Down-regulation of wt1 expression in leukemia cell lines as part of apoptotic effect in arsenic treatment using two compounds

Leukemia and Lymphoma

Volumn 47, Issue 8, 2006, Pages 1629-1638

  Glienke, Wolfgang ^a   Chow, Kai U ^a   Bauer, Nina ^a   Bergmann, Lothar ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Acute promyelocytic leukemia; Arsenic trioxide; Sodium arsenite; WT1

Indexed keywords

ARSENIC TRIOXIDE; ARSENITE SODIUM; KML 001; MESSENGER RNA; PROTEIN BCL 2; PROTEINASE ACTIVATED RECEPTOR 4; TELOMERASE REVERSE TRANSCRIPTASE; WT1 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC CODE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; ARSENITES; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA; OXIDES; SODIUM COMPOUNDS; WT1 PROTEINS;

EID: 33748555528     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190600625398     Document Type: Article

References (37)

1. Kitchin, K. (2001) Recent advances in arsenic carcinogenesis: Modes of action, animal model systems and methylated arsenic metabolites Toxicol Appl Pharmacol, 172, pp. 249-261.
2. Sun, H and Ma, L and Hu, X and Zhang, T. (1992) Ai-Lin I treated 32 cases of acute promyelocytic leukemia Chin J Integrat Chin Western Med, 12, pp. 170-172.
3. 3 induces NB4 cell apoptosis with down regulation of Bcl-2 expression and modulation of PML-RARα/PML proteins Blood, 88, pp. 1052-1061.
4. Chen, G and Shi, X and Tang, W. (1997) Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): As2O3 exerts dose-dependent dual effects on APL cells Blood, 89, pp. 3345-3353.
5. Warrell, R, Jr and de The, H and Wang, Z and Degos, L. (1993) Acute promyelocytic leukemia N Engl J Med, 329, pp. 177-189.
6. Huang, M and Ye, Y and Chen, S and Chai, J and Lu, J and Zhao, L and (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia Blood, 72, pp. 567-572.
7. Castaigne, S and Chomienne, C and Daniel, M and Ballerini, P and Berger, R and Fenaux, P and Degos, L. (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results Blood, 76, pp. 1704-1709.
8. Grignani, F and Fagioli, M and Alcalay, M and Longo, L and Pandolfi, P and Donti, E and (1994) Acute promyelocytic leukemia: From genetics to treatment Blood, 83, pp. 10-25.
9. Frankel, S and Eardley, A and Lauwers, G and Weiss, M and Warrell, R, Jr. (1992) The retinoic acid syndrome in acute promyelocytic leukemia Ann Intern Med, 117, pp. 292-296.
10. Delva, L and Comic, M and Balitrand, N and Guidez, F and Miclea, J and Delmer, A and (1993) Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: Study of in vitro all-trans retinoic acid sensitivity and cellular retinoic acid-binding protein levels in leukemic cell Blood, 82, pp. 2175-2181.
11. Warrell, R, Jr. (1993) Retinoid resistance in acute promyelocytic leukemia. New mechanisms, strategies and implications Blood, 82, pp. 1949-1953.
12. Zhang, T and Schmitt, M and Mumford, J. (2003) Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro Carcinogenesis, 24, pp. 1811-1817.
13. Sells, S and Wood, D and Joshi-Barve, S and Muthukumar, S and Jacob, R and Crist, S and (1994) Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells Cell Growth Differ, 5, pp. 457-466.
14. Sells, S and Han, S and Muthukkumar, S and Maddiwar, N and Johnstone, R and Boghaert, E and (1997) Expression and function of the leucine zipper protein Par-4 in apoptosis Mol Cell Biol, 17, pp. 3823-3832.
15. Qiu, G and Ahmed, M and Sells, S and Mohiuddin, M and Weinstein, M and Rangnekar, V. (1997) Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumours consistent with down-regulation of Bcl-2 by Par-4 Oncogene, 18, pp. 623-631.
16. Diaz-Meco, M and Municio, M and Frutos, S and Sanchez, P and Lozano, J and Sanz, L and Moscat, J. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C Cell, 86, pp. 777-786.
