Modulation of endotoxin-stimulated TNF-α gene expression by ketamine and propofol in cultured human whole blood

Anaesthesist

Volumn 50, Issue 7, 2001, Pages 494-499

  Hoff, G ^a   Bauer, I ^a   Larsen, B ^a   Bauer, M ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Anesthesia; Cytokines; Inflammation; Stress response

Indexed keywords

KETAMINE; PROPOFOL; TUMOR NECROSIS FACTOR ALPHA;

ANESTHESIA INDUCTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; HOST RESISTANCE; HUMAN; IMMUNOCOMPETENCE; IMMUNOMODULATION; NORMAL HUMAN;

ANESTHETICS, DISSOCIATIVE; ANESTHETICS, INTRAVENOUS; BLOTTING, NORTHERN; CELLS, CULTURED; DACTINOMYCIN; ENDOTOXINS; HALF-LIFE; HUMANS; KETAMINE; LIPOPOLYSACCHARIDES; NUCLEIC ACID SYNTHESIS INHIBITORS; PROPOFOL; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034918940     PISSN: 00032417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001010100149     Document Type: Article

References (23)

1. Pathophysiologie der sepsis-aktuelle konzepte
2. Anästhesie und perioperative immunfunktion
3. Sir Isaac Newton, sepsis, SIRS, and CARS
4. Effect of anaesthesia on the cytokine responses to abdominal surgery
5. Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
6. Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: A prospective case study
7. Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis
8. Depression of cellular immunity after major surgery
9. Endotoxin desensitization of human mononuclear cells after cardiopulmonary bypass: Role of humoral factors
10. Impaired ex vivo lipopolysaccharide-stimulated whole blood tumor necrosis factor production may identify "septic" intensive care unit patients
11. Increase of interleukin-6 plasma concentration and HLA-DR positive T-lymphocytes after hypotensive anaesthesia with sodium nitroprusside
12. Inhibitory effect of the intravenous anesthetic, ketamine, on rat mesangial cell proliferation
13. The TNF and lymphotoxin promotors
14. Suppression of neutrophil migration and chemiluminescence is due to the sulphur atom in the thiobarbiturate molecule
15. The effects of thiopentone, etomidate, ketamine, and midazolam on several bactericidal functions of polymorphonuclear leukocytes in vitro
16. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood
17. Inflammatory cytokines in major surgery: A functional perspective
18. Opioid-mediated suppression of interferon-γ production by cultured peripheral blood mononuclear cells
19. Anaesthetic agents induce human mononuclear leukocytes to release cytokines
20. Cytokines in anaesthesia
21. Ketamine suppresses endotoxin-induced tumor necrosis factor alpha production in mice
22. A convenient human whole blood culture system for studying the regulation of tumor necrosis factor release by bacterial lipopolysaccharide
23. Mixed agonistic-antagonistic cytokine response in whole blood from patients undergoing abdominal aortic aneurysm repair