House dust mite allergen Der p1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells

International Immunology

Volumn 18, Issue 8, 2006, Pages 1327-1335

  Wong, Chun K ^a   Li, Mandy L Y ^a   Wang, Cheng B ^a,b   Ip, Wai K ^a   Tian, Ya P ^b   Lam, Christopher W K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Medical School of Chinese People's Liberation Army   (China)

Author keywords

Intercellular adhesion molecule; Interleukins; p38 mitogen activated protein kinease; Transcription factor; Tumor necrosis factor

Indexed keywords

CD18 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ASTHMA; ARTICLE; BRONCHUS MUCOSA; CELL ACTIVATION; CELL ADHESION; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DERMATOPHAGOIDES PTERONYSSINUS; DOWN REGULATION; ENZYME ACTIVATION; EOSINOPHIL; EPITHELIUM CELL; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, DERMATOPHAGOIDES; ASTHMA; BRONCHI; CELL ADHESION MOLECULES; COCULTURE TECHNIQUES; CURCUMIN; CYTOKINES; DERMATOPHAGOIDES PTERONYSSINUS; ENZYME ACTIVATION; EOSINOPHILS; EPITHELIAL CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMIDAZOLES; NF-KAPPA B; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; PYROGLYPHIDAE; SULFONES; TH2 CELLS; TRANSCRIPTION FACTOR AP-1;

EID: 33748445862     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl065     Document Type: Article

References (45)

