Involvement of globus pallidus in the antiparkinsonian effects of adenosine A2A receptor antagonists

Experimental Neurology

Volumn 202, Issue 1, 2006, Pages 255-257

  Simola, Nicola ^a   Fenu, Sandro ^a   Baraldi, Pier G ^c   Tabrizi, Mojgan Aghazadeh ^c   Morelli, Micaela ^a,b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

6 Hydroxydopamine; A2A antagonists; Globus pallidus; Parkinson's disease; Rotational behavior

Indexed keywords

ADENOSINE A2A RECEPTOR ANTAGONIST; ANTIPARKINSON AGENT; BENSERAZIDE; LEVODOPA; OXIDOPAMINE; SCH BT2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY EQUILIBRIUM; CIRCLING BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; GLOBUS PALLIDUS; LOCOMOTION; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; ANTIPARKINSON AGENTS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; FUNCTIONAL LATERALITY; GLOBUS PALLIDUS; LEVODOPA; MALE; OXIDOPAMINE; PARKINSONIAN DISORDERS; PIPERAZINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; TIME FACTORS;

EID: 33748435761     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.05.015     Document Type: Article

References (18)

1. Baraldi P.G., Cacciari B., Romagnoli R., Spalluto G., Monopoli A., Ongini E., and Borea K. 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility. J. Med. Chem. 45 (2002) 115-126
2. Bibbiani F., Oh J.D., Petzer J.P., Castagnoli Jr. N., Chen J.F., Schwarzschild M.A., and Chase T.N. A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease. Exp. Neurol. 184 (2003) 285-294
3. Dauer W., and Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39 (2003) 889-909
4. Fenu S., Pinna A., Ongini E., and Morelli M. Adenosine A2A receptor antagonism potentiates l-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats. Eur. J. Pharmacol. 321 (1997) 143-147
5. Ferré S., O'Connor W.T., Fuxe K., and Ungerstedt U. The striopallidal neuron: a main locus for adenosine-dopamine interactions in the brain. J. Neurosci. 13 (1993) 5402-5406
6. Ferré S., Fredholm B.B., Morelli M., Popoli P., and Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20 (1997) 482-487
7. Hillion J., Canals M., Torvinen M., Casado V., Scott R., Terasmaa A., Hansson A., Watson S., Olah M.E., Mallol J., Canela E.I., Zoli M., Agnati L.F., Ibanez C.F., Lluis C., Franco R., Ferré S., and Fuxe K. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J. Biol. Chem. 277 (2002) 18091-18097
8. Koga K., Kurokawa M., Ochi M., Nakamura J., and Kuwana Y. Adenosine A(2A) receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats. Eur. J. Pharmacol. 408 (2000) 249-255
9. Morelli M. Adenosine A2A antagonists: potential preventive and palliative treatment for Parkinson's disease. Exp. Neurol. 184 (2003) 20-23
10. Mori A., and Shindou T. Modulation of GABAergic transmission in the striatopallidal system by adenosine A2A receptors: a potential mechanism for the antiparkinsonian effects of A2A antagonists. Neurology 61 11 Suppl. 6 (2003) S44-S48
11. Ochi M., Koga K., Kurokawa M., Kase H., Nakamura J., and Kuwana Y. Systemic administration of adenosine A(2A) receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study. Neuroscience 100 (2000) 53-62
12. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates (1998), Academic Press, Sydney
13. Pinna A., Di Chiara G., Wardas J., and Morelli M. Blockade of A2a adenosine receptors positively modulates turning behaviour and c-Fos expression induced by D1 agonists in dopamine-denervated rats. Eur. J. Neurosci. 8 (1996) 1176-1181
14. 2A receptors in the rat central nervous system. J. Comp. Neurol. 401 (1998) 163-186
15. Schiffmann S.N., and Vanderhaeghen J.J. Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J. Neurosci. 13 (1993) 1080-1087
16. Shindou T., Mori A., Kase H., and Ichimura M. Adenosine A(2A) receptor enhances GABA(A)-mediated IPSCs in the rat globus pallidus. J. Physiol. 532 Pt 2 (2001) 423-434
17. Simola N., Fenu S., Baraldi P.G., Tabrizi M.A., and Morelli M. Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions. Exp. Neurol. 189 (2004) 182-188
18. Xu K., Bastia E., and Schwarzschild M.A. Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease. Pharmacol. Ther. 105 (2005) 267-310