond J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Department of Chemistry ^*

^c WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROLIDE; PHOSPHATASE; SPIRASTRELLOLIDE A; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CROSS COUPLING REACTION; DRUG INHIBITION; DRUG ISOLATION; DRUG SELECTIVITY; MOLECULE;

ANIMALS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MACROLIDES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHOPROTEIN PHOSPHATASE; PORIFERA;

EID: 4043120611     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0490983     Document Type: Article

References (4)

1. Williams, D. E.; Roberge, M.; Van Soest, R.; Andersen, R. J. J. Am. Chem. Soc. 2003, 125, 5296-5297.
2. Roberge, M.; Cinel, B.; Anderson, H. J.; Lim, L.; Jiang, X.; Xu, L.; Kelly, M. T.; Andersen, R. J. Cancer Res. 2000, 60, 5052-5058.
3. Rychnovsky, S. D.; Rogers, B.; Guang Yang, G. J. Org. Chem. 1993, 58, 3511-3515.
4. McCluskey, A.; Sim, A. T. R.; Sakoff, J. A. J. Med. Chem. 2002, 45, 1151-1175.