Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia

British Journal of Haematology

Volumn 128, Issue 6, 2005, Pages 863-876

  Papadaki, Helen A ^a,e   Stamatopoulos, K ^b   Damianaki, A ^a   Gemetzi, C ^a   Anagnostopoulos, A ^b   Papadaki, T ^c   Eliopoulos, A G ^d   Eliopoulos, G D ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b G Papanikolaou Hospital   (Greece)

^c EVANGELISMOS HOSPITAL   (Greece)

^d UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^e UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Chronic neutropenia; Fas ligand; Interferon ; Myelosuppression; T lymphocytes

Indexed keywords

CD38 ANTIGEN; CD69 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE MARROW CELL; BONE MARROW SUPPRESSION; CELL CULTURE; CELL SUBPOPULATION; CHRONIC IDIOPATHIC NEUTROPENIA; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GRANULOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNITY; MAJOR CLINICAL STUDY; MALE; MOLECULAR RECOGNITION; MONONUCLEAR CELL; NEUTROPENIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; AGED; BONE MARROW; CHRONIC DISEASE; CLONE CELLS; FAS LIGAND PROTEIN; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEUTROPENIA; T-LYMPHOCYTES;

EID: 15944413133     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05380.x     Document Type: Article

References (34)

1. Barrett, J., Saunthararajah, Y. & Molldrem, J. (2000) Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology? Seminars in Hematology, 37, 15-29.
2. Coutinho, L.H., Gilleece, M.H., De Wynter, H.A., Will, A. & Testa, N.G. (1993) Clonal and long-term cultures using human bone marrow. In: Haemopoiesis. A Practical Approach (ed. by N.G. Testa & G. Molineux), pp. 75-106. Oxford University Press, Oxford.
3. Dale, D.C. (1991). Neutrophil disorders: Benign, quantitative abnormalities of neutrophils. In: Hematology (ed. by W.J. Williams, E. Beutler, A.J. Erslev & M.A. Lichtman), pp. 807-816. McGraw-Hill Publishing Company, New York, MY.
4. Dale, D.C., Guerry, D., Wewerka, J.R., Bull, J.M. & Chusid, J. (1979) Chronic neutropenia. Medicine (Baltimore), 58, 128-144.
5. Dunbar, C.E. & Saunthararajah, Y. (2000) Myelodysplastic syndromes. In: Bone Marrow Failure Syndromes (ed. by N.S. Young), pp. 69-98. W.B. Saunders Company, Philadelphia, PA.
6. Eliopoulos, G.D., Meletis, J., Fessas, P. & Anagnou, N.P. (1990) Defective CSA-dependent granulopoiesis in patients with chronic idiopathic and drug-induced neutropenia. Haematologia, 23, 101-109.
7. Greenberg, P.L., Mara, B., Steed, S. & Boxer, L. (1980) The chronic idiopathic neutropenia syndrome: correlation of clinical features with in vitro parameters of granulocytopoiesis. Blood, 55, 915-921.
8. Haddy, T.B., Rana, E.R. & Castro, O. (1999) Benign ethnic neutropenia: what is a normal absolute neutrophil count? Journal of Laboratory and Clinical Medicine, 133, 15-22.
9. Hsu, S.M. & Raine, L. (1981) Protein A, avidin and biotin in immunohistochemistry. Journal of Histochemistry and Cytochemistry, 29, 1349-1353.
10. Kitagawa, M., Yamaguchi, S., Takahashi, M., Tanizawa, T., Hirokawa, K. & Kamiyama, R. (1998) Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia, 12, 486-492.
11. Kook, H., Zeng, W., Guibin, C., Kirby, M., Young, N.S. & Maciejewski, J.P. (2001) Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia. Experimental Hematology, 29, 1270-1277.
12. Kyle, R.A. (1980) Natural history of chronic idiopathic neutropenia. The New England Journal of Medicine, 302, 908-909.
13. Kyle, R.A. & Linman, J.W. (1968) Chronic idiopathic neutropenia. A newly recognized entity? The New England Journal of Medicine, 279, 1015-1019.
14. Maciejewski, J.P., Hibbs, J.R., Anderson, S., Katevas, P. & Young, N.S. (1994) Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Experimental Hematology, 22, 1102-1110.
15. Maciejewski, J.P., Selleri, S., Sato, T., Cho, H.J., Keefer, L.K., Nathan, C.F. & Young, N.S. (1995) Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. Journal of Clinical Investigation, 96, 1085-1092.
