Identification of human T-cell epitopes and highly immunogenic analog peptides on the non-typeable Haemophilus influenzae P6 outer membrane protein

Clinical Immunology

Volumn 121, Issue 1, 2006, Pages 90-99

  Ishida, Yoshiya ^a   Abe, Yusuke ^a   Yanai, Mitsuru ^a   Kobayashi, Hiroya ^a   Harabuchi, Yasuaki ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Non typeable Haemophilus Influenzae; P6 outer membrane protein; T cell epitopes

Indexed keywords

BACTERIAL VACCINE; EPITOPE; GLUTAMINYLTYROSYLASPARAGYLISOLEUCYLALANYLLEUCYLGLYCYLGLUTAMYLARGININE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN P6; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL INFECTION; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG IDENTIFICATION; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE TYPE P6; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOGENICITY; IMMUNOPHARMACOLOGY; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; OTITIS; PRIORITY JOURNAL; VACCINE PRODUCTION;

ADULT; AMINO ACID SEQUENCE; BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE, TRANSFORMED; EPITOPES, T-LYMPHOCYTE; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 33748602903     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.06.005     Document Type: Article

References (42)

1. Murphy T.F., and Apicella M.A. Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection. Rev. Infect. Dis. 9 (1987) 1-15
2. Sethi S., and Murphy T.F. Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin. Microbiol. Rev. 14 (2001) 336-363
3. Murphy T.F., Bartos L.C., Rice P.A., Nelson M.B., Dudas K.C., and Apicella M.A. Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody. J. Clin. Invest. 78 (1986) 1020-1027
4. Murphy T.F., Nelson M.B., Dudas K.C., Mylotte J.M., and Apicella M.A. Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein. J. Infect. Dis. 152 (1985) 1300-1307
5. Murphy T.F., Bartos L.C., Campagnari A.A., Nelson M.B., and Apicella M.A. Antigenic characterization of the P6 protein of nontypable Haemophilus influenzae. Infect. Immun. 54 (1986) 774-779
6. Yamanaka N., and Faden H. Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children. J. Pediatr. 122 (1993) 212-218
7. Yamanaka N., and Faden H. Local antibody response to P6 of nontypable Haemophilus influenzae in otitis-prone and normal children. Acta Oto-laryngol. 113 (1993) 524-529
8. Harabuchi Y., Faden H., Yamanaka N., Duffy L., Wolf J., and Krystofik D. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. Tonawanda/Williamsville Pediatrics. J. Infect. Dis. 170 (1994) 862-866
9. Harabuchi Y., Faden H., Yamanaka N., Duffy L., Wolf J., and Krystofik D. Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization. J. Pediatr. 124 (1994) 193-198
10. Hotomi M., Saito T., and Yamanaka N. Specific mucosal immunity and enhanced nasopharyngeal clearance of nontypeable Haemophilus influenzae after intranasal immunization with outer membrane protein P6 and cholera toxin. Vaccine 16 (1998) 1950-1956
11. Kodama S., Suenaga S., Hirano T., Suzuki M., and Mogi G. Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization. Infect. Immun. 68 (2000) 2294-2300
12. Hotomi M., Yamanaka N., Shimada J., Suzumoto M., Ikeda Y., Sakai A., Arai J., and Green B. Intranasal immunization with recombinant outer membrane protein P6 induces specific immune responses against nontypeable Haemophilus influenzae. Int. J. Pediatr. Otorhinolaryngol. 65 (2002) 109-116
13. Abe Y., Murphy T.F., Sethi S., Faden H.S., Dmochowski J., Harabuchi Y., and Thanavala Y.M. Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 165 (2002) 967-971
14. Kodama H., and Faden H. Cellular immunity to the P6 outer membrane protein of nontypeable Haemophilus influenzae. Infect. Immun. 63 (1995) 2467-2472
15. Kodama H., Faden H., Harabuchi Y., Kataura A., Bernstein J.M., and Brodsky L. Cellular immune response of adenoidal and tonsillar lymphocytes to the P6 outer membrane protein of non-typeable Haemophilus influenzae and its relation to otitis media. Acta Otolaryngol. 119 (1999) 377-383
16. Ada G. Vaccines and vaccination. N Engl. J. Med. 345 (2001) 1042-1053
17. Migliorini P., Betschart B., and Corradin G. Malaria vaccine: immunization of mice with a synthetic T cell helper epitope alone leads to protective immunity. Eur. J. Immunol. 23 (1993) 582-585
18. Olive C., Clair T., Yarwood P., and Good M.F. Protection of mice from group A streptococcal infection by intranasal immunisation with a peptide vaccine that contains a conserved M protein B cell epitope and lacks a T cell autoepitope. Vaccine 20 (2002) 2816-2825
