Taxol and tau overexpression induced calpain-dependent degradation of the microtubule-destabilizing protein SCG10

Experimental Neurology

Volumn 202, Issue 1, 2006, Pages 152-160

  Vega, Irving E ^a   Hamano, Tadanori ^a   Propost, Josh A ^a   Grenningloh, Gabriele ^b   Yen, Shu Hui ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Calpain; Degradation; Microtubules; SCG10; Tau; Taxol

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALPAIN; CASPASE INHIBITOR; EPOXOMICIN; LACTACYSTIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE STABILIZING PROTEIN SCG10; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NOCODAZOLE; PACLITAXEL; ROSCOVITINE; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL POLARITY; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MICROTUBULE; NEUROBLASTOMA CELL; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; RAT;

ANIMALS; BLOTTING, WESTERN; CALPAIN; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; LEUPEPTINS; MEMBRANE PROTEINS; NEUROBLASTOMA; PACLITAXEL; RATS; TAU PROTEINS; TRANSFECTION; TUBULIN MODULATORS;

EID: 33748631287     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.05.026     Document Type: Article

References (26)

1. Antonsson B., Kassel D.B., DiPaolo G., Lutjens R., Riederer B.M., and Grenningloh G. Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect of phosphorylation site mutants on microtubule-destabilizing activity. J. Biol. Chem. 273 (1998) 8439-8446
2. Buèe L., Bussiére T., Buèe-Scherrer V., Delacorte A., and Hof P.R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33 (2000) 95-130
3. Croall D.E., and DeMartino G.N. Calcium-activated neutral protease (calpain) system: structure, function and regulation. Physiol. Rev. 71 (1991) 813-847
4. Dent E.W., and Gertler F.B. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron 40 (2003) 209-227
5. DeTure M., Ko L.W., Easson C., and Yen S.H. Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau. Am. J. Pathol. 161 (2002) 1711-1721
6. DiPaolo G., Lutjens R., Pellier V., Stimpson S.A., Beuchat M.H., Catsicas S., and Grenningloh G. Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. J. Biol. Chem. 272 (1997) 5175-5182
7. Feinstein S.C., and Wilson L. Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. Biochim. Biophys. Acta 1739 (2005) 268-279
8. Grenningloh G., Soehrman S., Bondallaz P., Ruchti E., and Cadas H. Role of the microtubule destabilizing proteins SCG10 and Stathmin in neuronal growth. J. Neurobiol. 58 (2004) 60-69
9. Kar S., Fan J., Smith M.J., Goedert M., and Amos L.A. Repeat motifs of tau binds to the insides of microtubules in the absence of Taxol. EMBO J. 22 (2003) 70-77
10. Kim J.A., Mitsukawa K., Yamada M.K., Nishiyama N., Matsuki N., and Ikegaya Y. Cytoskeleton disruption causes apoptotic degeneration of dentate granule cells in hippocampal slice cultures. Neuropharmacology 42 (2002) 1109-1118
11. Ko L.W., DeTure M., Sahara N., Chihab R., Vega I.E., and Yen S.H. Recent advances in experimental modeling of the assembly of tau filaments. Biochim. Biophys. Acta 1739 (2005) 125-139
12. Kornitzer D., and Ciechanover A. Modes of regulation of ubiquitin-mediated protein degradation. J. Cell. Physiol. 182 (2000) 1-11
13. Lee V.M.-Y., Goedert M., and Trojanowski J.Q. Neurodegenerative disorders. Annu. Rev. Neurosci. 24 (2001) 1121-1159
14. Lutjens R., Igarashi M., Pallier V., Blasey H., DiPaolo G., Ruchti E., Pfulg C., Staple J.K., Catsicas S., and Grenningloh G. Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles. Eur. J. Neurosci. 12 (2000) 2224-2234
15. Maekawa S., Morii H., Kumanogoh H., Sano M., Naruse Y., Sokawa Y., and Mori N. Localization of neuronal growth-associated, microtubule-destabilizing factor SCG10 in brain-derived raft membrane microdomains. J. Biochem. (Tokio) 129 (2001) 691-697
16. Michaelis M.L., Ansar S., Chen Y., Reiff E.R., Seyb K.I., Himes R.H., Audus K.L., and Georg G.I. {beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents. J. Pharmacol. Exp. Ther. 16 (2004) 1-30
17. Mitchison T., and Kirschner M.W. Dynamic instability of microtubule growth. Nature 312 (1984) 237-242
18. Peng H., Derrick B.E., and Martinez Jr. J.L. Identification of upregulated SCG10 mRNA expression associated with late-phase long-term potentiation in the rat hippocampal Schaffer-CA1 pathway in vivo. J. Neurosci. 23 (2003) 6617-6626
19. Riederer B.M., Pellier V., Antonsson B., DiPaolo G., Stimpson S.A., Lütjens R., Catsicas S., and Grenningloh G. Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 741-745
20. Rouzier R., Rajan R., Wagner P., Hess K.R., Gold D.L., Stec J., Ayers M., Ross J.S., Zhang P., Buhholz T.A., Kuerer H., Green M., Arun B., Hortobagyi G.N., Symmans W.F., and Pusztai L. Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8315-8320
21. Samsonov A., Yu J.Z., Rasenick M., and Popov S.V. Tau interaction with microtubules in vivo. J. Cell Sci. 117 (2004) 6129-6141
22. Sato K., and Kawashima S. Calpain function in the modulation of signal transduction molecules. J. Biol. Chem. 382 (2001) 743-751
23. Wang T.H., Wang H.S., and Soong Y.K. Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer 88 (2000) 2620-2628
24. Wang M.S., Davis A.A., Culver D.G., Wang Q., Powers J.C., and Glass J.D. Calpain inhibition protects against Taxol-induced sensory neuropathy. Brain 127 (2004) 671-679
25. Zatz M., and Startling A. Calpains and disease. N. Engl. J. Med. 352 (2005) 2413-2423
26. Zhang B., Maiti A., Shively S., Lakhani F., McDonald-Jones G., Bruce J., Lee E.B., Xie S.X., Joyce S., Li C., Toleikis P.M., Lee V.M.-Y., and Trojanowski J.Q. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 227-231