17. Kawai, T and Akira, S and Reed, J. (2003) ZIP kinase triggers apoptosis from nuclear PML oncogenic domains Mol Cell Biol, 23, pp. 6174-6186.
18. Karakas, T and Miething, C and Maurer, U and Weidmann, E and Ackermann, H and Hoelzer, D and Bergmann, L. (2002) The co expression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia Leukemia, 16, pp. 846-854.
19. Glienke, W and Seil, I and Bauer, N and Bergmann, L. (2005) Small interfering RNA-mediated gene silencing of WT1 in leukemia cell lines Proc Am Soc Clin Oncol (ASCO). Abstract #3199
20. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients Blood, 89, pp. 3354-3360.
21. Soignet, S and Maslak, P and Wang, Z and Jhanwar, S and Calleja, E and Dardashti, D and (1998) Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide N Engl J Med, 339, pp. 1341-1348.
22. Puccetti, E and Güller, S and Orleth, A and Brüggenolte, N and Hoelzer, D and Ottmann, O and Ruthardt, M. (2000) BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity Cancer Res, 60, pp. 3409-3413.
23. Boehrer, S and Chow, K and Puccetti, E and Ruthardt, M and Godzisard, S and Krapohl, A and (2001) Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia Hematol J, 2, pp. 103-107.
24. Chou, W and Hawkins, A and Barrett, J and Griffin, C and Dang, C. (2001) Arsenic inhibition of telomerase transcription leads to genetic instability J Clin Invest, 108, pp. 1541-1547.
25. Li, J and Liu, S. (2003) Changes of telomerase activity and hTERT mRNA expression in the process of HL-60 cells induced by arsenic sulphide Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 19, pp. 595-597.
26. Kyo, S. (2001) Sp1 cooperate with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT) Nucleic Acids Res, 28, pp. 669-677.
27. Wu, K. (1999) Direct activation of TERT transcription by c-MYC Nat Genet, 21, pp. 220-224.
28. Bergmann, L and Miething, C and Maurer, U and Brieger, J and Karakas, T and Weidmann, E and Hoelzer, D. (1997) High levels of Wilms' tumour gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome Blood, 90, pp. 1217-1225.
29. Bergmann, L and Maurer, U and Weidmann, E. (1997) Wilms' tumor gene expression in acute myeloid leukemias Lymphoma, 25, pp. 435-443.
30. Savli, H and Sirma, S and Nagy, B and Aktan, M and Dincol, G and Ozbek, U. (2003) Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients Exp Mol Med, 35, pp. 454-459.
31. Akiyama, M and Yamada, O and Yanagisawa, T and Fujisawa, K and Eto, Y and Yamada, H. (2006) Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic treated with all-trans retinoic acid Ped Blood Cancer, 46, pp. 506-511.
32. Chou, W and Chen, H and Yu, S and Cheng, L and Yang, P and Dang, C. (2005) Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation Blood, 106, pp. 304-310.
33. Cohen, H and Bossone, S and Zhu, G and McDonald, G and Sukhatme, V. (1997) Sp1 is a critical regulator of the Wilms' tumor-1 gene J Biol Chem, 272, pp. 2901-2913.
34. Hübinger, G and Schmid, M and Linortner, S and Manegold, A and Bergmann, L and Maurer, U. (2001) Ribozyme-mediated cleavage of wt1 transcripts suppresses growth of leukemia cells Exp Haematol, 29, pp. 1226-1235.
35. Yamagami, T and Sugiyama, H and Inoue, K and Ogawa, H and Tatekawa, T and Hirata, M and (1996) Growth inhibition of human leukaemic cells by wt1 antisense oligonucleotides: Implication for the involvement of WT-1 in leukemogenesis Blood, 87, pp. 2878-2884.
36. Algar, E and Khromykh, T and Smith, S and Blackburn, D and Bryson, G and Smith, P. (1996) A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukemia cell lines Oncogene, 12, pp. 1005-1014.
37. Yamagami, T and Ogawa, H and Tamaki, H and Oji, Y and Soma, T and Oka, Y and (1998) Suppression of Wilms' tumour gene (WT1) expression induces G2/ M arrest in leukaemic cells Leuk Res, 22, pp. 383-384.