1. Chiappara, G., Gagliardo, R., Siena, A. et al. 2001. Airway remodelling in the pathogenesis of asthma. Curr. Opin. Allergy Clin. Immunol. 1:85.
2. Walsh, G. M. 2001. Eosinophil-epithelial cell interactions: A special relationship? Clin. Exp. Allergy 31:351.
3. Walsh, G. M. 2001. Eosinophil granule proteins and their role in disease. Curr. Opin. Hematol. 8:28.
4. Wong, C. K., Zhang, J. P., Ip, W. K. and Lam, C. W. K. 2002. Activation of p38 mitogen-activated protein kinase and NF-κB in tumor necrosis factor-α-induced eotaxin release of human eosinophils. Clin. Exp. Immunol. 128:483.
5. Giembycz, M. A. and Lindsay, M. A. 1999. Pharmacology of the eosinophil. Pharmacol. Rev. 51:213.
6. Dent, G., Ruhlmann, E., Bodtke, K., Magnussen, H. and Rabe, K. F. 2000. Up-regulation of human eosinophil leukotriene C4 generation through contact with bronchial epithelial cells. Inflamm. Res. 49:236.
7. Takafuji, S., Ohtoshi, T., Takizawa, H., Tadokoro, K. and Ito, K. 1996. Eosinophil degranulation in the presence of bronchial epithelial cells. Effect of cytokines and role of adhesion. J. Immunol. 156: 3980.
8. Wong, C. K., Wang, C. B., Ip, W. K., Tian, Y. P. and Lam, C. W. K. 2005. Role of p38 MAPK and NF-κB for chemokine release in co-culture of human eosinophils and bronchial epithelial cells. Clin. Exp. Immunol. 139:90.
9. Wang, C. B., Wong, C. K., Ip,W. K., Li, M. L. Y., Tian, Y. P. and Lam, C. W. K. 2005. Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-κB. Allergy 60:1378.
10. Busse, W. W. and Rosenwasser, L. J. 2003. Mechanisms of asthma. J. Allergy Clin. Immunol. 111:S799.
11. Kalsheker, N. A., Deam, S., Chambers, L., Sreedharan, S., Brocklehurst, K. and Lomas, D. A. 1996. The house dust mite allergen Der p1 catalytically inactivates alpha 1-antitrypsin by specific reactive centre loop cleavage: A mechanism that promotes airway inflammation and asthma. Biochem Biophys Res Commun. 221:59.
12. Brown, A., Farmer, K., MacDonald, L. et al. 2003. House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors. Am. J. Respir. Cell Mol. Biol. 29:381.
13. Sharma, S., Lackie, P. M. and Holgate, S. T. 2003. Uneasy breather: The implications of dust mite allergens. Clin. Exp. Allergy 33:163.
14. Schulz, O., Sewell, H. F. and Shakib, F. 1998. Proteolytic cleavage of CD25, the alpha subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J. Exp. Med. 187:271.
15. Ghaemmaghami, A. M. and Shakib, F. 2002. Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells. Clin. Exp. Allergy 32:728.
16. King, C., Brennan, S., Thompson, P. J. and Stewart, G. A. 1998. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J. Immunol. 161:3645.
17. Mori, L., Kleimberg, J., Mancini, C., Bellini, A., Marini, M. and Mattoli, S. 1995. Bronchial epithelial cells of atopic patients with asthma lack the ability to inactivate allergens. Biochem. Biophys. Res. Commun. 217:817.
18. Stacey, M. A., Sun, G., Vassalli, G., Marini, M., Bellini, A. and Mattoli, S. 1997. The allergen Der p1 induces NF-kappaB activation through interference with IkappaB alpha function in asthmatic bronchial epithelial cells. Biochem. Biophys. Res. Commun. 236:522.
19. Adam, E., Hansen, K. K., Astudillo Fernandez, O. et al. 2005. The house dust mite allergen DER P 1, unlike DER P 3, stimulates the expression of IL-8 in human airway epithelial cells via a proteinase-activated receptor-2 (PAR2) independent mechanism. J. Biol. Chem. 281:6910.
20. Coward,W. R., Sagara, H., Wilson, S. J., Holgate, S. T. and Church, M. K. 2004. Allergen activates peripheral blood eosinophil nuclear factor-kappaB to generate granulocyte macrophage-colony stimulating factor, tumour necrosis factor-alpha and interleukin-8. Clin. Exp. Allergy 34:1071.
21. Pichavant, M., Charbonnier, A. S., Taront, S. et al. 2005. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J. Allergy Clin. Immunol. 115:771.
22. Wong, C. K., Lun, S. W. M., Ko, F. W. S., Ip, W. K., Hui, D. S. C. and Lam, C. W. K. 2005. Increased expression of plasma and cell surface costimulatory molecules CTLA-4, CD28 and CD86 in adult patients with allergic asthma. Clin. Exp. Immunol. 141:122.
23. Wong, C. K. and Lam, C. W. K. 2003. Clinical applications of cytokine assays. Adv. Clin. Chem. 37:1.
24. Tarnok, A., Hambsch, J., Chen, R. and Varro, R. 2003. Cytometric bead array to measure six cytokines in twenty-five microliters of serum. Clin. Chem. 49:1000.
25. Contreras, J. P., Ly, N. P., Gold, D. R. et al. 2003. Allergen-induced cytokine production, atopic disease, IgE, and wheeze in children. J. Allergy Clin. Immunol. 112:1072.
26. Que, X., Kim, S. H., Sajid, M. et al. 2003. A surface amebic cysteine proteinase inactivates interleukin-18. Infect. Immun. 71:1274.
27. Akdis, M., Blaser, K. and Akdis, C. A. 2005. T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J. Allergy Clin. Immunol. 116:961.
28. Xystrakis, E., Kusumakar, S., Boswell, S. et al. 2006. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J. Clin. Invest. 116:146.
29. Wong, C. K., Ho, C. Y., Ko, F. W. S. et al. 2001. Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-γ, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol. 125:177.
30. Truyen, E., Coteur, L., Dilissen, E. et al. 2006. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61:202.
31. Bettiol, J., Sele, J., Henket, M. et al. 2002. Cytokine production from sputum cells after allergenic challenge in IgE-mediated asthma. Allergy 57:1145.
32. Greenwel, P., Inagaki, Y., Hu, W., Walsh, M. and Ramirez, F. 1997. Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1. J. Biol. Chem. 272:19738.
33. Pawankar, R. 2002. Epithelial cells as immunoregulators in allergic airway diseases. Curr. Opin. Allergy Clin. Immunol. 2:1.
34. Atsuta, J., Plitt, J., Bochner, B. S. and Schleimer, R. P. 1999. Inhibition of VCAM-1 expression in human bronchial epithelial cells by glucocorticoids. Am. J. Respir. Cell Mol. Biol. 20:643.
35. Xu, X. and Hakansson, L. 2000. Regulation of the release of eosinophil cationic protein by eosinophil adhesion. Clin. Exp. Allergy 30:794.
36. Jia, G. Q., Gonzalo, J. A., Hidalgo, A., Wagner, D., Cybulsky, M. and Gutierrez-Ramos, J. C. 1999. Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/ VCAM-1 interactions. Int. Immunol. 11:1.
37. Sedgwick, J. B., Menon, I., Gern, J. E. and Busse, W. W. 2002. Effects of inflammatory cytokines on the permeability of human lung microvascular endothelial cell monolayers and differential eosinophil transmigration. J. Allergy Clin. Immunol. 110:752.
38. Fernvik, E., Lundahl, J. and Hallden, G. 2000. The impact of eotaxin- and IL-5-induced adhesion and transmigration on eosinophil activity markers. Inflammation 24:73.
39. Wong, C. K., Ip, W. K. and Lam, C. W. K. 2003. IL-3, 5 and GM-CSF-induced adhesion molecule expression on eosinophils by p38 MAPK and NF-κB. Am. J. Respir. Cell Mol. Biol. 29:133.
40. Mastrandrea, F., Nicotra, M. R., De Vita, L. et al. 2003. Mite antigens enhance ICAM-1 and induce VCAM-1 expression on human umbilical vein endothelium. Allergol. Immunopathol. (Madr.). 31:259.
41. Burke-Gaffney, A. and Hellewell, P. G. 1998. A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 19:408.
42. Horie, S. and Kita, H. 1994. CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor. J. Immunol. 152:5457.
43. Rothenberg, M. E., Zimmermann, N., Mishra, A. et al. 1999. Chemokines and chemokine receptors: Their role in allergic airway disease. J. Clin. Immunol. 19:250.
44. Newton, R. and Holden, N. 2003. Inhibitors of p38 mitogen-activated protein kinase: Potential as anti-inflammatory agents in asthma? BioDrugs 17:113.
45. Makarov, S. S. 2000. NF-kappaB as a therapeutic target in chronic inflammation: Recent advances. Mol. Med. Today 6:441.