Early and late molecular events of glucose-induced pexophagy in Pichia pastoris require Vac8

Autophagy

Volumn 2, Issue 4, 2006, Pages 280-288

  Fry, Michelle R ^b   Thomson, J Michael ^a   Tomasini, Amber J ^a   Dunn, William A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b BRADLEY UNIVERSITY   (United States)

Author keywords

Armadillo Repeat; Autophagy; Myristoylation; Palmitoylation; Peroxisome; Vacuole

Indexed keywords

ALCOHOL OXIDASE; FUNGAL PROTEIN; PROTEIN VAC8; UNCLASSIFIED DRUG;

ARMADILLO; ARTICLE; AUTOPHAGY; CELL VACUOLE; ENZYME ACTIVITY; MUTAGENESIS; MYRISTYLATION; NONHUMAN; PICHIA PASTORIS; STARVATION; TONOPLAST;

ARMADILLO; PICHIA PASTORIS;

EID: 33748433784     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.3164     Document Type: Article

References (40)

1. Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
2. Meijer AJ, Codogno P. Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol 2004; 36:2443-62.
3. Codogno P, Meijer AJ. Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 2005; 12(Suppl 2):1509-18.
4. Dunn Jr WA. Pathways in mammalian protein degradation. In: Makrides SC, ed. Gene transfer and expression in mammalian cells. Amsterdam: Elsevier Science, 2003:513-33.
5. Tuttle DL, Dunn Jr WA. Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris. J Cell Sci 1995; 108:25-35.
6. Yuan W, Stromhaug PE, Dunn Jr WA. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. Mol Biol Cell 1999; 10:1353-66.
7. Stromhaug PE, Bevan A, Dunn Jr WA. GSA11 encodes a unique 208-kDa protein required for pexophagy and autophagy in Pichia pastoris. J Biol Chem 2001; 276:42422-35.
8. Chang T, Schroder LA, Thomson JM, Klocman AS, Tomasini AJ, Stromhaug PE, Dunn Jr WA. PpATG9 encodes a novel membrane protein that traffics to vacuolar membranes, which sequester peroxisomes during pexophagy in Pichia pastoris. Mol Biol Cell 2005; 16:4941-53.
9. Sakai Y, Koller A, Rangell LK, Keller GA, Subramani S. Peroxisome degradation by microautophagy in Pichia pastoris. Identification of specific steps and morphological intermediates. J Cell Biol 1998; 141:625-36.
10. Mukaiyama H, Oku M, Baba M, Samizo T, Hammond AT, Glick BS, Kato N, Sakai Y. Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy. Genes to Cells 2002; 7:75-90.
11. Mukaiyama H, Baba M, Osumi M, Aoyagi S, Kato N, Ohsumi Y, Sakai Y. Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structure. Mol Biol Cell 2004; 15:58-70.
12. Dunn Jr WA, Cregg JM, Kiel JAKW, van der Klei IJ, Oku M, Sakai Y, Stasyk OV, Veenhuis M. Pexophagy: The selective autophagy of peroxisomes. Autophagy 2005; 1:75-83.
13. Klionsky DJ, Cregg JM, Dunn Jr WA, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539-45.
14. Kim J, Kanada Y, Stromhaug PE, Guan J, Hefner-Gravink A, Baba M, Scott SV, Ohsumi Y, Dunn WA, Klionsky DJ. Cvt9/gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol 2001; 153:381-96.
15. Guan J, Stromhaug PE, George MD, Habibzadegah-Tari P, Bevan A, Dunn Jr WA, Klionsky DJ. Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris. Mol Biol Cell 2001; 12:3821-38.
16. Wang YX Zhao H, Harding TM, Gomes de Mesquita DS, Woldringh CL, Klionsky DJ, Munn AL, Weisman LS. Multiple classes of yeast mutants are detective in vacuole partitioning yet target vacuole proteins correctly. Mol Biol Cell 1996; 7:1375-89.
17. Khalfan WA, Klionsky DJ. Molecular machinery required for autophagy and the cytoplasm to vacuole targeting (Cvt) pathway in S. cerevisiae. Curr Opin Cell Biol 2002; 14:468-75.