19. Barenkam S.J., and St Geme III J.W. Identification of surface-exposed B-cell epitopes on high molecular-weight adhesion proteins of nontypeable Haemophilus influenzae. Infect. Immun. 64 (1996) 3032-3037
20. Novotny L.A., Jurcisek J.A., Pichichero M.E., and Bakaletz L.O. Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae. Infect. Immun. 68 (2000) 2119-2128
21. Hayman W.A., Toth I., Flinn N., Scanlon M., and Good M.F. Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology. Immunol. Cell Biol. 80 (2002) 178-187
22. Beck-Sickinger A.G., Rotering H., Wiesmuller K.H., Dorner F., and Jung G. Mapping of antigenic and immunogenic sites of Haemophilus influenzae outer membrane protein P6 using synthetic lipopeptides. Biol. Chem. Hoppe-Seyler. 375 (1994) 173-182
23. Munson Jr. R.S., and Granoff D.M. Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b. Infect. Immun. 49 (1985) 544-549
24. Badr W.H., Loghmanee D., Karalus R.J., Murphy T.F., and Thanavala Y. Immunization of mice with P6 of nontypeable Haemophilus influenzae: kinetics of the antibody response and IgG subclasses. Vaccine 18 (1999) 29-37
25. Karalus R.J., and Murphy T.F. Purification and characterization of outer membrane protein P6, a vaccine antigen of non-typeable Haemophilus influenzae. FEMS Immunol. Med. Microbiol. 26 (1999) 159-166
26. Nelson M.B., Apicella M.A., Murphy T.F., Vankeulen H., Spotila L.D., and Rekosh D. Cloning and sequencing of Haemophilus influenzae outer membrane protein P6. Infect. Immun. 56 (1988) 128-134
27. Pisano M.R., Nicoli J., and Tolou H. Homogeneity of yellow fever virus strains isolated during an epidemic and a post-epidemic period in West Africa. Virus Genes 14 (1997) 225-234
28. Kobayashi H., Wood M., Song Y., Appella E., and Celis E. Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen. Cancer Res. 60 (2000) 5228-5236
29. Abe Y., Kimura S., Kokubo T., Mizumoto K., Uehara M., and Katagiri M. Epitope analysis of birch pollen allergen in Japanese subjects. J. Clin. Immunol. 17 (1997) 485-493
30. Rammensee H.G., Friede T., and Stevanoviic S. MHC ligands and peptide motifs: first listing. Immunogenetics 41 (1995) 178-228
31. Futaki G., Kobayashi H., Sato K., Taneichi M., and Katagiri M. Naturally processed HLA-DR9/DR53 (DRB1*0901/DRB4*0101)-bound peptides. Immunogenetics 42 (1995) 299-301
32. Tana T., Kamikawaji N., Savoie C.J., Sudo T., Kinoshita Y., and Sasazuki T. An HLA-binding-motif-aided peptide epitope library: a novel library design for the screening of HLA-DR4-restricted antigenic peptides recognized by CD4 + T cells. J. Hum. Genet. 43 (1998) 14-21
33. Hashimoto M., Kinoshita T., Yamasaki M., Tanaka H., Imanishi T., Ihara H., Ichikawa Y., and Fukunishi T. Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals. Tissue Antigens 44 (1994) 166-173
34. Mizumoto K., Kimura S., Abe Y., Uehara M., and Katagiri M. [Analysis of T cell epitopes on birch pollen allergen]. Hokkaido Igaku Zasshi 72 (1997) 59-67
35. Hiroi T., Fujihashi K., McGhee J.R., and Kiyono H. Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. Eur. J. Immunol. 25 (1995) 2743-2751
36. Beagley K.W., Eldridge J.H., Kiyono H., Everson M.P., Koopman W.J., Honjo T., and McGhee J.R. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J. Immunol. 141 (1988) 2035-2042
37. Beagley K.W., Eldridge J.H., Lee F., Kiyono H., Everson M.P., Koopman W.J., Hirano T., Kishimoto T., and McGhee J.R. Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J. Exp. Med. 169 (1989) 2133-2148
38. Defrance T., Vanbervliet B., Briere F., Durand I., Rousset F., and Banchereau J. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175 (1992) 671-682
39. Kurono Y., Suzuki M., Mogi G., Yamamoto M., Fujihashi K., McGhee J.R., and Kiyono H. Effects of intranasal immunization on protective immunity against otitis media. Int. J. Pediatr. Otorhinolaryngol. 49 Suppl 1 (1999) S227-S229
40. Marinaro M., Boyaka P.N., Finkelman F.D., Kiyono H., Jackson R.J., Jirillo E., and McGhee J.R. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. J. Exp. Med. 185 (1997) 415-427
41. Joshi M.B., Gam A.A., Boykins R.A., Kumar S., Sacci J., Hoffman S.L., Nakhasi H.L., and Kenney R.T. Immunogenicity of well-characterized synthetic Plasmodium falciparum multiple antigen peptide conjugates. Infect. Immun. 69 (2001) 4884-4890
42. Chai S.K., Clavijo P., Tam J.P., and Zavala F. Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopes. J. Immunol. 149 (1992) 2385-2390