Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia

Experimental Hematology

Volumn 34, Issue 10, 2006, Pages 1312-1322

  Pontikoglou, Charalampos ^a   Liapakis, George ^a   Pyrovolaki, Katerina ^a   Papadakis, Marios ^a   Bux, Juergen ^b   Eliopoulos, George D ^a   Papadaki, Helen A ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b Institute Springe   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD36 ANTIGEN; CD71 ANTIGEN; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GAMMA INTERFERON; GLYCOPHORIN A; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANEMIA; APOPTOSIS; ARTICLE; BONE MARROW; BURST FORMING UNIT; CELL GROWTH; CELL SURVIVAL; CHRONIC IDIOPATHIC NEUTROPENIA; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROID CELL; ERYTHROPOIESIS; FEMALE; FLOW CYTOMETRY; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MONONUCLEAR CELL; NEUTROPENIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; ANTIGENS, CD; APOPTOSIS; BONE MARROW CELLS; CELL PROLIFERATION; CHRONIC DISEASE; DOWN-REGULATION; ERYTHROID CELLS; ERYTHROPOIESIS; FEMALE; GLYCOPHORIN; HUMANS; INTERFERON TYPE II; MALE; MIDDLE AGED; NEUTROPENIA; RECEPTORS, ERYTHROPOIETIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33748522068     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.05.010     Document Type: Article

References (44)

