Racial differences in the response to drugs - Pointers to genetic differences

New England Journal of Medicine

Volumn 344, Issue 18, 2001, Pages 1393-1396

  Wood, A J J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CYTOCHROME P450; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE;

DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EDITORIAL; GENE FREQUENCY; GENETIC POLYMORPHISM; HEART FAILURE; HOSPITALIZATION; HUMAN; PHENOTYPE; PRIORITY JOURNAL; RACE DIFFERENCE; CONGESTIVE HEART FAILURE; ETHNOLOGY; GENETICS; METABOLISM; MORTALITY; NOTE; RACE;

ADRENERGIC ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CARBAZOLES; CONTINENTAL POPULATION GROUPS; CYTOCHROME P-450 ENZYME SYSTEM; ENALAPRIL; HEART FAILURE, CONGESTIVE; HOSPITALIZATION; HUMANS; MORTALITY; PROPANOLAMINES;

EID: 0035799809     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200105033441811     Document Type: Editorial

References (15)

1. Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure
2. Lesser response to angiotensin-converting-enzyme inhibitor therapy in black as compared with white patients with left ventricular dysfunction
3. Racial profiling in medical research
4. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
5. Molecular basis of ethnic differences in drug disposition and response
6. Geographical/interracial differences in polymorphic drug oxidation: Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
7. Stereoselective disposition of carvedilol is determined by CYP2D6
8. Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes
9. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications
10. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer
11. Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure
12. Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure
13. Does angiotensin-converting enzyme polymorphism influence the clinical manifestation and progression of heart failure in patients with dilated cardiomyopathy?
14. The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure
15. Attenuation of isoproterenol-mediated vasodilatation in blacks