18. Wang YX, Catlett NL, Weisman LS. Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol 1998; 140:1063-74.
19. Scott SV, Nice IIIrd DC, Nau JJ, Weisman LS, Kamada Y, Keizer-Gunnink I, Funakoshi T, Veenhuis M, Ohsumi Y, Klionsky DJ. Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem 2000; 275:25840-9.
20. Roberts P, Moshitch-Moshkovitz S, Kvam E, O'Toole E, Winey M, Goldferb DS. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol Biol Cell 2003; 14:129-41.
21. Pan X, Goldfarb DS. YEB3/VAC8 encodes a myristylated armadillo protein of the Saccharomyces cerevisiae vacuolar membrane that functions in vacuole fusion and inheritance. J Cell Sci 1998; 111:2137-47.
22. Pan X, Roberts P, Chen Y, Kvam E, Shulga N, Huang K, Lemmon S, Goldfarb DS. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell 2000; 11:2445-57.
23. Weisman LS, Wickner W. Intervacuole exchange in the yeast zygote: A new pathway in organelle communication. Science 1988; 241:589-91.
24. Wang YX, Kauffman EJ, Duex JE, Weisman LS. Fusion of docked membranes requires the armadillo repeat protein Vac8p. J Biol Chem 2001; 276:35133-40.
25. Veit M, Laage R, Dietrich L, Wang L, Ungermann C. Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion. Embo J 2001; 20:3145-55.
26. Dietrich LE, Gurezka R, Veit M, Ungermann C. The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion. Embo J 2004; 23:45-53.
27. Sears IB, O'Connor J, Rossanese OW, Glick BS. A versatile set of vectors of constitutive and regulated gene expression in Pichia pastoris. Yeast 1998; 14:783-90.
28. Veenhuis M, Douma A, Harder W, Osumi M. Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes. Arch Microbiol 1983; 134:193-203.
29. Ano Y, Hattori T, Oku M, Mukaiyama H, Baba M, Ohsumi Y, Kato N, Sakai Y. A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate. Mol Biol Cell 2005; 16:446-57.
30. Oku M, Warnecke D, Noda T, Muller F, Heinz E, Mukaiyama H, Kato N, Sakai Y. Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain. Embo J 2003; 22:3231-41.
31. Fleckenstein D, Rohde M, Klionsky DJ, Rudiger M. Yc1013p (Vac8p), an armadillo repeat protein related to plakoglobin and importin alpha is associated with the yeast vacuole membrane. J Cell Sci 1998; 111:3109-18.
32. Wang CW, Klionsky DJ. The molecular mechanism of autophagy. Mol Med 2003; 9:65-76.
33. Reggiori F, Tucker KA, Stromhaug PE, Klionsky DJ. The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the preautophagosomal structure. Dev Cell 2004; 6:79-90.
34. Shimani T, Klionsky DJ. Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway. J Biol Chem 2004; 279:29889-94.
35. Oku M, Nishimura T, Hattori T, Ano Y, Yamashita S, Sakai Y. Role of Vac8 in formation of the vacuolar sequestering membrane during micropexophagy. Autophagy 2006; 2:272-9.
36. Subramanian K, Dietrich LE, Hou H, Lagrassa TJ, Meiringer CT, Ungermann C. Palmitoylation determines the function of Vac8 at the yeast vacuole. J Cell Sci 2006; 119:2477-85.
37. Coates JC. Armadillo repeat proteins: Beyond the animal kingdom. Trends Cell Biol 2003; 13:463-71.
38. Wang CW, Stromhaug PE, Kauffman EJ, Weisman LS, Klionsky DJ. Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J Cell Biol 2003; 163:973-85.
39. Cregg JM, Barringer KJ, Hessler AY, Madden KR. Pichia pastoris as a host system for transformations. Mol Cell Biol 1985; 5:3376-85.
40. Yuan W, Tuttle DL, Shi YJ, Ralph GS, Dunn Jr WA. Glucose-induced microautophagy in Pichia pastoris requires the alpha-subunit of phosphofructokinase. J Cell Sci 1997; 110:1935-45.