16. lck in T-cell receptor/CD3-mediated apoptosis and Fas-ligand induction in Jurkat cells. Biochemical and Biophysical Research Communications, 213, 994-1001.
17. Palmblad, J., Papadaki, H.A. & Eliopoulos, G.D. (2001) Acute and chronic neutropenias. What is new? Journal of Internal Medicine, 250, 476-491.
18. Papadaki, H.A. & Eliopoulos, G.D. (2003) The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle, 2, 447-451.
19. Papadaki, H.A., Xylouri, I., Coulocheri, S., Kalmanti, M., Kafatos, A. & Eliopoulos, G.D. (1999a) Prevalence of chronic idiopathic neutropenia of adults among an apparently healthy population living on the island of Crete. Annals of Hematology, 78, 293-297.
20. 1 by bone marrow stromal cells. European Journal of Haematology, 63, 154-162.
21. Papadaki, H.A., Chatzivassili, A., Stefanaki, K., Koumaki, V., Kanavaros, P. & Eliopoulos, G.D. (2000) Morphologically defined myeloid cell compartments, lymphocyte subpopulations, and histological findings of bone marrow in patients with nonimmune chronic idiopathic neutropenia of adults. Annals of Hematology, 79, 563-570.
22. Papadaki, H.A., Palmblad, J. & Eliopoulos, G.D. (2001a) Non-immune chronic idiopathic neutropenia of adult: an overview. European Journal of Haematology, 67, 35-44.
23. Papadaki, H.A., Eliopoulos, D.G., Valatas, V., Eliopoulos, G.D. (2001b) Anemia of chronic disease is the most frequent type of anemia seen in patients with chronic idiopathic neutropenia of adults. Annals of Hematology, 80, 195-200.
24. Papadaki, H.A., Eliopoulos, G.D., Coulocheri, S.A., Spyropoulou, M. & Stavropoulos-Giokas, C. (2001c) Increased frequency of HLA-DRB1*1302 haplotype in patients with nonimmune chronic idiopathic neutropenia of adults. Blood, 97, 580-581.
25. + cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus. British Journal of Haematology, 115, 167-174.
26. Papadaki, H.A., Kritikos, H.D., Gemetzi, C., Koutala, H., Marsh, J.C.W., Boumpas, D.T. & Eliopoulos, G.D. (2002) Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. Blood, 99, 1610-1619.
27. Papadaki, H.A., Eliopoulos, A.G., Kosteas, T., Gemetzi, C., Damianaki, A., Koutala, H., Bux, J. & Eliopoulos, G.D. (2003) Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood, 101, 2591-2600.
28. Rothfuchs, A.G., Gigliotti, D., Palmblad, K., Andersson, U., Wigzell, H. & Rottenberg, M.E. (2001) IFN-alpha, beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. Journal of Immunology, 167, 6453-6461.
29. Selleri, C., Sato, T., Anderson, S., Young, N.S. & Maciejewski, J.P. (1995) Interferon-gamma and tumor necrosis factor-alpha suppress both early and late stages of hematopoiesis and induce programmed cell death. Journal of Cell Physiology, 165, 538-546.
30. Selleri, C., Maciejewski, J.P., Catalano, L., Ricci, P., Andretta, C., Luciano, L. & Rotoli, B. (2002) Effects of cyclosporine on hematopoietic and immune functions in patients with hypoplastic myelodysplasia: in vitro and in vivo studies. Cancer, 95, 1911-1922.
31. van Dongen, J.J., Langerak, A.W., Bruggemann, M., Evans, P.A., Hummel, M., Lavender, F.L., Delabesse, E., Davi, F., Schuuring, E., Garcia-Sanz, R., van Krieken, J.H., Droese, J., Gonzalez, D., Bastard, C., White, H.E., Spaargaren, M., Gonzalez, M., Parreia, A., Smith, J.L., Morgan, G.J., Kneba, M. & MacIntyre, E.A. (2003) Design and standarization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, 17, 2257-2317.
32. Young, N.S. (2000a) Acquired aplastic anemia. In: Bone Marrow Failure Syndromes (ed. by N.S. Young), W.B. Saunders Company, Philadelphia, PA.
33. Young, N.S. (2000b) Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia. Seminars in Hematology, 37, 3-14.
34. Zoumbos, N.C., Gascon, P., Djeu, J.Y., Trost, S.R. & Young, N.S. (1985) Circulating activated suppressor T lymphocytes in aplastic anemia. The New England Journal of Medicine, 312, 257-265.