1. Kyle R.A., and Linman J.W. Chronic idiopathic neutropenia. A newly recognized entity?. N Engl J Med 279 (1968) 1015-1019
2. Dale D.C., Guerry D., Wewerka J.R., Bull J.M., and Chusid M.J. Chronic neutropenia. Medicine (Baltimore) 58 (1979) 128-144
3. Haddy T.B., Rana S.R., and Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count?. J Lab Clin Med 133 (1999) 15-22
4. Papadaki H.A., Palmblad J., and Eliopoulos G.D. Non-immune chronic idiopathic neutropenia of adult: an overview. Eur J Haematol 67 (2001) 35-44
5. Kyle R.A. Natural history of chronic idiopathic neutropenia. N Engl J Med 302 (1980) 908-909
6. *1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. Blood 97 (2001) 580-581
7. Eliopoulos G.D., Meletis J., Fessas P., and Anagnou N.P. Defective CSA-dependent granulopoiesis in patients with chronic neutropenia. Haematologia 23 (1990) 101-109
8. Papadaki H.A., Chatzivassili A., Stefanaki K., Koumaki V., Kanavaros P., and Eliopoulos G.D. Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Ann Hematol 79 (2000) 563-570
9. Papadaki H.A., Eliopoulos A.G., Kosteas T., et al. Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood 101 (2003) 2591-2600
10. Papadaki H.A., and Eliopoulos G.D. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle 2 (2003) 447-451
11. Koumaki V., Papadaki H.A., Stefanaki K., et al. Increased cell apoptosis in bone marrow trephine biopsies and immunomagnetically isolated myeloid progenitor cells in patients with chronic idiopathic neutropenia. Ann Hematol 82 (2003) 641-645
12. Papadaki H.A., Giouremou K., and Eliopoulos G.D. Low frequency of myeloid progenitor cells in chronic idiopathic neutropenia of adults may be related to increased production of TGF-β1 by bone marrow stromal cells. Eur J Haematol 63 (1999) 154-162
13. Papadaki H.A., Stamatopoulos K., Damianaki A., et al. Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. Br J Haematol 128 (2005) 863-867
14. Papadaki H.A., Eliopoulos D.G., Valatas V., and Eliopoulos G.D. Anemia of chronic disease is the more frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. Ann Hematol 80 (2001) 195-200
15. Means R.T., and Krantz S.B. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 80 (1992) 1639-1647
16. Rusten L.S., and Jacobsen S.E. Tumor necrosis factor (TNF)-alpha directly inhibits human erythropoiesis in vitro: role of p55 and p75 TNF receptors. Blood 85 (1995) 989-996
17. Dai C.H., Price J.O., Brunner T., and Krantz S.B. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood 91 (1998) 1235-1242
18. Palmblad J., Papadaki H.A., and Eliopoulos G.D. Acute and chronic neutropenias. What is new?. J Intern Med 250 (2001) 476-491
19. Miller C.B., Jones R.J., Piantadosi S., Abeloff M.D., and Spivak J.L. Decreased erythropoietin response in patients with anemia of cancer. N Engl J Med 322 (1990) 1689-1692
20. Papadaki H.A., Kritikos H.D., Valatas V., Boumpas D.T., and Eliopoulos G.D. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. Blood 100 (2002) 474-482
21. Coutinho L.H., Gilleece M.H., De Wynter E.A., Will A., and Testa N.G. Clonal and long-term cultures using human bone marrow. In: Testa N.G., and Molineux G. (Eds). Haemopoiesis. A practical approach (1993), Oxford University Press, Oxford 75-106
22. Philpott N.J., Turner A.J., Scopes J., et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood 87 (1996) 2244-2251
23. Tennant G.B., Walsh V., Truran L.N., Edwards P., Mills K.I., and Burnett A.K. Abnormalities of adherent layers grown from bone marrow of patients with myelodysplasia. Br J Haematol 111 (2000) 853-862
24. Charbord P. Mediators involved in the control of hematopoiesis by the microenvironment. In: Zon L. (Ed). Hematopoiesis. A developmental approach (2001), Oxford University Press, Inc., New York 702-717
25. Papadaki H.A., Kritikos H.D., Gemetzi C., et al. Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood 99 (2002) 1610-1619
26. Loken M.R., Shah V.O., Dattilio K.L., and Civin C.I. Flow cytometric analysis of human bone marrow: I. Normal erythroid development. Blood 69 (1987) 255-263
27. Greenwalt D.E., Lipsky R.H., Ockenhouse C.F., Ikeda H., Tandon N.N., and Jamieson G.A. Membrane glycoprotein CD36: A review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80 (1992) 1105-1115
28. Papadaki H.A., Marsh J.C., and Eliopoulos G.D. Bone marrow stem cells and stromal cells in autoimmune cytopenias. Leuk Lymphoma 43 (2002) 753-760
29. Krantz S.B. Erythropoietin. Blood 77 (1991) 419-434
30. Barosi G. Inadequate erythropoietin response to anemia: definition and clinical relevance. Ann Hematol 68 (1994) 215-223
31. Cazzola M., Ponchio L., de Benedetti F., et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anaemia associated with systemic-onset juvenile chronic arthritis. Blood 87 (1996) 4824-4830
32. + cells. Exp Hematol 30 (2002) 1238-1247
33. Taniguchi S., Dai C.H., Price J.O., and Krantz S.B. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells. Blood 90 (1997) 2244-2252
34. de Vos S., Brach M.A., Asano Y., et al. Transforming growth factor-beta 1 interferes with the proliferation-inducing activity of stem cell factor in myelogenous leukemia blasts through functional down-regulation of the c-kit proto-oncogene product. Cancer Res 53 (1993) 3638-3642
35. + cells via p55 TNF alpha receptors. Blood 84 (1994) 2506-2514
36. Dubois C.M., Ruscetti F.W., Stankova J., and Keller J.R. Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors. Blood 83 (1994) 3138-3145
37. Broudy V.C., Lin N., Brice M., Nakamoto B., and Papayannopoulou T. Erythropoietin receptor characteristics on primary human erythroid cells. Blood 77 (1991) 2583-2590
38. Papadaki H.A., Pontikoglou C., Stavroulaki E., et al. Soluble c-kit ligand production by bone marrow stromal cells is independent of the degree of neutropenia in patients with chronic idiopathic neutropenia. Ann Hematol 85 (2006) 170-173
39. Besmer P. Kit-ligand-stem cell factor. In: Garland J.M., Quesenberry P.J., and Hilton D.J. (Eds). Colony-stimulating factors: Molecular and cellular biology (1997), Marcel Dekker, New York 369-404
40. Uoshima N., Ozawa M., Kimura S., et al. Changes in c-Kit expression and effects of SCF during differentiation of human erythroid progenitor cells. Br J Haematol 91 (1995) 30-36
41. Selleri C., Sato T., Anderson S., Young N.S., and Maciejewski J.P. Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. J Cell Physiol 165 (1995) 538-546
42. De Maria R., Testa U., Luchetti L., et al. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood 93 (1999) 796-803
43. Jacobsen S.E., Ruscetti F.W., Dubois C.M., and Keller J.R. Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation. J Exp Med 175 (1992) 1759-1772
44. Weiss G., and Goodnough L.T. Anaemia of chronic disease. N Engl J Med 352 (2005) 1011-1023